A5018699102- Adipose Tissue and Metabolism
- Diet and metabolism studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Regulation of Appetite and Obesity
- Tryptophan and brain disorders
- Diabetes and associated disorders
- Misinformation and Its Impacts
- Cardiovascular Health and Risk Factors
- Zebrafish Biomedical Research Applications
- Macrophage Migration Inhibitory Factor
- Vaccine Coverage and Hesitancy
- Stress Responses and Cortisol
- Animal Virus Infections Studies
- interferon and immune responses
- Renin-Angiotensin System Studies
- Phagocytosis and Immune Regulation
- Stoma care and complications
- Adipokines, Inflammation, and Metabolic Diseases
- Frailty in Older Adults
- Plant and Fungal Species Descriptions
- Plant Diversity and Evolution
- Chronic Kidney Disease and Diabetes
- Cardiovascular Disease and Adiposity
- Dietary Effects on Health
Huazhong University of Science and Technology
2024
Sichuan Agricultural University
2021-2023
Yale University
2020-2022
Inner Mongolia University
2019
Chinese PLA General Hospital
2011
Highlights•Liver injury in patients with COVID-19 is associated elevated IL-6 and coagulopathy.•Patients exhibit hepatic endotheliopathy which liver injury.•IL-6 trans-signaling causes sinusoidal endothelial cells.AbstractBackground AimsCOVID-19 interleukin-6 (IL-6). We hypothesized that cells (LSECs) leads to (a proinflammatory procoagulant state) COVID-19.MethodsCoagulopathy, endotheliopathy, alanine aminotransferase (ALT) were retrospectively analyzed a subset (n = 68), followed by larger...
Increasing age is the strongest predictor of risk COVID-19 severity and mortality. Immunometabolic switch from glycolysis to ketolysis protects against inflammatory damage influenza infection in adults. To investigate how compromises defense coronavirus infection, whether a pro-longevity ketogenic diet (KD) impacts immune surveillance, we developed an aging model natural murine beta (mCoV) with mouse hepatitis virus strain-A59 (MHV-A59). When inoculated intranasally, mCoV pneumotropic...
Meal ingestion increases body temperature in multiple species, an effect that is blunted by obesity. However, the mechanisms responsible for these phenomena remain incompletely understood. Here we show refeeding plasma leptin concentrations approximately 8-fold 48-hour-fasted lean rats, and this normalization of stimulates adrenomedullary catecholamine secretion. Increased adrenal medulla-derived catecholamines were necessary sufficient to increase postprandially, a process required both...
Genetic predisposition to coronavirus disease 2019 (COVID-19) may contribute its morbidity and mortality. Because cytokines play an important role in multiple phases of infection, we examined whether commonly occurring, functional polymorphisms macrophage migration inhibitory factor (MIF) are associated with COVID-19 infection or severity.To determine associations common MIF symptomatic severity.This retrospective case-control study utilized 1171 patients from three tertiary medical centers...
The antiviral and pathological potential of type I III interferons during coronavirus infection remains poorly defined, opposite findings have been reported. We report that both anticoronaviral activities, but their potency organ specificity differ.
Abstract Introduction Pyrovalerone (4‐methyl‐β‐keto‐prolintane) is a synthetic cathinone (beta‐keto‐amphetamine) derivative. Cathinones are concern as drugs of abuse, related street such methylenedioxypyrovalerone have garnered significant attention. The primary mechanism action cathinones to inhibit reuptake transporters (dopamine and norepinephrine) in reward centers the central nervous system. Methods We measured bioenergetic, behavioral, molecular responses pyrovalerone (nM‐µM) zebrafish...
SUMMARY Increasing age is the strongest predictor of risk COVID-19 severity. Unregulated cytokine storm together with impaired immunometabolic response leads to highest mortality in elderly infected SARS-CoV-2. To investigate how aging compromises defense against COVID-19, we developed a model natural murine beta coronavirus (mCoV) infection mouse hepatitis virus strain MHV-A59 (mCoV-A59) that recapitulated majority clinical hallmarks COVID-19. Aged mCoV-A59-infected mice have increased and...
Summary Emerging clinical data demonstrates that COVID-19, the disease caused by SARS-CoV2, is a syndrome variably affects nearly every organ system. Indeed, heterogeneity of COVID-19 ranges from relatively asymptomatic to severe with death resultant multiple constellations failures. In addition genetics and host characteristics, it likely viral dissemination key determinant manifestation. Given complexity expression, one major limitation in current animal models ability capture this due...
Malnutrition is a critical issue among older inpatients, yet limited large-scale research related to this has been conducted in China. This study aimed examine the nutritional status and support of inpatients China, assess associations between disease categories malnutrition on admission, explore effective intervention.
<title>Abstract</title> This study aims to explore the relationship between perception of health information in different populations during epidemic period, and provide empirical for improvement public policies. 4704 participants were selected from 8 provinces eastern, central western China. A questionnaire was designed including demographic information, household variables, perceptions resident information. Propensity score matching path analysis data used. For both healthy suspect groups,...
As a kind of human betacoronavirus, SARS-CoV-2 has endangered globally public health. January 2021, the virus had resulted in 2,209,195 deaths. By studying evolution trend and characteristics 265 strains United States from to March, it is found that can be divided into six clades, USA clade-1, clade-2, clade-3, clade-4, clade-5, clade-6, which US clade-1 may most ancestral clade, clade-2 an interim clade other three clades have similar codon usage pattern, while clade-6 newest adaptable...
Abstract The taxonomic status determination of populations plays a crucial role in the conservation and management global biodiversity. Celastrales–Oxalidales–Malpighiales (COM) clade, an important component Rosidae, holds significant position within angiosperms. In this study, systematic phylogenetic analyses were conducted on mitochondrial genomes, chloroplast nuclear genomes all sequenced species COM clade using three different methods. Phylogenetic analysis eight conserved genes from 34...
Objective To investigate of subjects' understanding and emphasis on “prehypertension” “high normal blood pressure” with simple questionnaire in order to carry out effective education healthy pressure.Methods A cross-sectional study was conducted among 202 subjects ( 144 males 58 females)hospitalized our center.All were requested fill a designed by researchers.The response rate 100％.Results Subjects who considered that could progress hypertension more than those hypertension,the difference...
In this study, Perry et al used their well-established animal model of fasted rats to unravel how feeding induces hyperthermia and energy expenditure.