A5008801769- Migraine and Headache Studies
- Tryptophan and brain disorders
- Iron and Steelmaking Processes
- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Sleep and Wakefulness Research
- Stress Responses and Cortisol
- Phytochemistry and Bioactive Compounds
- Metallurgical Processes and Thermodynamics
- Phytochemical Studies and Bioactivities
- Drilling and Well Engineering
- CO2 Sequestration and Geologic Interactions
- Geothermal Energy Systems and Applications
- Marine Sponges and Natural Products
- Genetic Associations and Epidemiology
- Advanced Nanomaterials in Catalysis
- Innovations in Concrete and Construction Materials
- Neuroscience of respiration and sleep
- TiO2 Photocatalysis and Solar Cells
- Liver Disease Diagnosis and Treatment
- Synthetic Organic Chemistry Methods
- Advanced Photocatalysis Techniques
- Gut microbiota and health
- Sleep and Work-Related Fatigue
- Hydraulic Fracturing and Reservoir Analysis
Chinese PLA General Hospital
2020-2025
Harbin Engineering University
2024
Guangzhou University of Chinese Medicine
2022-2024
Yangtze University
2023-2024
Chinese Institute for Brain Research
2023
Peking University
2023
Jinzhou Medical University
2020-2023
Guilin University of Technology
2023
Southwest Jiaotong University
2022
Jinzhou Central Hospital
2020
Recently, visible light-driven organic photochemical synthesis has been a pioneering field of interest from academic and industrial associations due to its unique features green sustainable chemistry. Herein, WO3ZnO/Fe3O4 was synthesized, characterized, used as an efficient magnetic photocatalyst in the preparation range 2-substituted benzimidazoles via condensation benzyl alcohol o-phenylenediamine ethanol at room temperature for first time. The key feature this work is focused on situ...
Quercetin, an abundant flavonoid compound in plants, is considered a novel antidepressant; however, its mechanisms of action are poorly understood. This study aimed to investigate the therapeutic effects quercetin on chronic unpredictable mild stress (CUMS)-induced depression-like behaviors rats and explore underlying by combining untargeted metabolomics 16S rRNA sequencing analysis brain tissue metabolites gut microbiota. Gut microbiota revealed that at phylum level, reduced Firmicutes...
Abstract Background Migraine is a highly disabling health burden with multiple symptoms; however, it remains undertreated because of an inadequate understanding its neural mechanisms. Neuropeptide Y (NPY) has been demonstrated to be involved in the modulation pain and emotion, may play role migraine pathophysiology. Changes NPY levels have found patients migraine, but whether how these changes contribute unknown. Therefore, purpose this study was investigate migraine-like phenotypes. Methods...
Cognitive deficiency is one of the fundamental characteristics late-onset depression (LOD). Luteolin (LUT) possesses antidepressant, anti-aging, and neuroprotective properties, which can dramatically enhance cognition. The altered composition cerebrospinal fluid (CSF), involved in neuronal plasticity neurogenesis, directly reflects physio-pathological status central nervous system. It not well known whether effect LUT on LOD association with a changed CSF composition. Therefore, this study...
Whether the positive associations of blood lipids with psychiatric disorders are causal is uncertain. We conducted this two-sample Mendelian randomization (MR) analysis to comprehensively investigate disorders.Univariable and multivariable models were established for MR analyses. Inverse variance-weighted (IVW) was employed as main approach; weighted median MR-Egger used sensitivity methods. The possibility violating assumptions evaluated utilizing several analyses, including heterogeneity...
Migraine is the second disabling neurological disorder with a high prevalence. Aura occurs in one-third of migraineurs and visual aura accounts for over 90%. Cortical spreading depression (CSD) underlies might trigger migraine headaches. Compared CSD induction by invasive electrical, chemical, or mechanical stimulation, optogenetics avoids direct influences on meninges stimulation process. However, previous optogenetic models mainly use Thy1-ChR2-YFP CaMKIIα-cre transgenic mice. They are...
Summary Background The outbreak of coronavirus disease 2019 in China remains to be a serious challenge for frontline medical workers (fMW). They are under high risk being infected and mental stress, which may lead sleep disturbances, anxiety, depression. Methods We conducted cross-sectional study evaluate disturbances fMW made comparison with non-fMW. from multiple hospitals Hubei Province, China, were volunteered participate. An online questionnaire, including Pittsburgh Sleep Quality Index...
Acute sleep deprivation (SD) seriously affects cognitive functions, such as attention, memory, and response inhibition. Previous neuroimaging studies have demonstrated a close relationship between the functional activities of precuneus (PC) function alert attention. However, specific effect PC on attention decline after acute SD has not been elucidated. In this study, we used resting-state magnetic resonance imaging (fMRI) to study changes connectivity alertness total SD.Thirty healthy,...
Migraine, a complex brain disorder, is regarded as possible clinical manifestation of energy dysfunction. The trigeminovascular system considered the basis for pathogenesis migraine, hence we depicted proteomics profiling key regions in this system, then focusing on protein alterations related to mitochondrial function. aim study illustrate role mitochondria migraine.A mouse model chronic migraine (CM) was established by repeated nitroglycerin (NTG) stimulation and evaluated von-Frey...
Gut microbial dysbiosis and gut-brain axis dysfunction have been implicated in the pathophysiology of migraine. However, it is unclear whether migraine-related cephalic allodynia could induce alteration gut composition.A classic migraine rat model was established by repeated dural infusions inflammatory soup (IS). Periorbital mechanical threshold nociception-related behaviors were used to evaluate IS-induced preventive effect topiramate. The alterations composition potential metabolic...
Abstract Background Both epidemiological and clinical studies have indicated that headache sleep disturbances share a complex relationship. Although common neurophysiological anatomical foundations, the mechanism underlying their interaction remains poorly understood. The structures of diencephalon brainstem, particularly locus coeruleus (LC), are primary sites where pathways intersect. To better understand intricate nature relationship between sleep, our study focused on investigating role...
Dopamine (DA) plays multiple roles in a wide range of physiological and pathological processes via vast network dopaminergic projections. To fully dissect the spatiotemporal dynamics DA release both dense sparsely innervated brain regions, we developed series green red fluorescent GPCR activation-based (GRAB
Abstract The excitatory‐inhibitory imbalance has been considered an important mechanism underlying stress‐related psychiatric disorders. In the present study, rats were exposed to 6 days of inescapable foot shock (IFS) induce stress. open field test and elevated plus maze showed that IFS‐exposed exhibited increased anxiety‐like behavior. Immunofluorescence IFS had a decreased density GAD67‐immunoreactive interneurons in dorsal hippocampal CA1 region, while no significant change...
Abstract Porous geopolymer composite (E51) reinforced by E51 epoxy resin was prepared well‐distributed dual‐blending using red mud, metakaolin, and slag as raw materials. The effects of content on microstructure, porosity, mechanical properties, thermal insulation properties the porous composites were investigated. addition changed setting time viscosity slurry with high solid wastes (80%), which play an important role in formation pores during direct foaming process. had great influence...
Based on the research of steel reinforced concrete (SRC) deep beam test and modified strut-and-tie model (STM), a for SRC beams was established shear capacity design formula based deduced, which considers favorable influences tie bar, taking depth compression zone as top nodes reasonably simplifying flange web. By comparing results calculation in this paper with models ACI Chinese code, following conclusions can be drawn:1) force-transferring mechanism failure mode reflected effectively,...