A5064172284- Immunotherapy and Immune Responses
- Nanoplatforms for cancer theranostics
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Innovative Microfluidic and Catalytic Techniques Innovation
- CAR-T cell therapy research
- RNA Interference and Gene Delivery
University of California, Irvine
2022-2023
Academia Sinica
2021
Institute of Biomedical Sciences, Academia Sinica
2021
In this study, efficient T cell activation is demonstrated using cell-sized artificial antigen-presenting cells (aAPCs) with protein-conjugated bilayer lipid membranes that mimic biological membranes. The highly uniform aAPCs are generated by a facile method based on standard droplet microfluidic devices. These able to activate the in peripheral blood mononuclear cells, showing 28-fold increase interferon gamma (IFNγ) secretion, 233-fold antigen-specific CD8 expansion, and 16-fold of CD4...
The growing enthusiasm for cancer immunotherapies and adoptive cell therapies has prompted increasing interest in biomaterials development mimicking natural antigen-presenting cells (APCs) T-cell expansion. In contrast to conventional bottom-up approaches aimed at layering synthetic substrates with activation cues, transformation of live dendritic (DCs) into artificial APCs (aAPCs) is demonstrated herein using a facile minimally disruptive hydrogelation technique. Through direct...
Abstract In this study, efficient T cell activation is demonstrated using cell-sized artificial antigen-presenting cells (aAPCs) with protein-conjugated bilayer lipid membranes that mimic biological membranes. The highly uniform aAPCs are generated by a facile method based on standard droplet microfluidic devices. These able to activate the in peripheral blood mononuclear (PBMCs), showing 28-fold increase IFNγ secretion, 233-fold antigen-specific CD8 expansion, and 16-fold of CD4 expansion....
Robust and modular systems for T cell expansion have immense utilities clinical development immunoengineering research. In article 2101190, Che-Ming J. Hu co-workers demonstrate a photoactivated intracellular radical polymerization technique that transforms live dendritic cells into functional T-cell-stimulating biomaterial, which effectively enhances adoptive therapy against cancer in mice.