A5101510400- Gut microbiota and health
- Metabolomics and Mass Spectrometry Studies
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Advanced biosensing and bioanalysis techniques
- Probiotics and Fermented Foods
- Inflammatory Bowel Disease
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Prostate Cancer Treatment and Research
- Neurogenesis and neuroplasticity mechanisms
- Epigenetics and DNA Methylation
- Advanced Nanomaterials in Catalysis
- Traditional Chinese Medicine Studies
- Glioma Diagnosis and Treatment
- Inflammasome and immune disorders
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Barrier Structure and Function Studies
- Nanoplatforms for cancer theranostics
- Autophagy in Disease and Therapy
- Advanced MRI Techniques and Applications
- Diet and metabolism studies
- Ultrasound and Hyperthermia Applications
- Microbial Metabolism and Applications
State Key Laboratory of Food Science and Technology
2024-2025
Jiangnan University
2020-2025
First Affiliated Hospital of Zhengzhou University
2022-2024
North University of China
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Jiangxi University of Traditional Chinese Medicine
2022-2024
Guangdong Medical College
2024
Guangzhou University of Chinese Medicine
2021-2022
Second Military Medical University
2018-2022
Xiamen University
2020-2022
<italic>Lactobacillus acidophilus</italic> alleviates type 2 diabetes induced by a high fat diet and streptozotocin (STZ) injection regulating gut microbiota, hepatic glucose lipid metabolism in mice.
The intricate relationship between resistant starch (RS) and the gut microbiome presents a dynamic frontier in nutrition science. This review synthesizes current understandings of how RS, an indigestible form found naturally certain foods also enhanced through various modification methods, interacts with microbiome. We particularly focus on RS fermentation colon contributes to production beneficial volatile fatty acids (VFAs) such as butyrate, acetate, propionate. These VFAs have been...
Chemotherapy is commonly used for the treatment of lung cancer, but strong side effects and low efficacy limit its clinical application. Here, extracellular vesicles (EVs) as natural drug delivery carriers were to load conventional anticancer doxorubicin (DOX) a chemosensitizer lonidamine (LND). Two types EVs with different sizes (16k 120k EVs) prepared using centrifugation forces. We found that co-delivery DOX LND both enhanced cytotoxicity reduced dose significantly in vitro. Effective...
Purpose: Cancer stem-like cells (CSC) contribute to the progression and androgen deprivation therapy (ADT) resistance of prostate cancer. As CSCs depend on their specific niche, including tumor-associated macrophages (TAM), elucidating network between TAMs may help effectively inhibit ADT cancer.Experimental Design: The underlying intracellular mechanism that sustains characteristics in cancer was assessed via RNA sequencing, co-immunoprecipitation, chromatin immunoprecipitation, other...
<italic>L. plantarum</italic> KLDS 1.0386 combined with tryptophan alleviates ulcerative colitis (UC) induced by dextran sodium sulfate (DSS) increasing the level of indole-3-acetic acid (IAA), stimulating AHR/IL-22/STAT3 signaling pathway and regulating gut microbiota in mice.
Ulcerative colitis (UC) is a major disease that has endangered human health. Our previous study demonstrated Bifidobacterium longum subsp. YS108R, ropy exopolysaccharide (EPS)-producing bacterium, could alleviate UC in mice, but it unclear whether EPS the key substance responsible for its action. In this study, we proposed to investigate remitting effect of from B. YS108R on DSS-induced mouse model. Water extraction and alcohol precipitation were applied extract supernatant culture. Then...
The prebiotic properties of human milk oligosaccharides (HMOs) and emerging evidence immunomodulatory effects suggest their potential therapeutic value in allergy management. 2'-Fucosyllactose (2'-FL) has been reported to alleviate food allergies, while the effect other fucosylated HMOs on remains unclear. In this study, we assess two HMOs, 2'-FL 3-fucosyllactose (3-FL), symptomatology immunological responses an ovalbumin (OVA)-sensitized mouse model as well influence gut microbiota....
Cognitive deficiency is one of the fundamental characteristics late-onset depression (LOD). Luteolin (LUT) possesses antidepressant, anti-aging, and neuroprotective properties, which can dramatically enhance cognition. The altered composition cerebrospinal fluid (CSF), involved in neuronal plasticity neurogenesis, directly reflects physio-pathological status central nervous system. It not well known whether effect LUT on LOD association with a changed CSF composition. Therefore, this study...
In most bladder cancer (BC) patients, cells will eventually develop chemical resistance causing increased mortality. This study aimed to explore the mechanism of lncRNA plasmacytoma variant translocation 1 (PVT1) in regulating doxorubicin (ADM) BC cells. We observed that PVT1 expression was upregulated ADM-resistant compared with ADM-sensitive Downregulation suppressed cell proliferation and invasion, promoted apoptosis, sensitivity ADM, while overexpression growth their ADM. Further...
Folates, provided by food, are commonly used antidepressant synergists in late-onset depression (LOD). However, increased intake of folic acid the elderly population might lead to accumulation unmetabolized systemic circulation, leading enhanced deterioration central nervous system function. In addition, folates cannot access brain directly because blood-brain barrier. Choroid plexus (CP) 5-methyltetrahydrofolate (5-MTHF) transport plays a critical role regulating cerebrospinal fluid (CSF)...
Non-small cell lung cancer (NSCLC) is the most common type of with substantial morbidity and mortality. Herein, a new signal-on electrochemiluminescence (ECL) immunosensor based on multiple amplification strategies constructed for ultrasensitive detection cytokeratin 19 fragment antigen 21-1 (CYFRA21-1) biomarker related to NSCLC. Polyethyleneimine (PEI) functionalized MXene decorated NiMn layer double hydroxide (NiMn LDH) form MXene-PEI-NiMn LDH composite. Specially, La-MOF@ZIF-67...
To observe the curative effect of Weiansan (WAS) on gastric precancerous lesions (GPL) and H pylori elimination.
Lung cancer remains the leading killer around world. It's crucial to identify newer mechanism-based targets effectively manage lung cancer. Annexin A5 (ANXA5) is a protein kinase C inhibitory and calcium dependent phospholipid-binding protein, which may act as an endogenous regulator of various pathophysiological processes. However, its molecular mechanism in poorly understood. This study was designed determine ANXA5 with hope obtain useful information provide new therapeutic target. We used...