A5084061311- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Genetics and Neurodevelopmental Disorders
- Inflammasome and immune disorders
- Mitochondrial Function and Pathology
- Antiplatelet Therapy and Cardiovascular Diseases
University of South China
2022-2025
First Affiliated Hospital of University of South China
2024-2025
Importance It is uncertain whether intravenous methylprednisolone improves outcomes for patients with acute ischemic stroke due to large-vessel occlusion (LVO) undergoing endovascular thrombectomy. Objective To assess the efficacy and adverse events of adjunctive low-dose thrombectomy secondary LVO. Design, Setting, Participants This investigator-initiated, randomized, double-blind, placebo-controlled trial was implemented at 82 hospitals in China, enrolling 1680 proximal intracranial LVO...
Introduction： The role of endovascular thrombectomy (EVT) for acute extra-large ischemic stroke patients with large vessel occlusion (LVO) is uncertain. We aimed to explore the clinical and safety outcomes medical management (MM) plus EVT (EVT group) versus MM alone (MM among LVO within 24 hours last known well. Methods： XL STROKE (endovascular stroke) an investigator-initiated, nationwide, prospective registry blinded end point assessment performed at approximately 60 sites in China, will...
Background: Cerebral ischemia-reperfusion injury (CIRI) exacerbates neuronal damage through mechanisms including apoptosis and autophagy dysregulation. Resveratrol (Res), a natural polyphenol with neuroprotective properties, may alleviate CIRI-induced by modulating key signaling pathways. This study investigates the therapeutic effects of Res on CIRI, focusing its role in balancing via regulation nuclear receptor subfamily 3 group C member 2 (NR3C2) tripartite motif containing 28 (TRIM28)....
Background First‐pass successful reperfusion (FPSR), defined as a successful/complete achieved after single thrombectomy pass, is predictive of favorable outcome in patients with acute ischemic stroke large‐vessel occlusion. It unknown whether intravenous tirofiban effective increasing the rate FPSR anterior occlusion stroke. Methods and Results Patients who had presenting within 24 hours underwent endovascular were analyzed from RESCUE BT (Intravenous Tirofiban for With Large Vessel...
HECTD3 (HECT domain E3 ubiquitin protein ligase 3) exerts biological activities in neuroinflammation of distinct diseases, such as autoimmune encephalomyelitis and donations after heart death. However, the effect on diabetes-associated cognitive decline (DACD) remains unclear.
Abstract Background Two trials in Chinese population showed that endovascular treatment (EVT) alone was noninferior to alteplase follow by EVT at 90 days. However, results of long-term clinical outcomes remain unknown. We reported the prespecified 18-month analysis DEVT trail. Materials and methods assessed 18 months after patients were randomly assigned receive or bridging therapy for acute ischemic stroke (AIS). The primary outcome proportion functional independence [modified Rankin scale...