A5010772370- Heat shock proteins research
- Plant Gene Expression Analysis
- thermodynamics and calorimetric analyses
- Plant Disease Resistance and Genetics
- Wheat and Barley Genetics and Pathology
- Genetics and Plant Breeding
- Nanoplatforms for cancer theranostics
- Plant biochemistry and biosynthesis
- ATP Synthase and ATPases Research
- Photodynamic Therapy Research Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Protein Structure and Dynamics
- Horticultural and Viticultural Research
Dalian University of Technology
2024-2025
Henan University of Science and Technology
2016
Abstract Activating the pyroptosis pathway of tumor cells by photodynamic therapy (PDT) for immunogenic cell death (ICD) is considered a valid strategy in pursuit antitumor immunotherapy, but it remains huge challenge due to lack reliable design guidelines. Moreover, often overlooked that conventional PDT can exacerbate development immunosuppressive microenvironment, which apparently unfavorable clinical immunotherapy. The endoplasmic reticulum's (ER) pivotal role cellular homeostasis and...
Hsp70-Bim protein–protein interaction (PPI) is the most recently identified specific target in chronic myeloid leukemia (CML) therapy. Herein, we developed a new class of PPI inhibitors via scaffold hopping S1g-10, potent inhibitor thus far. Through structure–activity relationship (SAR) study, obtained biphenyl compound JL-15 with 5.6-fold improvement suppression (Kd = 123 vs 688 nM) and 4-fold water solubility (29.42 7.19 μg/mL) compared to S1g-10. It maintains comparable apoptosis...