A5047396597- Pancreatitis Pathology and Treatment
- Phagocytosis and Immune Regulation
- Pancreatic function and diabetes
- Peptidase Inhibition and Analysis
- Mathematical Biology Tumor Growth
- Cancer Cells and Metastasis
- Endodontics and Root Canal Treatments
- Glioma Diagnosis and Treatment
- Dental Implant Techniques and Outcomes
- Ubiquitin and proteasome pathways
- Protein Degradation and Inhibitors
- Bone Tissue Engineering Materials
Huashan Hospital
2025
Fudan University
2025
Southern Medical University
2022-2023
Nanfang Hospital
2022-2023
General Hospital of Guangzhou Military Command
2023
Tumor organoids are important tools for cancer research, but current models have drawbacks that limit their applications predicting response to therapy. Here, we developed a fast, efficient, and complex culture system (IPTO, individualized patient tumor organoid) accurately recapitulates the cellular molecular pathology of human brain tumors. Patient-derived explants were cultured in induced pluripotent stem cell (iPSC)-derived cerebral organoids, thus enabling wide range tumors central...
Abstract Noninflammatory clearance of dying cells by professional phagocytes, termed efferocytosis, is fundamental in both homeostasis and inflammatory fibrosis disease but has not been confirmed to occur chronic pancreatitis (CP). Here, we investigated whether efferocytosis constitutes a novel regulatory target CP its mechanisms. PRSS1 transgenic ( Tg ) mice were treated with caerulein mimic development. Phospholipid metabolite profiling epigenetic assays performed models. The potential...
Abstract Background Noninflammatory clearance of dying cells by professional phagocytes, termed efferocytosis, is fundamental in both homeostasis and inflammatory fibrosis disease but has not been confirmed to occur chronic pancreatitis (CP). Here, we investigated whether efferocytosis constitutes a novel regulatory target CP its mechanisms. Methods PRSS1 transgenic ( Tg ) mice were treated with caerulein mimic development. Sphingomyelin metabolite profiling epigenetic assays performed...
Background: Noninflammatory clearance of dying cells by professional phagocytes, termed efferocytosis, is fundamental in both homeostasis and inflammatory fibrosis disease but has not been confirmed to occur chronic pancreatitis (CP). Here, we investigated whether efferocytosis constitutes a novel regulatory target CP its mechanisms.Methods: PRSS1 transgenic (PRSS1Tg) mice were treated with caerulein mimic development. Sphingomyelin metabolite profiling epigenetic assays performed PRSS1Tg...
Abstract Objective Acute pancreatitis (AP) is a common and unpredictable disease. Severity stratification prognostic prediction play an important role in reducing the mortality of AP improving its prognosis early stage. We aimed to establish clinical model by logistic regression analysis visualized nomogram. Methods A total 497 patients with Nanfang Hospital, Southern Medical University between January 2015 2018 were retrospectively collected. randomly (ratio = 7:3) divided into training...