Nobiletin (NOB), a flavonoid with significant antioxidant potential, holds promise for treating nonalcoholic fatty liver disease (NAFLD). In this work, we aim to assess the effects and investigate molecular mechanisms of NOB on NAFLD. After using methionine choline-deficient diet induce C57BL/6J mice, as well oleic acid HepG2 L02 cells, administered an intervention. The results indicated that significantly ameliorated lipid deposition, oxidative stress, inflammation in NAFLD both models. Its...

Nobiletin (NOB) is a naturally occurring compound, commonly found in citrus peel, that shows hepatoprotective and lipid-reducing effects. However, the lipid biomarkers potential improvement mechanisms have not been adequately explored. Therefore, we investigated ameliorative effect molecular mechanism of NOB on NAFLD induced by high-fat diet mice. The results showed supplementation with over 12 weeks markedly improved glucose tolerance, serum profiles, inflammatory factors, hepatic...

Nowadays cancers pose a great threat to the health of human beings. Based on studies flavonoids and other bioactive compounds <i>Citrus</i> fruits in current literature, it was widely suggested that consumption is beneficial prevention treatment chronic diseases including cancers. In past decades, study concerning has covered various areas type, content distribution fruits; their variation between wild cultivated genotypes; antioxidant, anti-inflammation, anti-aging, antimicrobial...

Summary The flavonoids of citrus peel extracts ( CPE ) were encapsulated by pectin nanoparticles PN s), in an attempt to control the releasing property and improve their antioxidant activity. physiochemical properties obtained s characterised. Flavonoid composition before after encapsulation determined. In vitro release profiles activity further evaluated. Results showed size spherical was 271.5 ± 5.3 nm. Interestingly, simulated gastric fluid SGF ), 73% released from naked 2 h, while only...

Nonalcoholic liver disease (NAFLD) is a pathological condition characterized by excessive fat deposition in the liver, and NAFLD usually has close relationship with obesity or metabolic syndrome. Currently, oxidative stress considered as an important risk factor progression of NAFLD, therefore, effective amelioration emerged promising way to improve NAFLD. Tangeretin natural compound having various pharmacological activities including antioxidation hepatoprotection. However, whether...

Longan, a popular fruit in Asia, has been used traditional Chinese medicine to treat several diseases for centuries. Recent studies have indicated that longan byproducts are rich polyphenols. The aim of this study was analyze the phenolic composition byproduct polyphenol extracts (LPPE), evaluate their antioxidant activity vitro, and investigate regulating effect on lipid metabolism vivo. results LPPE 231.350 ± 21.640, 252.380 31.150, 558.220 59.810 (mg Vc/g) as determined by DPPH, ABTS,...

AimsThe aim of this study was to investigate the protective effect HLJDD on septic rats and underlying mechanisms.Materials methodsAdult male Sprague–Dawley (SD) adult (150–180 g) were randomly divided into following 5 groups (n = 7 per group): Sham group, caecal ligation puncture (CLP) + CLP (Huang Lian Jie Du Decoction, HLJDD) group (1 g/mL/100 g), Rap (H. Rap) (Rap: 3 mg/kg), HLJDD+3-MA 3-MA) (3-MA: 30 mg/kg). Rapamycin (Rap) 3-methyladenosine (3-MA) used activate inhibit autophagy,...

The fruits of Fortunella Swingle are widely consumed as fresh and traditional medicine in China. China is the origin center has largest cultivated area genus Fortunella. In this study, chemical compositions ethanol extracts major types including japonica Swingle, margarita crassifolia 1 (Lanshang) 2 (Liuyang) were determined using ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC Q-TOF/MS) method, their antioxidant activities evaluated. 12...

It is currently thought that excess fatty acid-induced lipotoxicity in hepatocytes a critical initiator the development of nonalcoholic liver disease (NAFLD). Lipotoxicity can induce hepatocyte death; thus, reducing one most effective therapeutic methods to combat NAFLD. Abundant evidence has shown hesperidin (HSP), type flavanone mainly found citrus fruits, able ameliorate NAFLD, but molecular mechanisms are unclear. We previously reported pyroptosis contributed NAFLD and inhibiting...

The primary catalyst for nonalcoholic fatty liver disease (NAFLD) is widely recognized as the induction of lipotoxicity in hepatocytes by an excess acids. In China,

With high mortality and poor prognosis, hepatocellular carcinoma (LIHC) has become the fourth leading cause of cancer-related deaths worldwide. Most LIHC patients missed best treatment period because untimely diagnosis. For others, even if they are temporarily cured, have to face a very low prognostic survival rate risk recurrence. Based on characteristics abnormal proliferation uncontrolled growth tumor cells. Cell Division Cycle Associated ( CDCA ) family genes, which responsible for...

Pathological epithelial‑mesenchymal transition (EMT) has been shown to fulfill a key role in the development and progression of variety lung diseases. It demonstrated that inflammatory microenvironment is decisive factor inducing pathological EMT. Hexacylated lipopolysaccharide (LPS) [or proacylated (P‑LPS), which functions as proinflammatory lipopolysaccharide] one most effective Toll‑like receptor 4 (TLR4) agonists. Furthermore, pentacylated tetracylated form (or A‑LPS, anti‑inflammatory...

Longan is widely consumed due to its high nutritional value. The growing area has substantial effect on nutrient component and secondary metabolism of fruits. aim this study was analyze the differences in physicochemical characteristics, polyphenol profiles, antioxidant activity longan fruits grown four regions China. Two representative cultivars 'Shixia' 'Chuliang' located Chongqing, Guanxi, Zhanjiang Hainan were collected analyzed. results showed that fruit weights, edible rates, total...

This study investigated the effect of Erchen Decoction(ECD) on prevention non-alcoholic steatohepatitis(NASH) in mice and explored its possible mechanism, so as to provide scientific data for clinical application ECD NASH. C57BL/6 male were randomly divided into normal group(methionine choline supplement, MCS), model deficient, MCD), low-dose group(ECD＿L, 6 g·kg~(-1)), medium-dose group(ECD＿M, 12 high-dose group(ECD＿H, 24 with eight each group. The MCS group was fed an diet, other groups MCD...

Background: Sepsis is defined as a life‐threatening disease. Autophagy and the microbiome are increasingly connected with sepsis. The aim of this study was to investigate protective effect autophagy possible mechanisms. Methods: septic rat model established by cecal ligation perforation (CLP). Rapamycin (Rap), 3‐methyladenine (3‐MA), chloroquine (CQ) were administered interfere autophagy. Western blot (WB) used detect expression key proteins in Hematoxylin eosin (H&amp;E) staining...

Hypercholesterolemia is highly associated with cardiovascular diseases (CVDs) such as atherosclerosis.

Abstract Background As a new type of virus that seriously threatens public health worldwide, there are currently very limited effective methods prevention and control for severe acute respiratory syndrome (SARS)-CoV-2. Therefore, people urgently need an efficient specific mechanism to prevent COVID-19. CRISPR/Cas13 is natural defense system in bacteria has been successfully applied the treatment many viruses, including SARS-CoV-2. How efficiently specifically destroy SARS-CoV-2 RNA avoid...

2-Hydroxyeupatolide (2-HE), a sesquiterpene lactone, is potential agent to improve LPS-induced acute mouse inflammation damage.