A5101824916- Radiation Detection and Scintillator Technologies
- Thin-Film Transistor Technologies
- CCD and CMOS Imaging Sensors
- Rheumatoid Arthritis Research and Therapies
- Particle Detector Development and Performance
- Cancer, Hypoxia, and Metabolism
- T-cell and B-cell Immunology
- Advanced X-ray and CT Imaging
- Systemic Lupus Erythematosus Research
- RNA modifications and cancer
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- Cellular Mechanics and Interactions
- Proteoglycans and glycosaminoglycans research
- Medical and Biological Ozone Research
- solar cell performance optimization
- Neurological Disorders and Treatments
- Ethics in Clinical Research
- High Altitude and Hypoxia
- Autoimmune and Inflammatory Disorders Research
- Artificial Intelligence in Healthcare and Education
- Neurological Disease Mechanisms and Treatments
- Digital Radiography and Breast Imaging
- Ginkgo biloba and Cashew Applications
- Tea Polyphenols and Effects
Zhongda Hospital Southeast University
2024
Wuhan University
2017-2024
Zhongnan Hospital of Wuhan University
2017-2024
National Health and Family Planning Commission
2024
Tongji Hospital
2022
Xi'an Honghui Hospital
2021
Xi'an Jiaotong University
2021
Tangshan Gongren Hospital
2008-2019
Nanjing General Hospital of Nanjing Military Command
2019
First Affiliated Hospital of Shihezi University Medical College
2018
Hypoxia-inducible factor1 (HIF-1) is an essential transcription factor for cellular adaptation to decreased oxygen availability. In normoxia the oxygen-sensitive alpha-subunit of HIF-1 hydroxylated on Pro564 and Pro402 thus targeted proteasomal degradation. Three human oxygen-dependent alpha prolyl hydroxylases (PHD1, PHD2, PHD3) function as sensors in vivo. Furthermore, asparagine hydroxylase FIH-1 (factor inhibiting HIF) has been found hydroxylate Asp803 C-terminal transactivation domain,...
Although aberrant expression of miR-34a, an essential tumor suppressor miRNA, has been frequently observed in colon cancer (CCa), whether miR-34a can regulate CCa progression by modulating other facets this malignancy (such as multidrug resistance, MDR) remains unknown. Here, we report for the first time that was significantly downregulated clinical samples from oxaliplatin-resistant patients and experimentally established multidrug-resistant cells. By using histoculture drug response assay,...
Our previous works have shown that bone marrow stromal cells secrete thymosin beta4 (Tbeta4) and AcSDKP. Tbeta4 AcSDKP are existed in the conditioned medium of endothelial cells. They exerted inhibitory effects on hematopoietic then had protective effect early cells, which were cultured presence stimulators. Thymosin consists 43 peptides with a molecular weight 4963. It contains at its N-terminal end sequence acetylated tetrapeptide Ac-N-Ser-Asp-Lys-Pro (AcSDKP). This study was performed to...
Signal measurements for a variety of pixelated a-Si:H imaging arrays irradiated by megavoltage beams are reported. Data presented 6-, 10-, and 15-MV beam energies screens containing gadolinium-oxysulfide calcium tungstate. These results quantitative radiation signal sizes reported such arrays. The initialization times these performance various pitches with respect to measured values is compared. part an ongoing effort develop flat-panel, real-time gamma X-ray imagers.< <ETX...
An electronic data acquisition system for pixelated, two-dimensional, amorphous silicon x-ray imaging arrays has been developed. The was designed in a modular fashion with digital control provided by field-programmable logic devices. This approach allows sections of the design to be upgraded little impact an other aspects system. Good analog noise performance obtained matching preamplifier characteristics array outputs. this is presented and its quantified.< <ETX...
The first diagnostic X-ray signal measurements for two-dimensional amorphous silicon imaging arrays are presented. Data were acquired a variety of phosphor screens, energies ranging from 70 to 120 kVp, both in the presence and absence phantom simulating attenuation human chest. Results reported terms pixel charge per unit exposure at array. Also, linearity response with as function sensor bias, data quantifying degree reciprocity reported. Significant results include: (a) remained linear...
In vitro T cell differentiation techniques are essential for both functional and mechanistic investigations of CD4
e19556 Background: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease. Recently, based on in-depth genomic analysis, new taxonomies for DLBCL have been proposed. Genetic subtype MCD predominantly enriched with receptor-dependent NF-κB activation and well responded to Bruton’s tyrosine kinase (BTK) inhibitors. Ibrutinib rituximab plus cyclophosphamide, doxorubicin, vincristine, prednisone (R-CHOP) proved the efficacy in patients PHOENIX study. Orelabrutinib novel BTK inhibitor...
A readout system is developed to facilitate the digitization and subsequent display of image data from two-dimensional, pixellated, flat-panel, amorphous silicon imaging arrays. These arrays are designed specifically for medical X-ray applications. The based on hardware software various experiments at CERN Fermi National Accelerator Laboratory. Additional analog signal processing digital control electronics constructed this application. form resulting acquisition reported, aspects its...
Objective: To explore the value of Clermont score in detection intestinal mucosal ulcer Crohn's disease (CD). Methods: From May 2015 to August 2017, 45 patients (28 males and 17 females; median age was 25 years) were confirmed have ileocolic CD by endoscopic pathological examinations at Nanjing General Hospital. All underwent MRE DWI examinations. Based on appearance mucosa endoscopically, intestine segments from divided into three groups, namely, no ulceration group (NU), superficial (SU),...
Background: Mesenchymal stem cells (MSCs) have been shown to elicit cardioprotective effects in polymicrobial sepsis induced by cecal ligation and puncture (CLP). However, the underlying mechanisms remain obscure. While recent studies indicated that miR-223 is highly enriched MSC-derived exosomes, whether exosomal contributes MSC-mediated cardioprotection unknown. Methods Results: MSCs harvested from bone marrow of female pre-miR-223 knockout (KO) wild-type (WT) mice were injected into male...
The concept of composite imaging detectors in which a flat-panel array precedes second level detection is presented. In radiotherapy, dual-energy X-ray projection imager would consist pair stacked, imagers. upper with an overlying converter and serve as diagnostic imager. lower metal sheet/phosphor screen megavoltage Such be significant assistance helping to resolve the patient localization problem radiotherapy by facilitating correlation anatomy obtained images position portal field....
Objective To understand the current situation of work pressure human organ donation coordinator (referred to as coordinator) and explore its influencing factors, provide a theoretical basis for implementation feasible decompression interventions in future. Methods A total 182 full-time or part-time coordinators registered nationwide 2016 were randomly selected surveyed using questionnaires, including general demographic sociology data stress scales. Two independent sample t-tests...
The study aimed to detect the expression level of interleukin-37 (IL-37) in patients with rheumatoid arthritis (RA) and explore its clinical significance. A total 40 peripheral blood samples from active stable RA were collected (40 RA), healthy volunteers was used as control group. Peripheral serum mononuclear cells (PBMCs) isolated. IL-37 mRNA PBMCs detected by real-time fluorescence quantitative PCR. Serum levels IL-37, factor (RF), anticyclic citrullinated peptide antibody (CCP) measured...