A5100664593- Pituitary Gland Disorders and Treatments
- Glioma Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Neurosurgical Procedures and Complications
- Adrenal and Paraganglionic Tumors
- Intracerebral and Subarachnoid Hemorrhage Research
- Meningioma and schwannoma management
- Growth Hormone and Insulin-like Growth Factors
- Cerebrospinal fluid and hydrocephalus
- Heat shock proteins research
- Spinal Cord Injury Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Moyamoya disease diagnosis and treatment
- MicroRNA in disease regulation
- Nerve injury and regeneration
- Ubiquitin and proteasome pathways
- thermodynamics and calorimetric analyses
- Axon Guidance and Neuronal Signaling
- Spinal Hematomas and Complications
- Ferroptosis and cancer prognosis
- Neurological Complications and Syndromes
- Angiogenesis and VEGF in Cancer
- Cerebrovascular and Carotid Artery Diseases
- Glycosylation and Glycoproteins Research
Huazhong University of Science and Technology
2013-2024
Tongji Hospital
2013-2024
Essen University Hospital
2022
University of Duisburg-Essen
2018-2020
Nanfang Hospital
2019
Shandong Provincial Hospital
2000
Background Programmed cell death 10 (PDCD10) plays a crucial role in regulating tumor phenotyping, especially glioblastoma (GBM). Glioma-associated microglia/macrophages (GAMs) pathological microenvironment contribute to GBM progression. We previously found that the infiltration of GAMs was associated with PDCD10 expression patients. The present study aims further explore regulation on GBM. Methods Overexpression human- and murine-GBM cells established by lentiviral transduction. Cell...
Aim: To investigate the predictor of hypothalamic-pituitary-gonadal (HPG) axis recovery in male pituitary adenoma patients with trans-sphenoid extrapseudocapsular microsurgery. Methods: From June 2019 to December 2021, we retrospectively analyzed clinical data gonadal hormone changes and resection degree before after surgery nonfunctioning (NFPA) who underwent microsurgical by pseudocapsule technique same treatment group at Department Neurosurgery, Tongji Hospital. We explored predictors...
Neuroinflammatory processes mediated by microglial activation and subsequent neuronal damage are the hallmarks of traumatic brain injury (TBI). As an inhibitor macrophage‑inducible C‑type lectin (Mincle)/spleen tyrosine kinase (Syk) signaling pathway, BAY61‑3606 (BAY) has previously demonstrated anti‑inflammatory effects on some pathological processes, such as acute kidney injury, suppressing inflammatory macrophage response. In present study, potential BAY phenotype neuroinflammation after...
Alginate capillary hydrogels seeded with differentiated cells can fill the lesion cavity and promote axonal regeneration after grafting into injured spinal cord. Neural stem/progenitor (NSPCs) potentially repair cord; however, effects of alginate (AHs) on NSPCs remain unknown. In this study, we fabricated AHs cross-linked by Ca2+ rat embryonic day 14 NSPCs. Immunocytochemistry electron microscopy show that survive, proliferate differentiate neurons in vitro within capillaries. After...
Invasiveness is a major predictor of surgical outcome and long-term prognosis in patients with pituitary adenomas (PAs). We assessed PA invasiveness via radiological, histological perspectives to establish classification scheme for predicting invasive behavior poor prognosis. retrospectively analyzed 903 who underwent transnasal-transsphenoidal surgery between January 2013 December 2019. Radiological (hazard ratio (HR) 5.11, 95% confidence interval (CI): 3.98–6.57, p < 0.001) (HR 6.40,...
We have previously reported that cell-seeded alginate hydrogels (AHs) with anisotropic capillaries can restore the continuity of spinal cord and support axonal regeneration in a rat model acute partial transection. Whether similar effects be found after transplantation into sites complete chronic transections without additional growth-promoting stimuli has not been investigated. therefore implanted AHs cavity thoracic transection following scar resection (SR) 4 weeks postinjury examined...
Background: Patients with traumatic epidural haematoma, undergoing the prompt and correct treatment, usually have favourable outcomes. However, secondary cerebral infarction may be life-threatening condition, as it is difficult to identified before neurological impairment occurs.Objective: To evaluate clinical data of patients EDH assess potential risk factors for post-operative infarction.Methods: The were collected analysed retrospectively.Results: univariate analysis revealed 10 (the...
Maternal gut microbiota play an important role in the modulation of offspring disease susceptibility and dysbiosis has been proposed as a mechanism through which toxic environmental chemicals exert their adverse impacts on health. The brominated flame retardants polybrominated diphenyl ethers (PBDEs) are developmental toxicants induce dysbiotic offspring. Yet, whether how PBDEs impact maternal remain unclear. Here, we sought to investigate effect 2,2′,4,4′-tetrabromodiphenyl ether (PBDE-47)...
Background Cerebral extracranial-intracranial (EC-IC) revascularization technique (superficial temporal artery-middle cerebral artery (STA-MCA) bypass grafting) has become the preferred surgical method for treatment of Moyamoya disease (MMD). We attempted to completely free two branches superficial without disconnection. Extracranial and intracranial blood flow reconstruction were then modified by selectively performing a direct on one branch patch fusion other STA based vascular diameter...
We previously reported an angiogenic and tumor-suppressor-like function of programmed cell death 10 (PDCD10) in glioblastoma (GBM). However, the underlying mechanism remains to be elucidated. hypothesized that loss PDCD10 activates GBM cells tumor progression via EphB4. To this end, was knocked down U87 T98g by lentiviral mediated shRNA transduction (shPDCD10). phenotype vitro growth a mouse xenograft model were investigated presence or absence treatment with specific EphB4 kinase inhibitor...
BACKGROUND Hydrocephalus secondary to hypertensive intracerebral hemorrhage (HICH) dramatically affects the prognosis. Early enteral nutrition (EN) is beneficial severe HICH patients, but impact of early EN administration on hydrocephalus remains unknown. This study aimed explore predictors for occurrence after HICH, with special focus effect application. MATERIAL AND METHODS We retrospectively analyzed 146 patients who underwent microsurgery between January 2014 and October 2019 in our...
OBJECTIVE The intracranial hematoma volume in patients with traumatic brain injury is a key parameter for the determination of management approach and outcome. Apolipoprotein E ( APOE ) ε4 reported to be risk factor larger volume, which might contribute poor However, whether related progressive hemorrhagic (PHI), common occurrence clinical setting, remains unclear. In this study, authors aimed investigate association between genotype PHI. METHODS This prospective study included cohort 123...
As the pathogenesis of plurihormonal pituitary adenoma (PPA) is unclear and diagnostic criteria are inconsistent, clinicians still find it challenging to diagnose. To analyze relationship between clinical pathological characteristics in PPA.The data patients with 70 PPAs admitted during 2008-2010 2019-2020 were collected analyzed. In particular, hormone examination using cell culture supernatant was performed confirm PPA cases from 2019 2020.PPA accounted for 13% all recorded same period....
We aimed to assess clinical factors associated with tumor recurrence and build a nomogram based on identified risk predict postoperative in patients pituitary adenomas (PAs) who underwent gross-total resection (GTR). A total of 829 PAs achieved GTR at Tongji Hospital between January 2013 December 2018 were included this retrospective study. The median follow-up time was 66.7 months (range: 15.6-106.3 months). Patients randomly divided into training (n = 553) or validation 276) cohorts. range...