A5018594479- Health disparities and outcomes
- Cardiac Health and Mental Health
- Sleep and related disorders
- Herpesvirus Infections and Treatments
- Obesity, Physical Activity, Diet
- Child Abuse and Trauma
- Cytomegalovirus and herpesvirus research
- Cardiac Arrest and Resuscitation
- Urticaria and Related Conditions
- Health, psychology, and well-being
- Physical Activity and Health
- Chronic Disease Management Strategies
- Circadian rhythm and melatonin
- Anesthesia and Neurotoxicity Research
- Air Quality and Health Impacts
- Spaceflight effects on biology
- Cardiovascular Health and Risk Factors
- Cardiovascular and exercise physiology
- Body Composition Measurement Techniques
- Climate Change and Health Impacts
- Sleep and Wakefulness Research
- Heavy Metal Exposure and Toxicity
- Health, Environment, Cognitive Aging
- Psychological Well-being and Life Satisfaction
- Acne and Rosacea Treatments and Effects
Guangzhou Medical University
2022-2024
University of North Carolina at Chapel Hill
2023-2024
Guangdong Academy of Medical Sciences
2022-2023
Guangdong Provincial People's Hospital
2022-2023
Abstract Aims To investigate the joint association of accelerometer-measured physical activity (PA) and sleep duration with mortality risk. Methods results A 7-day accelerometer recording was performed on 92 221 participants (age 62.4 ± 7.8 years; 56.4% women) from UK Biobank between February 2013 December 2015. We divided into three groups (short, normal, long), total volume PA levels according to tertiles (high, intermediate, low), moderate-to-vigorous (MVPA) two based World Health...
Abstract Background Both sleep duration and efficiency are essential for health outcomes. However, few studies have considered the effects of both on predicting risks mortality. This study investigated independent joint associations accelerometer-measured with all-cause cause-specific Methods The UK Biobank is a cohort over 500 000 individuals recruited between 2006 2010. included participants wearing wrist accelerometers 7 consecutive days February 2013 December 2015. Mortality was...
Physical activity (PA) is considered beneficial for lowering cardiovascular risks following type 2 diabetes mellitus (T2DM) and prediabetes, but existing evidence relies mainly on self-reported measurements. We aimed to describe the intensity-specific dose-response associations of PA sedentary behavior (SB) with macrovascular microvascular events among individuals T2DM prediabetes. This study included 11,474 prediabetes from UK Biobank. PA, including total moderate-to-vigorous intensity...
Background Individuals with type 2 diabetes mellitus (T2DM) are more vulnerable to social disconnection compared the general population; however, there few relevant studies investigating this issue. Aims To investigate whether isolation or loneliness may be associated subsequent risk of developing major adverse cardiovascular events, these associations vary according fatal and non-fatal outcomes how behavioural, psychological physiological factors mediate associations. Methods This...
Background We aimed to determine the associations of childhood maltreatment with incident heart failure in later life and explore potentially modifying effects genetic risk for on associations. Methods Results This cohort study included adults free at baseline enrolled between 2006 2010 UK Biobank. Childhood was retrospectively assessed online Trauma Screener 2016. Five types (range, 0-5), including physical abuse, neglect, emotional sexual were combined into a total score. A weighted...
Abstract Background It remains unknown how the patterns of change social isolation and loneliness are associated with onset cardiovascular disease (CVD) mortality. We aimed to investigate longitudinal association changes in incident CVD, all-cause mortality, CVD mortality subsequent cardiac function. Methods This prospective cohort study included 18,258 participants aged 38–73 years who participated visit 0 (2006–2010) 1 (2012–2013) using UK Biobank (mean age 57.1, standard deviation [SD]...
Background: Emerging evidence has linked childhood maltreatment with cardiovascular disease risk; however, the association between and cardiac arrhythmias remains unclear. Moreover, any genetic predispositions to atrial fibrillation (AF), a common arrhythmia associated an elevated risk of stroke, heart failure, mortality, that modify such associations have been undocumented.
Objectives The aim of this study was to investigate whether melatonin receptor type 1B (MTNR1B) rs10830963 polymorphism interacts with night shift work on the risk incident stroke. Methods This included individuals free stroke at baseline from UK Biobank. Night-shift assessed by self-reported questions. MTNR1B directly genotyped (CC, GC, and GG). Incident ascertained through hospital records death registries. Cox proportional hazards models were employed examine associations Results A total...
Aim Knowledge of how circadian rhythm influences brain health remains limited. We aimed to investigate the associations accelerometer‐measured rest‐activity (CRAR) with incident dementia, cognitive dysfunction, and structural abnormalities in general population underlying biological mechanisms. Methods Fifty‐seven thousand five hundred two participants aged over 60 years accelerometer data were included association CRAR incidental dementia. Non‐parametric parameters utilized, including...
Background: Herpes simplex virus type 2 (HSV-2) infection is prevalent and a significant public health problem. Understanding its epidemiology will help assess the current HSV-2 prevention efforts inform future interventions in China. Methods: We followed Cochrane PRISMA guidelines for systematic review included publications published Chinese English bibliographic systems until March 18 , 2023. synthesized seroprevalence, sero-incidence, proportions of isolated genital ulcer disease (GUD)...
Abstract Background Emerging evidence concerning the association of social isolation and loneliness with diabetes risk were inclusive. It remains unknown how isolation, loneliness, their change, associated onset type 2 diabetes. This study aimed to investigate trajectory developing across genetic risk. Methods We included 439,337 participants (mean age 56.3 ± 8.1 years) enrolled in UK Biobank who followed up until May 31, 2021. Social self-reported. In a longitudinal analysis, based on...