A5013631811- Gastrointestinal motility and disorders
- Immune Cell Function and Interaction
- Dermatology and Skin Diseases
- Cancer, Hypoxia, and Metabolism
- Gut microbiota and health
- Immune cells in cancer
- T-cell and B-cell Immunology
- Ion Channels and Receptors
- Infant Health and Development
- IL-33, ST2, and ILC Pathways
- Mast cells and histamine
- Asthma and respiratory diseases
- Aluminum toxicity and tolerance in plants and animals
- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Lipid metabolism and disorders
- Eosinophilic Esophagitis
- Nasal Surgery and Airway Studies
- Eicosanoids and Hypertension Pharmacology
- Urticaria and Related Conditions
- Cancer Cells and Metastasis
- Nanoplatforms for cancer theranostics
- Stress Responses and Cortisol
- Food Allergy and Anaphylaxis Research
- Therapeutic Uses of Natural Elements
KU Leuven
2021-2025
Queen Elizabeth Hospital Birmingham
2024
Université Libre de Bruxelles
2017-2022
Follicular helper T cells (Tfh) have been identified as the primary cell subpopulation regulating B responses in germinal centers, thus supporting high-affinity antibody production. Among transcription factors orchestrating Tfh differentiation and function, role played by proto-oncogene c-Maf remains poorly characterized. We report herein that selective loss of expression compartment results defective development response to both antigen/adjuvant vaccinations commensal intestinal bacteria....
Objectives Clinical studies revealed that early-life adverse events contribute to the development of IBS in adulthood. The aim our study was investigate relationship between prenatal stress (PS), gut microbiota and visceral hypersensitivity with a focus on bacterial lipopeptides containing γ-aminobutyric acid (GABA). Design We developed model PS mice evaluated, adult offspring, colorectal distension (CRD), colon inflammation, barrier function taxonomy. quantified production GABA by mass...
We recently showed that a bacterial infection can break oral tolerance to food and lead IgE-dependent mast cell activation food-induced abdominal pain, which could constitute an important pathogenic mechanism in post-infectious irritable bowel syndrome (IBS). Here, we investigated whether similar immune mechanisms response psychological stress food-evoked pain signaling, thus potentially explain the pathophysiology larger group of patients with IBS. Mice were exposed ovalbumin (OVA) during...
Background Mast cell activation is an important driver of abdominal pain in irritable bowel syndrome (IBS). While evidence supports the role IgE-mediated mast visceral development IBS, pseudoallergic MRGPRX2-mediated this process remains unknown. Objective We investigated whether plays a patients with IBS. Design MRGPRX2 expression cells and other immune was characterised across colon layers using flow cytometry. evaluated agonists trigger degranulation transient receptor potential vanilloid...
INTRODUCTION: Changes in the composition of gut microbiota have been associated with development irritable bowel syndrome (IBS). However, to what extent specific bacterial species relate clinical symptoms remains poorly characterized. We investigated relevance linked increased proteolytic activity, histamine production, and superantigen (SAg) production patients IBS. METHODS: Fecal (n = 309) nasal 214) samples were collected from IBS healthy volunteers (HV). Clinical transit time evaluated....
Gut mast cells are key players in infection and inflammation, as well homeostasis. Mast regulate gastrointestinal (GI) function by controlling vascular epithelial permeability, interacting with the immune system enteric nervous system. Mucosal (MCT) connective tissue (MCTC) coexist tract, but located distinct microanatomical niches. However, little is known about transcriptional heterogeneity of human intestinal cells. Additionally, whether niches instruct cell phenotypes gut currently...
RORγt-expressing Tregs form a specialized subset of intestinal CD4+ Foxp3+ cells which is essential to maintain gut homeostasis and tolerance commensal microbiota. Recently, c-Maf emerged as critical factor in the regulation RORγt expression Tregs. However, aside from signaling, signaling pathways involved differentiation RORγt+ their possible interplay with this process are largely unknown. We show that Treg development controlled by positive well negative signals. Along signals derived...
The oxygen sensor prolyl hydroxylase domain 2 (PHD2) plays an important role in cell hypoxia adaptation by regulating the stability of HIF proteins (HIF1α and HIF2α) numerous types, including T lymphocytes. on immune cells, particularly regulatory (Treg) function, has not been fully elucidated. purpose our study was to evaluate PHD2 regulation Treg phenotype function. We demonstrate herein that selective ablation expression (PHD2ΔTreg mice) leads a spontaneous systemic inflammatory syndrome,...
Objectives Irritable bowel syndrome (IBS) is the most frequently diagnosed functional gastrointestinal disorder, with a prevalence of up to 25% global population. IBS patients suffer from abnormal abdominal pain, or visceral hypersensitivity (VHS), associated altered habits in absence an organic detectable cause. The pathophysiology disease incompletely understood, but dysregulation brain-gut axis well established IBS.Methods onset mainly triggered by infectious gastroenteritis,...
Abstract RORγt-expressing Tregs form a specialized subset of intestinal CD4 + Foxp3 cells which is essential to maintain gut homeostasis and tolerance commensal microbiota. Recently, c-Maf emerged as critical factor in the regulation RORγt expression Tregs. However, aside from signaling, signaling pathways involved differentiation their possible interplay with this process are largely unknown. We show that Treg development controlled by positive well negative signals. Along signals derived...
Abstract The oxygen sensor PHD2 (prolyl hydroxylase domain 2) plays an important role in cell hypoxia adaptation by regulating the stability of HIF proteins (HIF1α and HIF2α) numerous types including T lymphocytes. on immune cells, particular regulatory (Treg) function, has not been fully elucidated. purpose our study was to evaluate regulation Treg phenotype function. We demonstrate herein that selective ablation expression (PHD2 ΔTreg mice) leads a spontaneous systemic inflammatory...