A5081101436- Effects and risks of endocrine disrupting chemicals
- Birth, Development, and Health
- Contact Dermatitis and Allergies
- Skin Protection and Aging
- Advancements in Transdermal Drug Delivery
- Heavy Metal Exposure and Toxicity
- Epigenetics and DNA Methylation
- Trace Elements in Health
- Pharmaceutical studies and practices
- Mitochondrial Function and Pathology
- Biochemical Analysis and Sensing Techniques
- Cancer-related Molecular Pathways
- Animal testing and alternatives
- Toxic Organic Pollutants Impact
- Dermatology and Skin Diseases
- Polyamine Metabolism and Applications
- Olfactory and Sensory Function Studies
- Science Education and Perceptions
- melanin and skin pigmentation
- Cancer, Hypoxia, and Metabolism
- Diet and metabolism studies
- Indoor Air Quality and Microbial Exposure
- Pregnancy and Medication Impact
- Estrogen and related hormone effects
- Microplastics and Plastic Pollution
Shanghai Innovative Research Center of Traditional Chinese Medicine
2025
Huazhong University of Science and Technology
2013-2018
Ministry of Ecology and Environment
2013-2018
Rutgers Cancer Institute of New Jersey
2018
Rutgers, The State University of New Jersey
2018
In-Q-Tel
2016
Environmental Health
2016
Exposure to bisphenol A (BPA), a monomer widely used manufacture polycarbonate plastics, has been reported be associated with abnormalities of liver function and hepatic damage. However, the molecular mechanism under pathogenesis injury is unclear. In this study, effect perinatal exposure BPA at reference dose 50 µg/kg/day on apoptotic index in rat offspring was investigated. Increased levels ALT enhanced cell apoptosis were observed 15 21 weeks, significantly increased activity caspase-3...
Developmental exposure to bisphenol A (BPA) has been linked impaired glucose homeostasis and pancreatic function in adulthood, which hypothesized result from the disruption of β-cell development at early life.
Skin aging is one of the most abundant aging-related disorders that can be accelerated by excessive exposure to ultraviolet irradiation. Topically applied fermented skincare ingredients have gained mounting attentions due their high concentration various skin nourishing nutrients and bioactive components low irritation potency.
ABSTRACT Bisphenol A (BPA) exposure has been reported to be epidemiologically associated with heart disease. As mitochondria play an important role in the early development of and pathogenesis disease, current study investigated possibility cardiac mitochondrial injury neonatal rat prenatally exposed BPA. Pregnant Wistar rats were BPA 50 µg kg –1 day or corn oil 1 ml by oral gavage throughout gestation. Heart samples from pups on postnatal isolated for analysis. Ultrastructure results showed...
Developmental exposure to bisphenol A (BPA) has been indicated pose long-lasting effects on brain development and behaviors in adulthood.
The present study aimed to reveal the amount per application of facial sheet masks and its influencing factors in Chinese population form base for an accurate exposure assessment. A total 175 healthy subjects aged 18 years or older were recruited divided into two subgroups: one group 35 asked apply same mask 5, 10, 15, 20, 25, 30 min respectively, other 140 instructed four types presented market 15 min. Furthermore, phenoxyethanol methylparaben measured reflect actual chemicals. sharp...
Pregnant women are a unique group undergoing profound structural modifications in uterus, breast, adipose tissue,<italic>etc.</italic>
Increasing evidence indicates that bisphenol A (BPA), a widely manufactured environmental pollutant, can induce changes in DNA methylation paatterns, which is potential mechanism linking this exposure to disease development. We investigated the influence of developmental BPA on pancreatic patterns and whether maternal folate supplementation modify epigenetic status impairment induced by BPA. Our results showed dietary rats exposed counteracted observed BPA-induced impairments offspring,...
The present study aims to investigate the current trends in replacing conventional preservatives with multifunctional ingredients antimicrobial properties for preservation of cosmetics infants or sensitive population, decrease their potential contact dermatitis. We first reviewed labels purchased from Chinese market and properties, which actual contents were further quantified by chromatographic methods. identified 7 traditional (phenoxyethanol, benzoic acid (salts), methylparaben, benzyl...
Melanin content significantly influences the skin-lightening effects of active ingredients, with inhibition melanin synthesis contributing to effects. This study evaluates novel cyclopeptide CHP-9 as a safe and potent human tyrosinase inhibitor. showed significant rate approximately 28.57% at 1% concentration. The formation assay, upon exposure alone, resulted in reduction cellular from 30.90±1.13 μg/mL 23.51±1.14 μg/mL. Additionally, silico molecular docking experiments were conducted...
Abstract Metformin has recently gained attention as an anti-cancer drug and/or a chemoprevention agent because of its roles in inhibiting mTOR, lowering hyperinsulinemia, modulating inflammatory responses, and selectively killing cancer stem cells. However, the key underlying molecular mechanisms for inhibitory effects metformin on pancreatic progression remain largely unknown. RET (REarranged during Transfection), single-pass transmembrane receptor tyrosine kinase ligand, glial cell-derived...