A5017047904- Lung Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Lung Cancer Treatments and Mutations
- Radiation Therapy and Dosimetry
- Radiomics and Machine Learning in Medical Imaging
- Occupational and environmental lung diseases
- Breast Cancer Treatment Studies
- Lung Cancer Research Studies
- Medical Imaging Techniques and Applications
- Cancer Immunotherapy and Biomarkers
- BRCA gene mutations in cancer
- Prostate Cancer Diagnosis and Treatment
- Brain Metastases and Treatment
- Myasthenia Gravis and Thymoma
- Male Breast Health Studies
- Medical Imaging and Pathology Studies
- Radiation Dose and Imaging
- Neuroendocrine Tumor Research Advances
- Hepatocellular Carcinoma Treatment and Prognosis
- Esophageal and GI Pathology
- Gastroesophageal reflux and treatments
- Pleural and Pulmonary Diseases
- Prostate Cancer Treatment and Research
- Cancer Genomics and Diagnostics
- Meningioma and schwannoma management
Maastro Clinic
2017-2025
Maastricht University Medical Centre
2018-2025
Maastricht University
2017-2023
Universitair Ziekenhuis Leuven
2011-2023
KU Leuven
2009-2020
Nestlé (France)
2020
Vrije Universiteit Brussel
1991-2019
European Organisation for Research and Treatment of Cancer
2019
Cancer Trials Ireland
2018-2019
Breast International Group
2018-2019
Purpose To determine whether a dose of 78 Gy improves outcome compared with conventional 68 for prostate cancer patients treated three-dimensional conformal radiotherapy. Patients and Methods Between June 1997 February 2003, stage T1b-4 were enrolled onto multicenter randomized trial comparing Gy. stratified by institution, age, (neo)adjuvant hormonal therapy (HT), treatment group. Four groups (with specific radiation volumes) defined based on the probability seminal vesicle involvement. The...
Efficient workflows for adaptive proton therapy are of high importance. This study evaluated the possibility to replace repeat-CTs (reCTs) with synthetic CTs (sCTs), created based on cone-beam (CBCTs), flagging need plan adaptations in intensity-modulated (IMPT) treatment lung cancer patients.Forty-two IMPT patients were retrospectively included. For each patient, one CBCT and a same-day reCT Two commercial sCT methods applied; number correction (Cor-sCT), deformable image registration...
A genome-wide association study (GWAS) identified single-nucleotide polymorphisms (SNPs) at 1p11.2 and 14q24.1 (RAD51L1) as breast cancer susceptibility loci. The initial GWAS suggested stronger effects for both loci estrogen receptor (ER)-positive tumors. Using data from the Breast Cancer Association Consortium (BCAC), we sought to determine whether risks differ by ER, progesterone (PR), human epidermal growth factor 2 (HER2), grade, node status, tumor size, ductal or lobular morphology. We...
Purpose Automated techniques for estimating the contours of organs and structures in medical images have become more widespread a variety measures are available assessing their quality. Quantitative geometric agreement, example, overlap with gold‐standard delineation, popular but may not predict level clinical acceptance contouring method. Therefore, surrogate that relate directly to judgment contours, way they used routine workflows, need be developed. The purpose this study is propose...
Assessment of handgrip strength and fat-free mass provides quick objective information on muscle performance that might complement subjective World Health Organization Performance Status (WHO PS). We investigated to what extent the presence pre-treatment weakness low index (FFMI) additional prognostic top well-established factors (including WHO PS) in non-small cell lung cancer (NSCLC) patients selected for curative-intent (chemo)radiation.Prospectively, with early locally advanced NSCLC...
Purpose Adjuvant treatments after breast-conserving surgery (BCS) for ductal carcinoma in situ to prevent local relapse are considered standard of care. However, patient selection increased morbidity without proven survival benefit remains a challenge. To predict the risk ipsilateral breast tumor (IBTR) BCS, Memorial Sloan-Kettering Cancer Center (MSKCC) developed nomogram. The aim this study was develop our own prediction model IBTR and provide an external validation MSKCC Methods From 1973...
Nodal upstaging is a quality indicator for oncological thoracic surgery and found in up to 25% of patients with clinical stage I (cStage-I) non-small-cell lung cancer (NSCLC). In large retrospective series, lower N1 was reported after video-assisted (VATS) resections. We studied the impact central primary tumour location on nodal cStage-I NSCLC. Consecutive operated NSCLC were selected from prospectively managed surgical database. Tumour classified as if lesion visible during standard video...
Background and purposeUser-adjustments after deep-learning (DL) contouring in radiotherapy were evaluated to get insight real-world editing during clinical practice. This study assessed the amount, type spatial regions of auto-contouring for organs-at-risk (OARs) routine workflow patients thorax region.Materials methodsA total 350 lung cancer 362 breast patients, contoured between March 2020 2021 using a commercial DL-contouring method followed by manual adjustments retrospectively analyzed....
Proton therapy of moving targets is considered a challenge. At Maastro, we started treating lung cancer patients with proton in October 2019. In this work, summarise the developed treatment strategies and gained clinical experience from physics point view. We report on our approaches to treat Mevion Hyperscan S250i machine. classify as small movers (tumour movement ≤ 5 mm) or large > mm). The preferred beam configuration has evolved over years treatment, currently mostly two three directions...