A5048762599- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Advanced Radiotherapy Techniques
- Cardiac pacing and defibrillation studies
- Management of metastatic bone disease
- Cardiovascular Function and Risk Factors
- Cardiomyopathy and Myosin Studies
- Advances in Oncology and Radiotherapy
- Pancreatic and Hepatic Oncology Research
- Muscle activation and electromyography studies
- Effects of Radiation Exposure
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Anorectal Disease Treatments and Outcomes
- Metastasis and carcinoma case studies
- Neurological disorders and treatments
- Cardiac Imaging and Diagnostics
University of Copenhagen
2016-2025
Copenhagen University Hospital
2023-2025
Gentofte Hospital
2012-2024
Online adaptive radiotherapy (oART) potentially spares OARs as PTV margins are reduced. This study evaluates dosimetric benefits, compared to standard non-adaptive (non-ART), target propagation methods, and first clinical treatments of CBCT-guided oART anal cancer.Treatment plans with non-ART reduced were retrospectively generated for 23 consecutive patients cancer. For five randomly selected among the patients, weekly sessions simulated, where targets either deformed or rigidly propagated....
AimsPre-implant assessment of longitudinal mechanical dyssynchrony using cross-correlation analysis (XCA) was tested for association with long-term survival and compared other tissue Doppler imaging (TDI)-derived indices.
Only 30% of patients receiving an implantable cardioverter defibrillator (ICD) for primary prevention receive appropriately therapy. We sought to investigate the value tissue Doppler imaging (TDI) predict ventricular tachycardia (VT), fibrillation (VF), and cardiovascular mortality (CVD) in with ICD. In total, 151 ICD meeting criteria no history arrhythmias were included. All participants examined by conventional 2D echocardiography TDI echocardiography. Longitudinal systolic ( s ′), early...
Abstract Background Chemo-radiotherapy with curative intent for anal cancer has high complete remission rates, but acute treatment-related gastrointestinal (GI) toxicity is significant. Toxicity occurs due to irradiation of surrounding normal tissue. Current radiotherapy requires the addition large planning margins radiation field ensure target coverage regardless considerable organ motion in pelvic region. This increases irradiated volume and dose tissue thereby toxicity. Online adaptive...
Patient-reported outcome (PRO) and National Cancer Institute-Common Terminology Criteria for Adverse Events (NCI-CTCAE) data patients with squamous cell carcinoma of the anus (SCCA) treated modern radiation therapy (RT) are lacking. The primary aim this study was to report bowel bladder PRO NCI-CTCAE SCCA 1 year after RT.From 2015 2020, we included in a prospective Danish national study. Data were collected before treatment (PT) (1Y) using version 4.0, as well European Organisation Research...
<title>Abstract</title> <bold>Background</bold> Chemo-radiotherapy with curative intent for anal cancer has high complete remission rates, but acute treatment-related gastrointestinal (GI) toxicity is significant. Toxicity occurs due to irradiation of surrounding normal tissue. Current radiotherapy requires the addition large planning margins radiation field ensure target coverage regardless considerable organ motion in pelvic region. This increases irradiated volume and dose tissue thereby...
Abstract Background First‐line platinum‐based therapy for advanced squamous cell carcinomas of the anal canal (SCCA) implies a risk substantial side effects, and data on second‐line treatment options are limited. Paclitaxel Capecitabine well‐known regimen with moderate toxicity profile, but its efficacy has not been evaluated. Methods We conducted retrospective study using Danish Hospital Registers patients treated inoperable, recurrent, or metastatic SCCA in Denmark, between January 2000...
Background: Only 30% of patients receiving an implantable cardioverter defibrillator (ICD) for primary prevention respond appropriately to this therapy. The purpose study was investigate the value Tissue Doppler Imaging (TDI) Echocardiography at predicting appropriate ICD therapy and cardiovascular mortality (CVD) in with ICD. Methods: In total, 151 meeting criteria, no history ventricular arrhythmias were included. All participants examined by conventional 2D echocardiography TDI...
The randomized clinical trial ESO-SPARE investigates if oesophagus-sparing radiotherapy (RT) can reduce dysphagia in patients with metastatic spinal cord compression (MSCC). Patient-reported outcome (PRO) is the only follow-up measure. Due to fragile patient population, low respondent compliance was anticipated. We performed a planned interim analysis of dosimetry and compliance, ensure that protocol requirements were met.Patients >18 years referred for cervical/thoracic MSCC 1-10 fractions...