A5053557431- Polymer Surface Interaction Studies
- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
- Advanced Sensor and Energy Harvesting Materials
- Coronary Interventions and Diagnostics
- Polymer composites and self-healing
- Antimicrobial agents and applications
- Analytical Chemistry and Chromatography
- Nanocomposite Films for Food Packaging
- Surface Modification and Superhydrophobicity
- Nanoplatforms for cancer theranostics
- Analytical chemistry methods development
- Graphene and Nanomaterials Applications
- Magnesium Alloys: Properties and Applications
- Angiogenesis and VEGF in Cancer
- Luminescence and Fluorescent Materials
- Corrosion Behavior and Inhibition
- Nanoparticles: synthesis and applications
- Lignin and Wood Chemistry
- Orthopaedic implants and arthroplasty
- Conducting polymers and applications
- Silk-based biomaterials and applications
- Advanced Nanomaterials in Catalysis
- Protease and Inhibitor Mechanisms
- Antimicrobial Peptides and Activities
Jiangnan University
2003-2025
Anhui Medical University
2021-2025
Northwestern Polytechnical University
2024
Southwest Jiaotong University
2014-2022
Chengdu University
2016-2018
National Engineering Research Center of Electromagnetic Radiation Control Materials
2018
University of Electronic Science and Technology of China
2018
University of Jinan
2011
As a typical bioflavonoid, diosmetin is desirable in the field of natural medicine, healthy food, and cosmetics by anti-cancer, antibacterial, antioxidant, estrogen-like anti-inflammatory activities, it comes from wide range sources traditional Chinese medicine like spider fragrance, spearmint chrysanthemum, as well Citrus fruit. However, analytical methods such silica gel column chromatography face multiple challenges selective extraction biological materials medicinal materials. Therefore,...
Stenting is currently the major therapeutic treatment for cardiovascular diseases. However, nonbiogenic metal stents are inclined to trigger a cascade of cellular and molecular events including inflammatory response, thrombogenic reactions, smooth muscle cell hyperproliferation accompanied by delayed arterial healing, poor reendothelialization, thus leading restenosis along with late stent thrombosis. To address prevalence critical problems, we present an endothelium-mimicking coating...
Abstract Vascular stent is viewed as one of the greatest advancements in interventional cardiology. However, current approved stents suffer from in-stent restenosis associated with neointimal hyperplasia or thrombosis. Herein, we develop a nitric oxide-eluting (NOE) hydrogel coating for vascular inspired by biological functions oxide cardiovascular system. Our NOE mechanically tough and could selectively facilitate adhesion endothelial cells. Besides, it non-thrombotic capable inhibiting...
Abstract Endothelium can secrete vasoactive mediators and produce specific extracellular matrix, which contribute jointly to the thromboresistance regulation of vascular cell behaviors. From a bionic point view, introducing endothelium‐like functions onto cardiovascular stents represents most effective means improve hemocompatibility reduce late stent restenosis. However, current surface strategies for still have limitations, like lack multifunctionality, especially monotony in...
Thrombosis and infections are the two major complications associated with extracorporeal circuits indwelling medical devices, leading to significant mortality in clinic. To address this issue, here, we report a biomimetic surface engineering strategy by integration of mussel-inspired adhesive peptide, bio-orthogonal click chemistry, tailor functionalities tubing catheters. Inspired mussel foot protein, bioclickable peptide mimic (DOPA)4-azide-based structure is designed grafted on an...
With the fast development of new science and technology, wearable devices are in great demand modern human daily life. However, energy problem is a long-lasting issue to achieve real smart, wearable, portable devices. Flexible thermoelectric generators (TEGs) based on conversion systems can convert body waste heat into electricity with excellent flexibility wearability, which shows direction solving this issue. Here work, polyethylenimine (PEI) gold nanoparticles (Au NPs) twin...
A novel and facile metal–phenolic–amine surface modification strategy is presented to engineer a multifunctional coating on blood-contacting devices, which combats thrombosis infection simultaneously.
Abstract The unique advantages of nitric oxide (NO) in cardiovascular disease therapy have driven the development methods to functionalize stents for local generation NO. However, current NO-generating materials used surface engineering limitations such as a complex fabrication process, poor stent adhesion strength, and low control NO release. Herein, we apply synergetic coordination catecholamine chemistry develop an adhesive coating with copper-catecholamine framework through simple,...
A novel color-changing and self-healing hybrid hydrogel was prepared by mixing the thermochromic dye microcapsules photochromic with multi-branched polyacrylate.
Flexible electronics have aroused great interest over the past few years due to their unique advantages of being wearable and lightweight. Introducing self-healing function into will contribute practical applications by prolonging devices' lifetime. In this study, a flexible essential oil (EO)-loaded mesoporous silica (EO@AMS)/polyacrylate hybrid hydrogel with superb antibacterial properties was prepared. The prepared found excellent piezoresistive sensing performance, which could be...
Sustained and controllable release characteristics are pivotal factors for novel drug delivery technologies. TiO2 nanotube arrays prepared by self-ordering electrochemical anodization attractive the development of biomedical devices local applications. In this work, several layers polydopamine (PDA) were deposited to functionalize arrays. The anticoagulant bivalirudin (BVLD) was used as a model drug. PDA extended period BVLD maintained sustained kinetic. Depending on number layers, improved,...
Integration of two or more biomolecules with synergetic and complementary effects on a material surface can help to obtain multi-functions for various biomedical applications. However, the amounts integrated their physiological functions are compromised due limited anchoring sites. Herein, we propose novel concept film engineering strategy "from bulk modification". This new is realized by employing amine groups plasma polymerized allylamine (PPAm) grafting molecule e.g., thrombin inhibitor,...
Abstract Thrombosis and infections are the main causes of implant failures (e.g., extracorporeal circuits indwelling medical devices), which induce significant morbidity mortality. In this work, an endothelium‐mimicking surface is engineered, combines nitric oxide (NO)‐generating property anti‐fouling function a healthy endothelium. The released gas signal molecules NO glycocalyx matrix macromolecules hyaluronic acid (HA) jointly combine long‐ short‐distance defense actions against...
Application of extracorporeal circuits and indwelling medical devices has saved many lives. However, it is accompanied with two major complications: thrombosis infection. To address this issue, we apply therapeutic nitric oxide gas (NO) antibacterial peptide for synergistically tailoring such surface anti-thrombogenic antifouling dual functions. Such functional realized by stepwise conjugation NO-generating compound 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) chelated...
Endovascular stenting is a safer alternative to open surgery for use in treating cerebral arterial stenosis and significantly reduces the recurrence of ischemic stroke, but widely used bare-metal stents (BMSs) often result in-stent restenosis (ISR). Although evidence suggests that drug-eluting are superior BMSs short term, their long-term performances remain unknown. Herein, we propose potential vascular stent modified by immobilizing clickable chemerin 15 (C15) peptides on surface suppress...