A5066675631- Acute Ischemic Stroke Management
- Cardiac Health and Mental Health
- Stroke Rehabilitation and Recovery
- Tryptophan and brain disorders
- Venous Thromboembolism Diagnosis and Management
- Ion channel regulation and function
- Cardiovascular Function and Risk Factors
- Biochemical effects in animals
- Electroconvulsive Therapy Studies
- Cerebrovascular and Carotid Artery Diseases
- Liver Disease Diagnosis and Treatment
- Migraine and Headache Studies
- Neuroscience of respiration and sleep
- Reproductive System and Pregnancy
- Pelvic floor disorders treatments
- Telomeres, Telomerase, and Senescence
- Advancements in Transdermal Drug Delivery
- Essential Oils and Antimicrobial Activity
- Drug Solubulity and Delivery Systems
- Mindfulness and Compassion Interventions
- Heme Oxygenase-1 and Carbon Monoxide
- Gestational Trophoblastic Disease Studies
- Frailty in Older Adults
- Gout, Hyperuricemia, Uric Acid
- Neuroblastoma Research and Treatments
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024-2025
Chongqing Medical University
2024-2025
Hospital of Hebei Province
2023-2025
Beijing Tian Tan Hospital
2024
Capital Medical University
2024
Chinese PLA General Hospital
2024
Chengdu University of Traditional Chinese Medicine
2024
Hebei General Hospital
2023-2024
Hebei Medical University
2021-2024
Wenzhou Medical University
2021-2024
Early maturity is one of the most important and complex agronomic traits in upland cotton (Gossypium hirsutum L). To dissect genetic architecture this agronomically trait, a population consisting 355 germplasm accessions was genotyped using specific-locus amplified fragment sequencing (SLAF-seq) approach, which subset 185 lines representative diversity among phenotypically characterized for six early four environments. A genome-wide association study (GWAS) conducted generalized linear model...
ABSTRACT Lycopene is a natural plant extract widely studied for its powerful antioxidant and neuroprotective effects. Emerging evidence suggests that it also possesses potential antidepressant properties. Compared to commonly used clinical antidepressants, lycopene offers higher safety; however, underlying mechanisms remain unclear. Therefore, this study aims explore the through which exerts We employed chronic social defeat stress (CSDS) model induce depressive‐like behaviors in mice,...
With the increasing popularity of dogs as pets, cases hydrocephalus have risen significantly. Due to ongoing challenges in diagnosis and treatment hydrocephalus, advancements magnetic resonance imaging (MRI) technology greatly enhanced diagnostic capabilities small animal clinical practice. Assessing ventricular size is crucial for management other neurological disorders. However, methods quantifying evaluating severity requires further optimization. This study involved 137 17 normal dogs....
Background: Stroke-associated pneumonia (SAP) is associated with poor prognosis after acute ischemic stroke (AIS). Purpose: This study aimed to describe the parameters of coagulation function and evaluate association between fibrinogen-to-albumin ratio (FAR) SAP in patients AIS. Patients methods: A total 932 consecutive AIS were included. Coagulation measured at admission. All classified into two groups according optimal cutoff FAR point which sum specificity sensitivity was highest....
Background and Purpose: The results regarding the independent association between homocysteine (Hcy) levels post-stroke cognitive impairment (PSCI) were inconsistent. effect of age on this has yet to be explored. This study aims determine relationship Hcy levels, age, in a population. Methods: A total 592 patients with acute ischemic stroke (AIS) completed follow-up. Serum measured enzymatically by spectrophotometry within 24 h admission. Cognitive function was evaluated Mini-Mental State...
Although large artery atherosclerosis (LAA) is the most common type of cerebral infarction, non-LAA not uncommon. The purpose this paper to investigate prognosis patients with and establish a corresponding nomogram.Between June 2016 2017, we had 1101 admissions for acute ischemic stroke (AIS). Of these, 848 were LAA 253 non-LAA. Patients followed up every 3 months minimum 1 year follow-up. After excluding who lost follow-up did meet inclusion criteria, total 152 included in cohort study....
In present, there was no detailed report on the formulation optimization and quality evaluation of aprepitant (APT) injectable lipid emulsion (APT-IE). The aim present investigation to prepare evaluate its properties APT-IE loaded with an APT phospholipid complex (APT-PC) in vitro vivo. APT-PC obtained by solvent evaporation phospholipids, then analyzed X-ray diffraction, Fourier transform infrared spectroscopy differential scanning calorimetry. Lipid emulsions are a new that can reduce side...
Background: Post-stroke depression (PSD) constitutes an essential complication of stroke and is associated with high-risk unfavorable outcome after stroke. The main objective this prospective study was to determine the relationship between early-onset PSD (1 month stroke) functional outcomes 5 years baseline enrollment. Methods: Four hundred thirty-six patients who met criteria were included in from October 2013 February 2015. follow-up time for each patient ~5 years, every 3 months....
The aim of this investigation was to develop an etomidate intravenous lipid emulsion (ETM-ILE) and evaluate its properties in vitro vivo. Etomidate (ETM) is a hydrophobic drug, organic solvents must be added injectable solution (ETM-SOL) aid dissolution, that causes various adverse reactions on injection. Lipid emulsions are novel drug formulation can improve loading reduce reactions. ETM-ILE prepared using high-pressure homogenization. Univariate experiments were performed select key...
In order to devise more effective penetration enhancers, 4-O-acylterpineol derivatives which were expected be hydrolyzed into nontoxic metabolites by esterase in the living epidermis, synthesized from 4-terpineol (4-TER) enantiomers and straight chain fatty acids. Their promoting activities on SR-flurbiprofen its tested across full-thickness rabbit skin, as well correlate under vitro vivo conditions. The permeation studies indicated that both d-4-O-acylterpineol l-4-O-acylterpineol had...
Acute pancreatitis (AP) is a non-infectious pancreatic enzyme-induced disorder, life-threatening inflammatory condition that can cause multi-organ dysfunction, characterized by high morbidity and mortality. Several therapies have been employed to target this disorder; however, few happen be effectively employable even in the early phase. PFKFB3(6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-3) critical regulator of glycolysis upregulated under inflammatory, mitogenic, hypoxia...
To explore the structure-activity connections of amphiphilic permeation enhancers containing length hydrophobic chains as well properties polar head, O-acylgeraniol and O-acylnerol derivatives were synthesized from geraniol/nerol (cis-isomer geraniol) pharmaceutical excipient acids in this research. Their promotion percutaneous absorption three drugs model, flurbiprofen (FP), isosorbide dinitrate (ISDN) donepezil (DNP), which selected based on their physicochemical properties, was tested by...
Pain is one of the most common symptoms malignant peritoneal mesothelioma. Therefore, analgesia serves an indispensable role in treatment this condition. Morphine a representative opioid, which widely used clinical practice; however, excessive or unreasonable application can cause poisoning. Few cases morphine poisoning have been reported, and patients with mesothelioma are even more rare. Here, we present case patient The had high abdominal tumor load, hepatorenal insufficiency, was treated...
Sleep disorders are prevalent after stroke, resulting in high recurrence rates and mortality. But the biomarkers of sleep stroke patients remain to be elucidated. This study aimed explore relationship between total bilirubin-to-uric acid ratio (TUR) quality acute ischemic (AIS).Three hundred twenty-six AIS were recruited followed up 1 month our study. Serum bilirubin uric levels obtained within 24 h admission. The Pittsburgh Quality Index (PSQI) was used evaluate stroke. We conducted...
Migraine is implicated in oxidative stress. The balance score (OBS) assesses the combined impact of diet and lifestyle on antioxidant diseases. However, association between OBS migraine remains underexplored.