A5088690109- Circular RNAs in diseases
- Cardiac Fibrosis and Remodeling
- Traditional Chinese Medicine Studies
- Atherosclerosis and Cardiovascular Diseases
- Cytokine Signaling Pathways and Interactions
- MicroRNA in disease regulation
- Computational Drug Discovery Methods
- Drug-Induced Hepatotoxicity and Protection
- Adipokines, Inflammation, and Metabolic Diseases
Beijing University of Chinese Medicine
2022-2024
Traditional Chinese medicine and Western combination (TCM-WMC) increased the complexity of compounds ingested.To develop a method for screening hepatotoxic in TCM-WMC based on chemical structures using artificial intelligence (AI) methods.Drug-induced liver injury (DILI) data was collected from public databases published literatures. The total dataset formed by DILI randomly divided into training set test at ratio 3:1 approximately. Machine learning models SGD (Stochastic Gradient Descent),...
Background MicroRNAs (miRNAs) are endogenous noncoding single-stranded small RNAs. Numerous studies have shown that miRNAs pivotal roles in the occurrence and development of myocardial fibrosis (MF). However, miRNA expression profile rats with MF after infarction (MI) is not well understood. The present study aimed to find potential for post MI. Methods SPF male Sprague-Dawley (SD) rat models acute (AMI) were established by ligating anterior descending branch left coronary artery, while...