A5100457134- Shoulder and Clavicle Injuries
- Liver Disease Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Pelvic and Acetabular Injuries
- Forensic Anthropology and Bioarchaeology Studies
- Hepatitis B Virus Studies
- Trauma Management and Diagnosis
- Heme Oxygenase-1 and Carbon Monoxide
- Shoulder Injury and Treatment
- Peroxisome Proliferator-Activated Receptors
- Cervical Cancer and HPV Research
- Acute Ischemic Stroke Management
- Sepsis Diagnosis and Treatment
- Bone fractures and treatments
- Sirtuins and Resveratrol in Medicine
- Soft tissue tumor case studies
- Preterm Birth and Chorioamnionitis
- Oral and Maxillofacial Pathology
- Plant biochemistry and biosynthesis
- Antibiotic Use and Resistance
- Ectopic Pregnancy Diagnosis and Management
- Immunotherapy and Immune Responses
- Electrospun Nanofibers in Biomedical Applications
- Photodynamic Therapy Research Studies
- Streptococcal Infections and Treatments
Shanxi Medical University
2024
Institute of Forensic Science
2013-2024
Beijing University of Chinese Medicine
2018-2024
Hangzhou First People's Hospital
2024
Westlake University
2024
Shanghai Innovative Research Center of Traditional Chinese Medicine
2023
Beijing Tsinghua Chang Gung Hospital
2023
Ministry of Agriculture and Rural Affairs
2023
Nanjing Agricultural University
2023
Zhejiang University
2023
Hepatitis B virus (HBV) causes acute and chronic hepatitis hepatocellular carcinoma. Small interfering RNA (siRNA) lamivudine have been shown to anti-HBV effects through different mechanisms. However, assessment of the genome-wide siRNA on HBV-producing cell lines has not reported, which may provide a clue interrogate HBV-cell interaction evaluate siRNA's side effect as potential drug. In present study, we designed seven siRNAs based conserved HBV sequences tested their expression genes...
Objective Recent evidence indicates a crucial role of the immunoinhibitory receptor programmed death-1 (PD-1) in enforcing T-cell dysfunction during chronic viral infection and cancer. We assessed impact circulating soluble PD-1 (sPD-1) levels on long-term dynamics hepatitis B virus (HBV) load hepatocellular carcinoma (HCC) risk. Methods In case-cohort study longitudinal analysis within cohort 2903 men chronically infected with HBV, followed up from baseline (1989–1992) through 2010, we...
The accumulation of carotenoids, such as xanthophylls, lycopene, and carotenes, is responsible for the color carrot (Daucus carota subsp. sativus) fleshy roots. potential role DcLCYE, encoding a lycopene ε-cyclase associated with root color, was investigated using cultivars orange red expression DcLCYE in varieties significantly lower than that carrots at mature stage. Furthermore, accumulated larger amounts levels α-carotene. Sequence comparison prokaryotic analysis revealed amino acid...
Background Chinese populations have been reported higher incidence of all strokes and intracerebral hemorrhage. However, few large-scale studies evaluated changes stroke epidemiology in the 21st century. Methods We explored rates first-ever strokes, subtypes, 1-month case fatality by using data from Taiwan National Health Insurance Research Database since 2004. Also, we investigated sex differences stroke. Time-trend analysis was performed for subtypes both sexes. Results The age-adjusted...
Eur J Clin Invest 2011; 41 (3): 299–307 Background Myolysis of atrial cardiomyocytes occurs in patients with severe mitral and tricuspid regurgitation. This morphological remodelling may involve autophagy. Methods study comprised 20 (10 long-standing persistent fibrillation 10 sinus rhythm) Atrial appendageal tissues were obtained during surgery. The appearance autophagosomes (LC3B) myocytes can reflect autophagy induction. Complement 9 is used as a reliable marker oncosis. Results In the...
Nicotinamide N-methyltransferase (NNMT) catalyzes the methylation of nicotinamide. Our previous works indicate that NNMT is involved in body mass index and energy metabolism, recently association between a SNP (rs694539) variety cardiovascular diseases was reported. At present, more than 200 single nucleotide polymorphisms (SNPs) have been identified databases human genome projects; however, rs694539 variation hyperlipidemia has not reported yet, whether there are any SNPs significantly...
Nonalcoholic fatty liver disease (NAFLD) is a chronic characterized by the accumulation of triglycerides and associated with obesity, hyperlipidemia insulin resistance. Currently, there no therapy for NAFLD. Emerging evidences suggest that inhibition X receptor (LXR) activity may be potential hepatic steatosis. Here, we identified sophoricoside selective antagonist LXRβ. Sophoricoside protected against obesity glucose tolerance, inhibited lipid in high‐fat diet‐induced (DIO) mice methionine...
The incidence of stroke has increased significantly in recent years. Post-stroke hemiplegia is a common complication with long-term negative consequences. Several studies have suggested that acupuncture could be an effective intervention for the rehabilitation post-stroke hemiplegia. Intradermal needling kind which widely used clinical settings. This study attempts to investigate biomechanical effects intradermal needle recovery.This proposed single-centered, prospective, single-blinded...
Abstract Liver cirrhosis is a critical state in the natural course of hepatocellular carcinoma (HCC). We sought to investigate potential in‐depth proteomics reveal plasma protein signatures that reflect common networks/pathways liver cirrhosis, and determine whether cirrhosis‐related signature linked development HCC among hepatitis B virus (HBV) carriers. first compared profiles using 174‐antibody microarray system between three groups HBV carriers with different Child's grades which...
Abstract Background AD16 is a Class 1.1 new drug candidate for Alzheimer’s disease (AD), which has demonstrated potential benefits in AD by reducing neuroinflammation preclinical studies. Herein, the pharmacokinetics (PK), safety, and tolerability of single multiple-dose effect food were assessed healthy Chinese adults. Methods Single-center, randomized, placebo-controlled, double-blind studies conducted multiple ascending doses. A total 62 subjects enrolled single-dose groups; 10 each 5,...
Understanding the multifactorial changes involved in kidney and heart after acute myocardial infarction (AMI) is prerequisite for further mechanisms early intervention, especially autophagy changes. Here, we discussed role of adaptive rats with AMI. A rat model AMI was established by ligating left anterior descending branch coronary artery. Animals were sacrificed at 2 4 weeks operation to assess morphological functional kidney, as well pathway. In vitro, HK-2 AC16 cell injuries pathway...
Background Typical treatments for cervical high-grade squamous intraepithelial lesion (HSIL) are invasive procedures. However, these procedures often come with several severe side effects, despite their positive effects on HSIL. 5-aminolevulinic acid photodynamic therapy (ALA-PDT) is a non-invasive treatment that has been successfully used to treat low-grade (LSIL). In this study, we aimed further investigate the clinical efficacy and safety of ALA-PDT in patients Methods A total 40 aged 20...
Background In recent years, the relationship between periodontal disease (PD) and atherosclerosis (AS) has garnered significant scholarly attention. Chronic inflammation induced by PD may promote onset progression of AS through multiple mechanisms. Given increasing global incidence both AS, which adversely affects patients’ quality life longevity, further investigation into interplay is substantial clinical importance. This study aims to conduct a comprehensive analysis association using...
To explore the impacts of clinical pulmonary infection score (CPIS) on duration and defined daily doses (DDDs) antibiotics in patients with bacterial severe pneumonia intensive care unit (ICU).Patients pneumonia, whose antibiotic usage was prescribed guide CPIS, admitted to ICU respiratory infectious disease ward Guizhou Medical University Affiliated Hospital from May 2017 October were enrolled as CPIS group. Patients first > 5 given antimicrobial therapy, dynamically evaluated every 2-3...
Abstract Objective The purpose of this retrospective study was to investigate and compare the clinical, radiographic, pathological, pathogenesis, therapeutic features simple bone cysts (SBCs) aneurysmal (ABCs) jaw. Methods 35 patients with SBCs 6 ABCs who received treatment at Department Oral Maxillofacial Surgery, Zhejiang University School Medicine from 2017 2022 were followed up reviewed retrospectively. Results included 41 patients, accounting for 2.14% all jaw pathologies, having ABCs;...
To establish a clinical diagnostic scoring system for septic cardiomyopathy (SCM) and evaluate its efficacy.A prospective cohort study was performed. Patients with sepsis shock admitted to the department of emergency China Rehabilitation Research Center were enrolled from January 2019 December 2020. The baseline information, medical history, heart rate (HR), mean arterial pressure (MAP), body temperature respiratory (RR) on admission recorded. Laboratory indexes such as white blood cell...