Amyotrophic lateral sclerosis (ALS) is caused by a progressive degeneration of motor neurons. The cause sporadic ALS not known, but 1–2% all cases are familial and mutations in the copper–zinc superoxide dismutase (SOD1) gene. Transgenic SOD1 mice serve as transgenic mouse model for these cases. Glial cell-derived neurotrophic factor (GDNF) has potent trophic effect on Clinical trials which growth factors have been systemically administered to patients effective, owing part short half-life...

OBJECTIVE: We aimed to compare affect and behavior of 3 groups nonanemic 4-year-old children: children with iron-deficiency anemia (IDA) in infancy whose was not corrected before 24 months (chronic IDA) (n = 27); IDA (corrected 70); who were at 64). METHOD: Mother child dyads invited a local clinic room. Children's social referencing, wariness, frustration-tolerance behavior, observed during set situations encountered the laboratory, including free play, stranger approach, novel toy, delay...

Abstract Background: Non-communicable chronic diseases have become the leading causes of disease burden worldwide. The trends and “metabolic associated fatty liver disease” (MAFLD) are unknown. We aimed to investigate cardiovascular renal burdens in adults with MAFLD non-alcoholic (NAFLD). Methods: Nationally representative data were analyzed including from 19,617 non-pregnant aged ≥20 years cross-sectional US National Health Nutrition Examination Survey periods, 1999 2002, 2003 2006, 2007...

Previous studies have implicated the uric acid to high-density lipoprotein cholesterol (HDL-C) ratio (UHR) was associated with type 2 diabetes. However, association between UHR and diabetes-related vascular damages is still unclear.The total of 4551 patients diabetes from cross-sectional Environmental Pollutant Exposure Metabolic Diseases in Shanghai study (METAL study) were enrolled. calculated as HDL-C ratio. Cardiovascular disease (CVD) defined previously diagnosed stroke, coronary heart...

Polycyclic aromatic hydrocarbons (PAHs) are widely used in materials science, optoelectronic devices, and supramolecular chemistry because of their unique extended π-conjugated structures. Among numerous PAHs, hexa-peri-hexabenzocoronene (HBC) is a prominent representative the all-benzene structural building blocks. The synthesis HBC using hexaphenylbenzene (HPB) considered most direct approach, requiring only intramolecular dehydrocyclization. In this study, we calculated complete reaction...

Electrocatalytic reduction of nitrate (NO3-, NO3RR) on single-atom copper catalysts (Cu-SACs) offers a sustainable approach to ammonia (NH3) synthesis using NO3- pollutants as feedstocks. Nevertheless, this process suffers from inferior NO3RR kinetics and nitrite accumulation owing the linear scaling relation limitations for SACs. To break these limitations, Cu-bearing tungsten oxide catalyst (Cu1/WO3) was developed, which mediated unique dual-driven process. Specifically, WO3 dissociated...

Electrocatalytic reduction of nitrate (NO3‐, NO3RR) on single‐atom copper catalysts (Cu‐SACs) offers a sustainable approach to ammonia (NH3) synthesis using NO3‐ pollutants as feedstocks. Nevertheless, this process suffers from inferior NO3RR kinetics and nitrite accumulation owing the linear scaling relation limitations for SACs. To break these limitations, Cu‐bearing tungsten oxide catalyst (Cu1/WO3) was developed, which mediated unique dual‐driven process. Specifically, WO3 dissociated...

Associations between sex hormones and vascular remodeling have been extensively studied, but the results vary widely among different races sex. We aimed to investigate whether total testosterone (TT), estrogen (E2), dehydroepiandrosterone (DHEA) associate with macrovascular complications diabetic kidney disease (DKD) community-dwelling patients diabetes.A of 4720 participants type 2 diabetes were recruited from Shanghai, China. Common carotid artery (CCA) plaques diameter assessed by...

A magnetic field, with the direction parallel to electric is applied repetitively unipolar positive nanosecond pulsed dielectric barrier discharge. The effect of field on plasma generated between two parallel-plate electrodes in quiescent air experimentally studied under different pulse repetition frequencies (PRFs). It indicated that only current rising front voltage occurs, and value increased by PRFs. discharge uniformity improved decrease PRF, this phenomenon also observed field. By...

The attraction and influx of monocytes into the retina has been considered a critical step in development diabetic retinopathy (DR). However, large population studies about association between peripheral blood monocyte levels, an inexpensive easily measurable laboratory index, DR are limited. Thus, we aimed to investigate levels DR.A total 3223 participants out 3277 adults with diabetes were enrolled from seven communities China this cross-sectional survey. Participants underwent several...

Abstract Objectives Famine exposure in early life was associated with type 2 diabetes, non-alcoholic fatty liver disease and metabolic syndrome, etc. But evidence famine insulin resistance beta cell dysfunction were limited. We aimed to investigate whether the association existed between adulthood. Methods In all, 7912 non-diabetic participants included this study, based on SPECT-China study. Participants fetal or childhood (birth year 1949–1962) group. Insulin estimated by homeostasis model...

Abstract Background: Prenatal and postnatal factors may have joint effects on cardiovascular health, we aimed to assess the association of birth weight ideal health metrics (ICVHMs) prospectively in adulthood with incident disease (CVD). Methods: In UK Biobank, 227,833 participants data ICVHM components without CVD at baseline were included. The ICVHMs included smoking, body mass index, physical activity, diet information, total cholesterol, blood pressure, hemoglobin A1c. Cox proportional...

Mutations of the neurofibromin gene (NF1) cause neurofibromatosis type 1 (NF1), a disease in which learning disabilities are common. Learning deficits also observed mice with heterozygous mutation Nf1 (Nf1(+/-)). Dysregulation regulated neurotransmitter release has been Nf1(+/-) mice. However, role presynaptic voltage-gated Ca(2+) channels mediating this not investigated. We investigated whether currents and transmitter were affected by reduced Hippocampal current density was greater neurons...

The surface charge distribution in a dielectric barrier discharge driven by repetitive pulse bias superimposed on AC voltage is measured using the Pockels effect of an electro-optic crystal. impact surface-breakdown characteristics investigated varying phase superimposition. It demonstrated that accumulation varies at different superimposition phases depending potential difference between two electrodes. accumulated positive/negative will facilitate following when polarity changes. In...

Abstract Wireless capsule endoscopy (WCE) is becoming more popular in clinical settings as a safe and painless gastrointestinal examination. Existing studies on automatic detection of lesions WCE images have the problems small dataset size uneven distribution numbers terms categories, which often leads to overfitting model severely limits performance improvement object network images. The traditional data enhancement methods such flipping local erasure limitations cannot achieve good...

InSbN p-n junctions prepared by N+ and Mg+ implantation into InSb wafers for long wavelength infrared photodetection are demonstrated the first time. The detection can be controlled monitoring implanted nitrogen. measured peak wavelengths consistent with bandgaps of alloys calculated using a 10-band k·p model based on In-N bond.

Dielectric barrier discharge (DBD) with better uniformity, excited by nanosecond pulses, is achieved within 8 mm air gap using a self-designed DBD structure in airflow. The characterized adding metal rod (MR) gap, which will produce local strong electric field and induce surface volume discharge. It observed from sequential single periodic images that the uniformity of starts electrode edge at airflow inlet moves gradually toward downstream under action When transmitted to nearby MR, stable...

The double burden of malnutrition (DBM), undernutrition in early life and an obesogenic environment later on, influences risk chronic disorders. Great Famine China from 1959 to1962 remarkable economic development the 1980s provided such a for large number people their 60s.We aimed to analyze effect status on association between famine exposure hyperuricemia adulthood.Participants numbering 12 666 were enrolled based Survey Prevalence East Metabolic Diseases Risk Factors (SPECT-China) Study...

Background: Hypertrophic scars can be caused by various injuries and lead to a decrease in quality of life those affected. This study was performed retrospectively our center investigate the safety effectiveness fractional micro-plasma radio-frequency treatment combined with ablative carbon dioxide (CO2) laser patients hypertrophic scar. Methods: retrospective single between January 2019 December 2020. All receiving treatment, CO2 or therapy both were recruited study. The participants then...

An experimental study of the effects airflow, magnetic field, and combination airflow with field on a nanosecond pulsed dielectric barrier discharge (DBD) in atmospheric air is presented. The DBD generated by an in-house designed structure (a metal rod inserted into traditional parallel-plate DBD). results show that application to can reinforce improve uniformity. When increases certain velocity, surface transform diffuse volume discharge. Moreover, static also enhance discharge, which...

The effect of flowing air on dielectric barrier discharge excited by alternating voltage was investigated high-speed video analysis and electrical measurements. still in filamentary mode air, the space-time distribution filaments changed airflow. With increase airflow velocity, shown top view images went through four phases, that is, spot-like distribution, line-like cotton-like stripe-like distribution. Accordingly, motion morphology side also presented phases: remaining straight between...