A5065526469- Gastrointestinal motility and disorders
- Recycled Aggregate Concrete Performance
- Genetic Neurodegenerative Diseases
- Innovative concrete reinforcement materials
- Wheat and Barley Genetics and Pathology
- Mitochondrial Function and Pathology
- Neurological disorders and treatments
- Innovations in Concrete and Construction Materials
- Ion channel regulation and function
- Helicobacter pylori-related gastroenterology studies
- Neuroscience and Neuropharmacology Research
- Plant Stress Responses and Tolerance
- Celiac Disease Research and Management
- Concrete and Cement Materials Research
- RNA Interference and Gene Delivery
- Aquaculture disease management and microbiota
- Advanced biosensing and bioanalysis techniques
- Biochemical Analysis and Sensing Techniques
- Genetic factors in colorectal cancer
- Nicotinic Acetylcholine Receptors Study
- Diabetes Treatment and Management
- Phytase and its Applications
- Gastroesophageal reflux and treatments
- Urinary Bladder and Prostate Research
- Plant nutrient uptake and metabolism
Changzhou Institute of Technology
2023-2025
Second Hospital of Liaohe Oilfield
2015-2024
University of Electronic Science and Technology of China
2021-2024
Xi'an University of Architecture and Technology
2021-2023
University College London
2022
Affiliated Hospital of Southwest Medical University
2022
GI Care for Kids
2021
Children's Center
2021
Shanghai Institute of Ceramics
2020-2021
Chinese Academy of Sciences
2020-2021
Huntington's disease (HD) is a dominant neurodegenerative disorder caused by expansion of CAG repeat in the gene encoding huntingtin, protein unknown function. To distinguish between "loss function" and "gain models HD, murine HD homolog Hdh was inactivated targeting. Mice heterozygous for inactivation were phenotypically normal, whereas homozygosity resulted embryonic death. Homozygotes displayed abnormal gastrulation at day 7.5 resorbing 8.5. Thus, huntingtin critical early development,...
The principal alpha subunit of voltage-gated sodium channels is associated with auxiliary beta subunits that modify channel function and mediate protein-protein interactions. We have identified a new termed beta4. Like the beta1-beta3 subunits, beta4 contains cleaved signal sequence, an extracellular Ig-like fold, transmembrane segment, short intracellular C-terminal tail. Using TaqMan reverse transcription-PCR analysis, in situ hybridization, immunocytochemistry, we show widely distributed...
Linaclotide is a minimally absorbed agonist of guanylate cyclase-C (GUCY2C or GC-C) that reduces symptoms associated with irritable bowel syndrome constipation (IBS-C). Little known about the mechanism by which linaclotide abdominal pain in patients IBS-C.We determined effects on colonic sensory afferents healthy mice and those chronic visceral hypersensitivity. We assessed transmission measuring activation dorsal horn neurons spinal cord response to noxious colorectal distention. Levels...
Abstract Treatment of chronic wounds such as diabetic with large volumes biofluids is a significant clinical challenge due to ischemia caused by localized edema. To alleviate edema and stimulate angiogenesis, four‐layer composite dressing designed micropore array modified Janus membrane for self‐pumping bioactive ion backflow, superabsorbent layer high capacity water absorption, containing bioglass stimulating angiogenesis. The not only allows wound exudates transport from bed the dressing,...
Abstract Huntington's disease (HD) is an autosomal dominant disorder characterized by involuntary movements, dementia, and progressive, global, but regionally accentuated, brain atrophy. The affects the striatum most severely. An expansion of a trinucleotide repeat on chromosome 4p16.3 within coding region gene termed IT15 has been identified as mutation causing HD. normal function mechanisms which presence cause HD are unknown. Although expression detected in brain, well other organ...
Fatty acids are a major source of energy for cardiac myocytes. Changes in fatty acid metabolism have been implicated as causal diabetes and disease. The mechanism by which long chain (LCFAs) enter myocytes is not well understood but appears to occur predominantly protein-mediated transport. Here we report the cloning, expression pattern, subcellular localization novel member transport protein (FATP) family termed FATP6. FATP6 principally expressed heart where it predominant FATP member....
Leukocytes are central regulators of inflammation and the target cells therapies for key diseases, including autoimmune, cardiovascular, malignant disorders. Efficient in vivo delivery small interfering RNA (siRNA) to immune could thus enable novel treatment strategies with broad applicability. In this report, we develop systemic methods siRNA encapsulated lipid nanoparticles (LNP) durable potent interference (RNAi)-mediated silencing myeloid cells. This work provides first demonstration...
Plant growth and architecture is regulated by the polar distribution of hormone auxin. Polarity flexibility this process provided constant cycling auxin transporter vesicles along actin filaments, coordinated a positive auxin-actin feedback loop. Both transport vesicle are inhibited synthetic inhibitors, such as 1-N-naphthylphthalamic acid (NPA), counteracting effect auxin; however, underlying targets mechanisms unclear. Using NMR, we map NPA binding surface on Arabidopsis thaliana ABCB...
The Kv4 A-type potassium currents contribute to controlling the frequency of slow repetitive firing and back-propagation action potentials in neurons shape potential heart. exhibit rapid activation inactivation are specifically modulated by K-channel interacting proteins (KChIPs). Here we report discovery functional characterization a modular suppressor (KIS) domain located first 34 aa an additional KChIP (KChIP4a). Coexpression KChIP4a with alpha-subunits abolishes fast various cell types,...
Abstract Background The analyses of protein synthesis, accumulation and regulation during grain development in wheat are more complex because its larger genome size compared to model plants such as Arabidopsis rice. In this study, grains from two cultivars Jimai 20 Zhoumai 16 with different gluten quality properties were harvested at five stages, used displayed variable expression patterns proteins. Results Proteome characterization Chinese bread was investigated by 2-DE tandem...
Wheat (Triticum aestivum L.) is one of the oldest cultivated crops and second most important food crop in world. Seed germination key developmental process plant growth development, poor directly affects subsequent grain yield. In this study, we performed first dynamic proteome analysis wheat seed using a two-dimensional differential gel electrophoresis (2D-DIGE)-based proteomic approach. A total 166 differentially expressed protein (DEP) spots representing 73 unique proteins were...
Roots, leaves, and intermediate sections between roots leaves (ISRL) of wheat seedlings show different physiological functions at the protein level. We performed first integrative proteomic analysis tissues drought-tolerant cultivar Hanxuan 10 (HX-10) drought-sensitive Chinese Spring (CS) during a simulated drought recovery. Differentially expressed proteins (DEPs) in (122), ISRLs (146), (163) showed significant changes expression response to stress Numerous DEPs associated with cell defense...
The drought-tolerant 'Ningchun 47' (NC47) and drought-sensitive 'Chinese Spring' (CS) wheat (Triticum aestivum L.) cultivars were treated with different PEG6000 concentrations at the three-leaf stage. An analysis on physiological proteomic changes of seedling in response to drought stress was performed. In total, 146 differentially accumulated protein (DAP) spots separated recognised using two-dimensional gel electrophoresis. 101 DAP representing 77 unique proteins identified by...
As an abundant ROS, hydrogen peroxide (H2O2) plays pivotal roles in plant growth and development. In this work, we conducted for the first time iTRAQ-based quantitative proteomic analysis of wheat seedling under different exogenous H2O2 treatments. The seedlings roots was significantly restrained by increased concentration stress. Malondialdehyde, soluble sugar, proline contents as well peroxidase activity with increasing levels. A total 3 425 proteins were identified iTRAQ, which 157 showed...