A5015913955- Pomegranate: compositions and health benefits
- Bioactive Compounds in Plants
- Plant biochemistry and biosynthesis
- NF-κB Signaling Pathways
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Virus-based gene therapy research
- Magnolia and Illicium research
- Cynara cardunculus studies
- Cytokine Signaling Pathways and Interactions
- Immune Response and Inflammation
- RNA Interference and Gene Delivery
- Hops Chemistry and Applications
- Morinda citrifolia extract uses
- Plant Gene Expression Analysis
- Pharmacological Effects of Natural Compounds
- Mesenchymal stem cell research
- Advanced Glycation End Products research
- Photosynthetic Processes and Mechanisms
- Irrigation Practices and Water Management
- Immune Cell Function and Interaction
Shaanxi Normal University
2019-2024
Daping Hospital
2024
Army Medical University
2024
Ministry of Education Science and Technology
2019-2020
Jiangsu University
2012
Urolithin A (URA) is an intestinal microbiota metabolic product from ellagitannin-containing foods with multiple biological activities. However, its role in autoimmune diseases largely unknown. Here, for first time, we demonstrate the therapeutic effect of URA experimental encephalomyelitis (EAE) animal model.Therapeutic was evaluated via active and passive EAE model vivo. The function on bone marrow-derived dendritic cells (BM-DCs), T cells, microglia were tested vitro.Oral (25 mg/kg/d)...
Multiple sclerosis (MS) is a CNS autoimmune disease characterized by demyelination and inflammatory infiltration with high disability rate. Increasing evidence has demonstrated the importance of gut microbiota as an environmental risk factor in MS its animal model experimental encephalomyelitis (EAE). Diet main determinant composition function, which greatly affects shaping microbial structure. Pomegranate peel, waste product production juice, rich health-promoting compounds. However,...
High-mobility group box 1 (HMGB1) is a non-histone nuclear protein that released extracellulary and has been implicated in autoimmune disease. Toll-like receptor 2 (TLR2) signalling thought to be essential for the inflammatory response immune disorders. In recent studies, enhanced HMGB1 TLR2 expressions have found rheumatoid arthritis (RA), respectively. The aim of this study explore whether stimulation can up-regulate expression on CD14(+) monocytes from patients with RA clarify subsequent...
Natural compounds are a rich source of effective candidate drugs for the treatment neurological disorders.
Eriodictyol (EDT), a natural flavonoid abundant in citrus fruits and peanuts, alleviates clinical signs of EAE by suppressing RORγt-Regulated Th17 cell differentiation.
To elucidate the underlying mechanism by which proliferation and migration abilities of human umbilical cord mesenchymal stem cells (hUC-MSCs) determine their therapeutic efficacy in rheumatoid arthritis treatment.
Immunosuppressants currently approved for the treatment of autoimmune diseases and organ transplant rejection present diverse adverse effects that impair life quality patients. Therefore, development novel immunomodulators with high efficiency low toxicity is essential. Ellagic acid (EA), a natural polyphenol compound widely distributed in berries, metabolically transformed by gut microbiome to exert systemic health benefits. Here, we identified intraperitoneal administration EA no...