A5112606683- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Radiation Therapy and Dosimetry
- Head and Neck Cancer Studies
- Advanced X-ray and CT Imaging
- MRI in cancer diagnosis
- Effects of Radiation Exposure
- Ultrasound and Hyperthermia Applications
- Radiation Dose and Imaging
- Medical Imaging and Analysis
- Prostate Cancer Diagnosis and Treatment
- Radiation Effects and Dosimetry
- Particle Accelerators and Free-Electron Lasers
- Nuclear Physics and Applications
- Advances in Oncology and Radiotherapy
- Health Systems, Economic Evaluations, Quality of Life
- Glioma Diagnosis and Treatment
- Musculoskeletal Disorders and Rehabilitation
- Lung Cancer Treatments and Mutations
- Digital Radiography and Breast Imaging
- Central Venous Catheters and Hemodialysis
- Advanced Neuroimaging Techniques and Applications
Odense University Hospital
2015-2024
University of Southern Denmark
2010-2024
Kongsberg Innovasjon (Norway)
2016-2019
National Agency for New Technologies, Energy and Sustainable Economic Development
2018
The University of Sydney
2016
Onkologikoa
2011-2015
Treatment planning is time‐consuming and the outcome depends on person performing optimization. A system that automates treatment could potentially reduce manual time required for optimization also provide a method to variation between persons radiation dose (dosimetrist) improve overall plan quality. This study evaluates performance of Auto‐Planning module has recently become clinically available in Pinnacle 3 therapy system. Twenty‐six delivered head neck plans were reoptimized with...
Purpose: A 1.5 T MR Linac (MRL) has recently become available. MRL treatment workflows (WF) include online plan adaptation based on daily images (MRI). This study reports initial clinical experiences after five months of use in terms patient compliance, cases, WF timings, and dosimetric accuracy.Method materials: Two different were used dependent the situation day; Adapt To Position (ATP) where reference position is adjusted rigidly to match targets OARs, Shape (ATS), a new created anatomy...
With daily, MR-guided online adapted radiotherapy (MRgART) it may be possible to reduce the PTV in pelvic RT. This study investigated potential reduction normal tissue complication probability (NTCP) of MRgART compared standard for high-risk prostate cancer.Twenty patients treated with 78 Gy and 56 elective lymph nodes were included. VMAT plans generated clinical margins. Additionally planning MR, had three MRI scans during treatment simulate an MRgART. A reference plan margins determined...
Delineation accuracy of the gross tumor volume (GTV) in radiotherapy planning for head and neck (H&N) cancer is affected by computed tomography (CT) artifacts from metal implants which obscure identification as well organs at risk (OAR). This study investigates impact artifact reduction (MAR) H&N patients terms delineation consistency dose calculation precision radiation treatment planning.Tumor OAR delineations were evaluated CT scans eleven oropharynx with streaking region preceding...
The quality of radiotherapy planning has improved substantially in the last decade with introduction intensity modulated radiotherapy. purpose this study was to analyze plan and efficacy automatically (AU) generated VMAT plans for inoperable esophageal cancer patients.Thirty-two consecutive patients originally treated manually (MA) volumetric arc therapy (VMAT) were retrospectively replanned using an auto-planning engine. All optimized one full 6MV giving 60 Gy primary target 50 elective...
Radiation-induced mucositis is a severe acute side effect, which can jeopardize treatment compliance and cause weight loss during treatment. The study aimed to develop robust models predict the risk of mucositis.Mucosal toxicity scores were prospectively recorded for 802 consecutive Head Neck (H&N) cancer patients dichotomised into non-severe event (grade 0-2) 3+) groups. Two different model approaches utilised evaluate robustness models. These used LASSO Best Subset selection combined with...
In this study we have evaluated the accuracy of automatic, deformable structure propagation from planning CT and MR scans for daily online plan adaptation linac (MRL) treatment, which is an important element to minimize re-planning time reduce risk misrepresenting target due pressure.For 12 high-risk prostate cancer patients treated pelvic lymph nodes, structures organs at were delineated on both propagated using registration three T2 weighted acquired during treatment course. Generated...
The purpose of this study was to quantify the set-up errors patient positioning during IGRT and correlate patient-specific factors such as weight, height, BMI, weight loss.Thirty four consecutively treated head-and-neck cancer patients (H&N) 20 lung were investigated. Patients positioned using customized immobilization devices consisting vacuum cushions thermoplastic shells. Treatment given on an Elekta Synergy accelerator. Cone-beam acquisitions obtained according a standardized Action...
Deformable image registration (DIR) and contour propagation are used in daily online adaptation for hybrid MRI linac (MRL) treatments. The accuracy of the propagated contours may vary depending on chosen workflow (WF), affecting amount required manual corrections. This study investigated impact three different WFs propagations produced by a clinical treatment planning system high-field MRL head neck cancer patients.Seventeen patients referred curative radiotherapy oropharyngeal underwent...
Elekta accelerators controlled by the current clinically used accelerator control system, Desktop 7.01 (D7), uses binned variable dose rate (BVDR) for volumetric modulated arc therapy (VMAT). The next version of treatment system (Integrity) supports continuously (CVDR) as well BVDR. Using CVDR opposed to BVDR VMAT has potential reducing time but may lead lower dosimetric accuracy due faster moving parts. D7 and a test Integrity, differences in ability accelerator, efficiency, between two...
Background. Volumetric modulated arc therapy (VMAT) for treatment of non-small cell lung cancer (NSCLC) patients potentially changes the risk radiation-induced pneumonitis (RP) compared to intensity radiation (IMRT) if dose healthy is changed significantly. In this study, clinical IMRT plans were used as starting point VMAT optimization and differences in estimates RP between two plan types evaluated. Material methods. Fifteen NSCLC prescribed 66 Gy 2 fractions planned with subsequently...