A5017624919- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Alzheimer's disease research and treatments
- Cholinesterase and Neurodegenerative Diseases
- Receptor Mechanisms and Signaling
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Biochemical effects in animals
- Eicosanoids and Hypertension Pharmacology
- Olfactory and Sensory Function Studies
- Neuropeptides and Animal Physiology
- Memory and Neural Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Heart Rate Variability and Autonomic Control
- Biochemical Acid Research Studies
- Treatment of Major Depression
- Trace Elements in Health
- Cardiac Health and Mental Health
- Plant Disease Resistance and Genetics
- Inflammatory mediators and NSAID effects
- Electron Spin Resonance Studies
- Electrochemical Analysis and Applications
- Neuroendocrine regulation and behavior
- Coenzyme Q10 studies and effects
- Genomics and Phylogenetic Studies
John Innes Centre
2020-2024
Norwich Research Park
2020-2024
Royal Veterinary College
2024
Virginia Commonwealth University
2022-2023
SOAS University of London
2022
University of London
2022
Oxford Brookes University
2017-2018
Research Complex at Harwell
2017
Laboratoire de Biogenèse Membranaire
2017
Université de Bordeaux
2017
The formation of thiobarbituric acid-reactive products was measured as an index peroxidation by oxygen free radicals in homogenates frontal cortex and cerebellum from brains taken at autopsy verified histologically being Alzheimer's (n = 6) or normal 6). Compared with controls, basal is significantly higher cortex, this difference also evident the presence exogenous iron. Peroxidation levels total glutathione, RNA, DNA do not differ between brain controls. Iron-induced reduced lazaroid...
Abstract With >7000 species the order of rust fungi has a disproportionately large impact on agriculture, horticulture, forestry and foreign ecosystems. The infectious spores are typically dikaryotic, feature unique to in which two haploid nuclei reside same cell. A key example is Phakopsora pachyrhizi , causal agent Asian soybean disease, one world’s most economically damaging agricultural diseases. Despite P. ’s impact, exceptional size complexity its genome prevented generation an...
Abstract Bacterial extracellular vesicles (BEVs) contribute to stress responses, quorum sensing, biofilm formation and interspecies interkingdom communication. However, the factors that regulate their release heterogeneity are not well understood. We set out investigate these in common gut commensal Bacteroides thetaiotaomicron by studying BEV throughout growth cycle. Utilising a range of methods, we demonstrate released at different stages have significantly composition, with early enriched...
As part of an ongoing investigation the role oxygen free radicals in Alzheimer's disease (AD), formation peroxidation products, activities radical defense enzymes, and level total iron were determined autopsy brain tissue from donors with AD age‐matched non‐demented donors. Calcium uptake was also investigated mitochondria harvested fibroblasts grown culture skin samples taken Compared to controls, homogenates frontal cortex produced elevated levels products this difference amplified a...
Abstract Neuroanatomical studies suggest that neuronal atrophy and destruction occur over the course of many years in neurodegenerative conditions such as schizophrenia Alzheimer's disease. In schizophrenia, early intervention with atypical neuroleptics olanzapine has been shown to prevent development some more serious debilitating symptoms patients. The mechanisms whereby slows or prevents symptom progression remain unclear. A previous study found increased mRNA for copper/zinc isoform...
A significant increase in shock-induced aggression occurs the rat 4 days after an intraventricular injection of 90 micrograms 6-hydroxydopa. Both fluorescent histology and biochemical assay demonstrate that brain norepinephrine is reduced by 6-hydroxydopa, while dopamine remains unaltered. This suggests one form aggressive behavior (shock-induced aggression) modulated through a central noradrenergic system.
Abstract NRCs are essential helper NLR (nucleotide-binding domain and leucine-rich repeat) proteins that execute the immune response triggered by disease resistance proteins, also known as sensor NLRs. The structure of resting state NbNRC2 was recently revealed to be a homodimer. However, sensor-activated has not yet been elucidated. In this study, we used cryo-EM determine NbNRC2, which forms hexameric inflammasome-like resistosome. To confirm functional significance hexamer, mutagenized...
Semicarbazide-sensitive amine oxidase (SSAO) catalyzes the conversion of methylamine to formaldehyde. This enzyme is located on surface cytoplasmic membrane and in cytosol vascular endothelial cells, smooth muscle adipocytes. Increased SSAO activity has been found patients with diabetes mellitus, chronic heart failure, multiple types cerebral infarcts associated obesity. SSAO-mediated deamination may contribute protein deposition, formation plaques, inflammation, thus be involved...
Abstract: The fragment of β‐amyloid comprised amino acids 25–35 induces a rapid, concentration‐dependent increase in cytosolic free calcium levels suspensions PC12 neuronal cells. This action is not altered by pretreatment with the channel blockers nifedipine or cobalt, depleter intracellular stores cyclopiazonic acid, phospholipase C inhibitor neomycin. However, effects on are absent calcium‐free buffer and blocked antioxidant lazaroid U‐83836E vitamin E. β‐Amyloid also neurotoxic produces...
Removal of the main olfactory bulbs in rats has been shown to alter neuronal function brain areas involved emotional regulation and homeostasis. These alterations result maladaptive behavioral patterns elevated plasma corticosterone that are suggestive symptom profile patients with primary unipolar depression. Moreover, endocrine deficits bulbectomized reversed by chronic administration drugs reverse symptoms depression people when given chronically. However, therapeutic improvements seen...
We have demonstrated recently that atypical antipsychotics possess neuroprotective actions in H2O2-mediated and serum-withdrawal models of cell death. In the present study, we compared ability typical to protect against an insult mediated by Abeta(25-35), apoptogenic fragment Alzheimer's disease-related beta-amyloid (Abeta) peptide. Treatment PC12 cultures with Abeta(25-35) did not significantly alter total cellular expression levels Bax, a proapoptotic Bcl-2 family member, or Bcl-XL,...