A5068118830- Immune cells in cancer
- Mast cells and histamine
- Congenital gastrointestinal and neural anomalies
- Clinical Nutrition and Gastroenterology
- Asthma and respiratory diseases
- Phagocytosis and Immune Regulation
- Ion Channels and Receptors
- Nicotinic Acetylcholine Receptors Study
- Gastrointestinal motility and disorders
- Immune Cell Function and Interaction
- Enhanced Recovery After Surgery
- Neurological Disease Mechanisms and Treatments
- Eosinophilic Esophagitis
- Immune responses and vaccinations
- CAR-T cell therapy research
- IL-33, ST2, and ILC Pathways
- Vagus Nerve Stimulation Research
- Autophagy in Disease and Therapy
- Beetle Biology and Toxicology Studies
- Immune Response and Inflammation
- Infant Nutrition and Health
- Cancer Immunotherapy and Biomarkers
- Diet and metabolism studies
- Endometriosis Research and Treatment
- Sarcoma Diagnosis and Treatment
KU Leuven
2021-2025
VIB-KU Leuven Center for Cancer Biology
2024
Centre d’Immunologie de Marseille-Luminy
2020
Inserm
2019
Centre National de la Recherche Scientifique
2019
Aix-Marseille Université
2019
Experimental and clinical evidence suggests that tumor-associated macrophages (TAMs) play important roles in cancer progression. Here, we have characterized the ontogeny function of TAM subsets a mouse model metastatic ovarian is representative for visceral peritoneal metastasis. We show omentum critical premetastatic niche development invasive disease this define unique subset CD163+ Tim4+ resident omental responsible spread cells. Transcriptomic analysis showed were phenotypically distinct...
Tumor-associated macrophages (TAMs) play critical roles in tumor progression but are also capable of contributing to antitumor immunity. Recent studies have revealed an unprecedented heterogeneity among TAMs both human cancer and experimental models. Nevertheless, we still understand little about the contribution different TAM subsets progression. Here, demonstrate that CD163-expressing specifically maintain immune suppression model melanoma is resistant anti-PD-1 checkpoint therapy....
Uterine leiomyosarcomas (uLMS) are aggressive tumours with poor prognosis and limited treatment options. Although immune checkpoint blockade (ICB) has proven effective in some 'challenging-to-treat' cancers, clinical trials showed that uLMS do not respond to ICB. Emerging evidence suggests aberrant PI3K/mTOR signalling can drive resistance We therefore explored the relevance of pathway for ICB pharmacological inhibition this sensitise these
Macrophages are innate immune cells that play key roles during both homeostasis and disease. Depending on the microenvironmental cues sensed in different tissues, macrophages known to acquire specific phenotypes exhibit unique features that, ultimately, orchestrate tissue homeostasis, defense, repair. Within tumor microenvironment, referred as tumor-associated (TAMs) constitute a heterogeneous population. Like their resident counterpart, TAMs plastic can switch function phenotype according...
ABSTRACT Introduction Postoperative ileus (POI) is an iatrogenic disorder marked by temporary impaired gastrointestinal (GI) motility post‐abdominal surgery. Surgical handling of the intestine activates resident macrophages (Mfs), leading to inflammatory cytokine release and leukocyte recruitment into muscularis , which compromises intestinal contractility. The mechanisms behind this activation are unclear. Recent studies suggest peritoneal Mfs, particularly large (LPMs), might play a role...
Background: We previously showed increased susceptibility to dextran sulfate sodium (DSS)-induced colitis in vagotomized mice. Here, we evaluated whether vagus nerve stimulation (VNS) is able reduce the severity of DSS and aimed unravel mechanism involved. Methods: Colitis was induced wild type mice by 2.5% administration drinking water for 5 days. VNS (5 Hz, 1 ms, mA) applied day prior after 4 days evaluate changes epithelial integrity inflammatory response, respectively. Epithelial...
Gut mast cells are key players in infection and inflammation, as well homeostasis. Mast regulate gastrointestinal (GI) function by controlling vascular epithelial permeability, interacting with the immune system enteric nervous system. Mucosal (MCT) connective tissue (MCTC) coexist tract, but located distinct microanatomical niches. However, little is known about transcriptional heterogeneity of human intestinal cells. Additionally, whether niches instruct cell phenotypes gut currently...
Summary Correct development and maturation of the enteric nervous system (ENS) is critical for survival. Early in life, ENS requires significant refinement order to adapt evolving needs tissue, changing from milk solid food at time weaning. Here, we demonstrate that resident macrophages muscularis externa, MMϕ, refine early life by pruning synapses phagocytosing abundant neurons. After weaning, MMϕ continue closely interact with ENS, acquire a microglia-like phenotype are crucial survival Of...