A5086908914- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Virology and Viral Diseases
- Respiratory viral infections research
- Diabetes Management and Research
- Personality Traits and Psychology
- Social and Intergroup Psychology
- Liver Disease Diagnosis and Treatment
- HIV/AIDS drug development and treatment
- Immune Response and Inflammation
- Viral Infections and Vectors
- Sepsis Diagnosis and Treatment
- Rabies epidemiology and control
- Viral Infections and Immunology Research
- Parvovirus B19 Infection Studies
- Virus-based gene therapy research
- Neonatal Respiratory Health Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Congenital Diaphragmatic Hernia Studies
- Adipose Tissue and Metabolism
- Pelvic and Acetabular Injuries
- Evolutionary Psychology and Human Behavior
- Influenza Virus Research Studies
- Eosinophilic Esophagitis
The University of Texas Health Science Center at San Antonio
2014-2024
La Jolla Alcohol Research
1978-2024
Morristown Medical Center
2009-2023
Texas Diabetes Institute
2013-2023
Urology San Antonio
2018-2023
University Health System
2018-2023
Kuwait Petroleum Corporation (Kuwait)
2022
The University of Texas Health Science Center at Houston
2020
University of Alabama
2012-2019
Galveston College
2019
Increased intramyocellular lipid concentrations are thought to play a role in insulin resistance, but the precise nature of species that produce resistance human muscle unknown. Ceramides, either generated via activation sphingomyelinase or produced by de novo synthesis, induce cultured cells inhibitory effects on signaling. The present study was undertaken determine whether ceramides other sphingolipids increased from obese insulin-resistant subjects and assess ceramide plays Akt muscle....
To test our hypothesis that initiating therapy with a combination of agents known to improve insulin secretion and sensitivity in subjects new-onset diabetes would produce greater, more durable reduction glycated haemoglobin (HbA1c) levels, while avoiding hypoglycaemia weight gain, compared sequential addition lower plasma glucose but do not correct established pathophysiological abnormalities.Drug-naïve, recently diagnosed type 2 mellitus (T2DM) were randomized an open-fashion design...
The number of young farmers has decreased over recent decades in several developed countries such as the United States and European countries. A strategy adopted by Union to address resulting age imbalance is Young Farmer Payment which provides an additional payment on top average basic introduced last Common Agricultural Policy reform. objective this study determine, means a behavioural approach, how influenced incentives stay farm. Using endogenous succession cycle model structural...
Abstract Objective To examine whether lowering plasma glucose concentration with the sodium-glucose transporter-2 inhibitor empagliflozin improves β-cell function in patients type 2 diabetes mellitus (T2DM). Methods Patients T2DM (N = 15) received (25 mg/d) for weeks. β-Cell was measured a nine-step hyperglycemic clamp (each step, 40 mg/dL) before and at 48 hours 14 days after initiating empagliflozin. Results Glucosuria recorded on 1 [mean ± standard error of mean (SEM), 101 10 g 117 11 g,...
The present report deals with a hitherto undescribed form of epidemic pulmonary disease occurring in newborn infants. Its peculiar symptomatology and pathology, as well its character, clearly indicate the virus nature etiology. Characteristic cytoplasmic inclusion bodies were found bronchial epithelium all fatal cases. An increasing number reports on subject atypical pneumonia or pneumonitis man has occurred literature during recent years.<sup>1</sup>That Goodpasture his...
Synchronized cardioversion is generally accepted as safe for the treatment of ventricular tachycardia and atrial fibrillation when shocks are synchronized to R wave delivered transthoracically. However, others have shown that during attempted transvenous rapid tachycardia, (VF) may be induced. It was our objective evaluate conditions (short irregular cycle lengths [CL]) under which VF might induced electrical conversion with electrodes.In 16 sheep (weight, 62 +/- 7.8 kg), defibrillation...
To examine metabolic factors that influence ketone production after sodium-glucose cotransport inhibitor (SGLT2) administration.Fasting plasma glucose (FPG), insulin, glucagon, free fatty acid and concentrations were measured in 15 type 2 diabetes mellitus (T2DM) 16 non-diabetic subjects before at day 1 14 treatment with empagliflozin.Empagliflozin caused a 38 mg/dL reduction FPG concentration T2DM patients. However, it only small but significant (7 mg/dL) the impaired fasting (IFG) did not...
Cells which are infected with measles virus have been known for some time to contain inclusion material that is distinguishable from normal cellular components by application of traditional staining methods and observation in the light microscope. The fine structure contained HeLa cells Edmonston strain has examined electron Two steps found necessary this study: (1) recognition phase-contrast microscopy living cell bodies defined as when classically stained; (2) microscope inclusion-body had...
Normoglycemic subjects with a strong family history of type 2 diabetes are insulin resistant, but the mechanism resistance in skeletal muscle such individuals is unknown. The present study was undertaken to determine whether abnormalities insulin-signaling events normoglycemic, nonobese diabetes. Hyperinsulinemic-euglycemic clamps percutaneous biopsies were performed eight normoglycemic relatives diabetic patients (FH+) and control who had no (FH−), each group matched for age, sex, body...
To assess glucose-lowering mechanisms of sitagliptin (S), metformin (M), and the two combined (M+S).We randomized 16 patients with type 2 diabetes mellitus (T2DM) to four 6-week treatments placebo (P), M, S, M+S. After each period, subjects received a 6-h meal tolerance test (MTT) [(14)C]glucose calculate glucose kinetics. Fasting plasma (FPG), fasting insulin, C-peptide (insulin secretory rate [ISR]), glucagon, bioactive glucagon-like peptide (GLP-1) gastrointestinal insulinotropic (GIP)...
The decrement in plasma glucose concentration with SGLT2 inhibitors (SGLT2i) is blunted by a rise endogenous production (EGP). We investigated the ability of incretin treatment to offset EGP increase. Subjects type 2 diabetes (n = 36) were randomized 1) canagliflozin (CANA), 2) liraglutide (LIRA), or 3) CANA plus LIRA (CANA/LIRA). was measured [3-3H]glucose without drugs for 360 min. In pretreatment studies, comparable and decreased (2.2 ± 0.1 1.7 0.2 mg/kg ⋅ min) during 300- 360-min period...
Humans become increasingly fragile as they age. We show that something similar may happen to states, although for the risk of termination levels off grow older, allowing some persist millennia. Proximate causes their ...How states and great powers rise fall is an intriguing enigma human history. Are there any patterns? Do polities more vulnerable over time age? analyze longevity in hundreds premodern using survival analysis help ...
To compare the long-term efficacy of initiating therapy with metformin/pioglitazone/exenatide in patients new-onset type 2 diabetes mellitus (T2DM) versus sequential addition metformin followed by glipizide and insulin.Drug-naive (N = 318) T2DM were randomly assigned to receive for 3 years either 1) combination metformin, pioglitazone, exenatide (triple therapy) or 2) insulin (conventional maintain HbA1c at <6.5% (48 mmol/mol). Insulin sensitivity β-cell function measured baseline years. The...
Abstract Aim To compare the efficacy of triple therapy (metformin/exenatide/pioglitazone) versus stepwise conventional (metformin → glipizide glargine insulin) on liver fat content and hepatic fibrosis in newly diagnosed, drug‐naïve patients with type 2 diabetes. Methods Sixty‐eight completed 6‐year follow‐up had an end‐of‐study (EOS) FibroScan to provide measures steatosis (controlled attenuation parameter [CAP] dB/m) (liver stiffness measurement [LSM] kPa); 59 magnetic resonance...
OBJECTIVE To examine the effect of empagliflozin on liver fat content in individuals with and without type 2 diabetes (T2D) relationship between decrease other metabolic actions empagliflozin. RESEARCH DESIGN AND METHODS Thirty T2D 27 were randomly assigned to receive double-blind fashion or matching placebo (2:1 ratio) for 12 weeks. Participants underwent 75-g oral glucose tolerance testing measurement MRS before therapy at study end. Hepatic production start was measured 3-3H-glucose....