A5101879435- earthquake and tectonic studies
- High-pressure geophysics and materials
- Geological and Geochemical Analysis
- Seismic Waves and Analysis
- Geological and Geophysical Studies
- Seismic Imaging and Inversion Techniques
- Seismology and Earthquake Studies
- Clinical Nutrition and Gastroenterology
- Autophagy in Disease and Therapy
- Mitochondrial Function and Pathology
- Earthquake Detection and Analysis
- Landslides and related hazards
- Cardiovascular Function and Risk Factors
- Birth, Development, and Health
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Fatty Acid Research and Health
- Cancer-related molecular mechanisms research
- Pediatric health and respiratory diseases
- Neonatal Respiratory Health Research
- Exercise and Physiological Responses
- Macrophage Migration Inhibitory Factor
- Burn Injury Management and Outcomes
- Diabetes Treatment and Management
- Functional Brain Connectivity Studies
Zhujiang Hospital
2016-2024
Southern Medical University
2016-2024
Sun Yat-sen University
2020-2024
Second Hospital of Anhui Medical University
2024
Anhui Medical University
2006-2024
Soochow University
2024
Second Affiliated Hospital of Soochow University
2024
Third Affiliated Hospital of Sun Yat-sen University
2023-2024
University of Science and Technology of China
2024
Nanfang Hospital
2021-2023
Mitophagy preserves microvascular structure and function during myocardial ischemia/reperfusion (I/R) injury. Empagliflozin, an anti-diabetes drug, may also protect mitochondria. We explored whether empagliflozin could reduce cardiac I/R injury by enhancing mitophagy. In mice, induced luminal stenosis, microvessel wall damage, erythrocyte accumulation perfusion defects in the microcirculation. Additionally, triggered endothelial hyperpermeability neutrophil infiltration, which upregulated...
Ru 1 –Mo 2 C, a novel dual-site synergistic catalyst, demonstrated exceptional performance for the alkaline hydrogen evolution reaction (HER) through reversible spillover mechanism.
Osteoarthritis (OA) is a common degenerative joint disorder, which involves articular cartilage degeneration as well inflammatory reactions.The recent studies have identified microRNA (miRNA) one of the epigenetic mechanisms for regulation gene expression.Here we aim to reveal role miRNA in expression chondrocytes and its significance OA pathogenesis.In present study, profiling was performed using normal healthy tissues.As compared their levels cells tissues, miR-27a found be upregulated...
Abstract Precise coordination of cell growth, proliferation and differentiation is essential for the development multicellular organisms. Here, we report that although mechanistic target rapamycin complex 1 (mTORC1) activity required chondrocyte growth proliferation, its inactivation differentiation. Hyperactivation mTORC1 via TSC1 gene deletion in chondrocytes causes uncoupling normal programme within plate, resulting uncontrolled blockage chondrodysplasia mice. Rapamycin promotes restores...
The Tonga double seismic zone depth and distribution are controlled by slab temperature, which affects dehydration reactions.
Proliferation is one of the significant hallmarks gallbladder cancer, which a relatively rare but fatal malignance.Aim this study was to examine biological impact and molecular mechanism candidate hub-gene on proliferation tumorigenesis cancer.We analyzed differentially expressed genes correlation between these with MKI67, showed that KIF11 major upregulated regulators in cancer (GBC).The Gene Ontology, Sets Enrichment Analysis KEGG Pathway analysis indicated may promote GBC cell through...
An L-configured, three-component short period seismic array was deployed on the Ross Ice Shelf, Antarctica during November 2014. Polarization analysis of ambient noise data from these stations shows linearly polarized waves for frequency bands between 0.2 and 2 Hz. A spectral peak at about 1.6 Hz is interpreted as resonance water column used to estimate layer thickness below ice shelf. The band 4 18 dominated by Rayleigh Love propagating north that, based daily temporal variations, we...
Schistosomiasis is a parasitic helminth disease that can cause severe inflammatory pathology, leading to organ damage, in humans. During schistosomal infection, the eggs are trapped host liver, and products derived from induce polarized Th2 cell response, resulting granuloma formation eventually fibrosis. Previous studies indicated nucleotide-binding oligomerization domain-, leucine-rich repeat-, pyrin domain-containing protein 3 (NLRP3) inflammasome involved schistosomiasis-associated liver...
<title>Abstract</title> <bold>Background: </bold>Sodium-glucose co-transporter 2 (SGLT2) inhibitors exhibit significant cardiovascular protective effects in patients with acute myocardial infarction (AMI) complicated type diabetes mellitus (T2DM), mainly through enhancing cardiac function and reducing malignant arrhythmias. However, evidence supporting their efficacy non-diabetic AMI is limited. Moreover, the relationship between these benefits improvements autonomic left ventricular...
Liraglutide, a modified form of glucagon-like peptide-1 (GLP-1), has been found to improve beta cell function in type 2 diabetes (T2DM). However, the effect liraglutide on under lipotoxic stress and underlying molecular mechanisms remain unclear. In present study, we investigated role PI3K/Akt/FoxO1 signaling liraglutide-involved protection high free fatty acids (FFAs) condition. The apoptosis, proliferation, insulin secretion capability MIN6 cells islets from C57BL/6J mice were evaluated...
Cardiorenal syndrome type-3 (CRS-3) is an abrupt worsening of cardiac function secondary to acute kidney injury. Mitochondrial dysfunction a key pathological mechanism CRS-3, and empagliflozin can improve mitochondrial biology by promoting mitophagy. Here, we assessed the effects on quality surveillance in mouse model CRS-3. Cardiomyocyte-specific FUNDC1-knockout (FUNDC1CKO) mice were subjected CRS-3 prior assessment homeostasis presence or absence empagliflozin. exhibited lower heart...
Abstract Seismic signals captured by ocean bottom pressure sensors, which are designed to record tsunami waves, largely ignored. In this paper, we derive a simple theoretical solution of the as function prescribed seafloor motion. All assumptions clearly stated and analyzed. The is checked comparing displacement from three M 7+ earthquakes, recorded seismometers gauges located off Japanese coast. We then show two applications. First, using data an seismometer, amplitude associated gauge...
Numerous mitochondrial abnormalities are reported to result from excessive inflammation during endotoxemia.Prohibitin 2 (PHB2) and phosphoglycerate mutase 5 (Pgam5) have been associated with altered homeostasis in several cardiovascular diseases; however, their role endotoxemia-related myocardial dysfunction has not explored.Our experiments were aimed evaluate the potential contribution of Pgam5 PHB2 endotoxemia-induced cardiomyocytes, a focus on two endogenous protective programs that...
Abstract Earthquakes near oceanic trenches are important for studying incoming plate bending and updip thrust zone seismogenesis, yet poorly constrained using seismographs on land. We use an ocean bottom seismograph (OBS) deployment spanning both the Pacific Plate forearc to study seismicity Mariana Trench. The yearlong in 2012–2013 consisted of 20 broadband OBSs 5 suspended hydrophones, with additional 59 short period hydrophones recording 1 month. locate 1,692 earthquakes a nonlinear...
Abstract Horizontal records of ocean-bottom seismographs are usually noisy at low frequencies (&lt; 0.1 Hz). The noise source is believed to be associated with currents that may tilt the instrument. Currently horizontal mainly used remove coherent in vertical records, and there has been little literature quantitatively discusses mechanism characteristics low-frequency noise. In this article, we analyze situ measurements by rotating data horizontally evaluating coherency between different...
Abstract The 9 November 2009 M w 7.3 Fiji deep earthquake is the largest event in a region west of Tonga slab defined by scattered seismicity and velocity anomalies. main shock rupture was compact, but aftershocks were distributed along linear feature at distances up to 126 km. some background define sharp northern boundary zone outboard earthquakes, extending westward toward Vitiaz cluster. lineament geometrically similar tectonic reconstructions relict subduction 8–10 Ma, suggesting...