A5058708542- Head and Neck Cancer Studies
- Lung Cancer Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Dysphagia Assessment and Management
- Advances in Oncology and Radiotherapy
- Radiomics and Machine Learning in Medical Imaging
- Tracheal and airway disorders
- Medical Imaging and Pathology Studies
- Esophageal Cancer Research and Treatment
- Head and Neck Surgical Oncology
- Cervical Cancer and HPV Research
- Esophageal and GI Pathology
- Heart Failure Treatment and Management
- Effects of Radiation Exposure
- Cardiac, Anesthesia and Surgical Outcomes
- Thyroid Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Radiation Dose and Imaging
- Sexual Differentiation and Disorders
- Blood Pressure and Hypertension Studies
- Cancer-related gene regulation
- Colorectal and Anal Carcinomas
- Management of metastatic bone disease
- Prostate Cancer Treatment and Research
University of Ulster
2014-2023
Belfast City Hospital
2014-2023
The Northern Ireland Cancer Centre
2018-2023
Royal Marsden NHS Foundation Trust
2016-2021
Belfast Health and Social Care Trust
2014-2019
Royal Marsden Hospital
2016
Queen's University Belfast
2004
<h2>Summary</h2><h3>Background</h3> Most newly diagnosed oropharyngeal and hypopharyngeal cancers are treated with chemoradiotherapy curative intent but at the consequence of adverse effects on quality life. We aimed to investigate if dysphagia-optimised intensity-modulated radiotherapy (DO-IMRT) reduced radiation dose dysphagia aspiration related structures improved swallowing function compared standard IMRT. <h3>Methods</h3> DARS was a parallel-group, phase 3, multicentre, randomised,...
Persistent dysphagia following primary chemoradiation (CRT) for head and neck cancers can have a devastating impact on patients' quality of life. Single arm studies shown that the dosimetric sparing critical swallowing structures such as pharyngeal constrictor muscle supraglottic larynx translate to better functional outcomes. However, there are no current randomised confirm benefits swallow strategies. The aim Dysphagia/Aspiration at risk (DARS) trial is determine whether reducing dose...
TNM8 staging for oropharyngeal squamous cell carcinomas (OPSCC) surrogates p16 immunohistochemistry HPV testing. Patients with p16+ OPSCC may lack aetiology. Here, we evaluate the suitability of guiding prognosis in such patients.
Patients treated with radiotherapy for head and neck (H&N) cancer often experience anatomical changes. The potential compromises to Planning Target Volume (PTV) coverage or Organ at Risk (OAR) sparing has prompted the use of adaptive (ART) these patients. However, implementation ART is time resource intensive. This study seeks define a clinical trigger H&N re-plans based on spinal cord safety using kV Cone-Beam Computed Tomography (CBCT) verification imaging, in order best balance benefit...
To determine the clinical outcomes of an intensity-modulated radiotherapy technique for total mucosal irradiation (TM-IMRT) in patients with head and neck carcinoma unknown primary (HNCUP).A single-centre prospective phase II trial design was used two sequential studies to evaluate TM-IMRT HNCUP. Patients were investigated tumour site using examination under anaesthetic biopsies, computed tomography ± magnetic resonance imaging (MRI) or 18-fluorodeoxyglucose positron emission...
6508 Background: Most newly diagnosed oro- & hypopharngeal cancers (OPC, HPC) are treated with (chemo)RT curative intent but at the consequence of adverse effects on quality life. CRUK/14/014 investigated if using Do-IMRT to reduce RT dose dysphagia/aspiration related structures (DARS) improved swallowing function compared S-IMRT. Methods: Patients T1-4, N0-3, M0 OPC/HPC were randomised 1:1 S-IMRT (65 Gray (Gy)/30 fractions (f) primary nodal tumour; 54Gy/30f remaining pharyngeal subsite...
Determination of human papillomavirus (HPV) status has become clinically relevant for patient stratification under UICC TNM8 staging. Within the United Kingdom, a combination p16 IHC and HPV DNA-ISH is recommended classifying status. This study will assess series applicable second-line molecular tests to run in with optimally determine
This study aimed to assess the impact of margin applied clinical target volume, create planning on plan quality a novel dysphagia-optimised intensity modulated radiotherapy technique developed within head and neck cancer multicentre randomised controlled trial. Protocol compliant plans were used for single benchmark case.Larger margins associated with higher doses adjacent organs at risk, particularly inferior pharyngeal constrictor muscle, but coincided some improved low dose coverage. A 3...
MCnorm and MCopt have a value of GTV D50 Dmean comparable to the RT plan higher than MCrecalc plan.At same time, plans could not always be accepted referring OARs dose constraints respect target conformity (see Fig. 1).Results are reported in Table 1. Conclusion:Lower variation parameters compared with PTV, when both treatment evaluated, suggests that should used for normalization reporting instead PTV.According van der Voort Zyp et al. (2010, [2]), different prescription adopted, depending...
6065 Background: Most newly diagnosed oro- & hypopharngeal cancers (OPC, HPC) are treated with (chemo)RT curative intent but at the consequence of adverse effects on quality life. We investigated if using DO-IMRT to reduce RT dose dysphagia/aspiration related structures (DARS) improved swallowing function compared S-IMRT. Methods: Patients T1-4, N0-3, M0 OPC/HPC were randomised 1:1 S-IMRT (65 Gray (Gy)/30 fractions (f) primary nodal tumour; 54Gy/30f remaining pharyngeal subsite areas...