A5100368221- Pancreatic function and diabetes
- Viral Infectious Diseases and Gene Expression in Insects
- RNA modifications and cancer
- Pediatric Pain Management Techniques
- Nutrition, Genetics, and Disease
- Liver physiology and pathology
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Tuberculosis Research and Epidemiology
- biodegradable polymer synthesis and properties
- Protein Tyrosine Phosphatases
- vaccines and immunoinformatics approaches
- ATP Synthase and ATPases Research
- Genetic and rare skin diseases.
- Fluid Dynamics and Mixing
- Tumors and Oncological Cases
- Pain Management and Placebo Effect
- Inhalation and Respiratory Drug Delivery
- Cancer, Stress, Anesthesia, and Immune Response
- Advanced X-ray and CT Imaging
- Pancreatic and Hepatic Oncology Research
- Atomic and Subatomic Physics Research
- Polyamine Metabolism and Applications
- Biopolymer Synthesis and Applications
- Hedgehog Signaling Pathway Studies
Suizhou Central Hospital
2018-2024
National Institute for Communicable Disease Control and Prevention
2022
First Affiliated Hospital of Zhengzhou University
2018
First Affiliated Hospital of Shihezi University Medical College
2011-2018
Chinese Academy of Sciences
2012-2015
University of Chinese Academy of Sciences
2013-2015
Dalian Institute of Chemical Physics
2012-2015
Dalian University
2014
Dalian University of Technology
2014
Although aberrant expression of miR-34a, an essential tumor suppressor miRNA, has been frequently observed in colon cancer (CCa), whether miR-34a can regulate CCa progression by modulating other facets this malignancy (such as multidrug resistance, MDR) remains unknown. Here, we report for the first time that was significantly downregulated clinical samples from oxaliplatin-resistant patients and experimentally established multidrug-resistant cells. By using histoculture drug response assay,...
Abstract Cell microencapsulation is a promising approach for cell implantation, cell‐based gene therapy, and large‐scale culture. The well‐studied α‐AP (alginate–α‐poly‐ L ‐lysine) microcapsules have been restricted to cell‐culture clinical applications because of high costs cytotoxic effects in some cases. This study used ϵ‐poly‐ ‐lysine (ϵ‐PLL), high‐biocompatible low‐cost food additives produced by fermentation, prepare ϵ‐AP (alginate–ϵ‐PLL) with various thickness membranes swelling...
Dual-specificity phosphatase-2 (DUSP2), a negative regulator of extracellular‑regulated kinase activity, has been identified as an important with emerging roles in cancer. However, the clinical significance DUSP2 colorectal cancer (CRC) remains to be fully elucidated. In present study, expression was investigated using immunohistochemistry 96 patients CRC. Cell viability estimated cell counting kit‑8 assay, and apoptosis by flow cytometry. The relationship between patient characteristics,...
Solitary pulmonary nodules (SPNs) are one of the most common chest computed tomography (CT) abnormalities clinically. We aimed to investigate value non-contrast enhanced CT (NECT), contrast (CECT), perfusion imaging (CTPI), and dual- energy (DECT) used for differentiating benign malignant SPNs with a multi-institutional prospective study.Patients 285 were scanned NECT, CECT, CTPI DECT. Differences between on CTPI, DECT separately (NECT combined DECT, methods A, B, C) or in combination...
Background: The major challenge to the treatment of advanced colorectal cancer (CRC) is persistent occurrence chemoresistance. One established etiologies existence stem-like cells (CSCs), due which, tumors show resistance external therapeutic challenges. Objective: forkhead-box A3 (FOXA3) a potent transcription factor that potentiates acquisition and maintenance stemness fate in many physiological systems. However, its effect on stemness, particularly treatment, has not been explored CRC,...
Immobilization of hepatocytes in microcapsules has been a potentially alternative methodology for bioartificial livers (BALs). Moreover, the stability and permeability are key parameters these microcapsules. However, alginate-based unstable if surrounding medium disrupts ionic interactions between alginate polycation. As hundreds components included human plasma, plasma need to be sufficiently investigated. In present study, three kinds was evaluated when they were immersed plasma. Our...
The discovery of immunodominant antigens is great significance for the development new especially sensitive diagnostic reagents and effective vaccines in controlling tuberculosis (TB). In present study, we targeted T-Cell epitope-rich fragment (nucleotide position 109-552) Rv1566c from Mycobacterium (MTB) got a recombinant protein Rv1566c-444 full-length with Escherichia coli expression system, then compared their performances TB diagnosis immunogenicity mouse model. results showed that had...
Stirred tank bioreactors are the most widely used method for large-scale culture of mammalian cells. However, scale stirred is limited by insufficient oxygen/nutrient mixing and accumulation waste products in high cell density cultures. The effective to solve these problems increase stirring rate; this usually leads increased proliferation, but can decrease utilization nutrients recombinant protein synthesis. To investigate effects rate on metabolism, yield microencapsulated Chinese hamster...
Introduction Islet purification is usually performed using the density gradient separation method, but purity of islets low because exocrine cells and embedded are hard to remove by only method. The aim this study was establish a new islet process comprising hypertonic-hypotonic treatment step followed centrifugation improve islets. Methods Plackett-Burman method used determine which factors had significant influence on obtained after step. Results hypertonic solution concentration...
e24058 Background: Breakthrough cancer pain (BTcP) can significantly impact the life quality of patient. Wide-used rapid-onset opioids (ROOs) for BTcP are transmucosal fentanyl-based preparations. Inhaled fentanyl demonstrated similar pharmacokinetic properties as intravenous administration in healthy volunteers. Fentanyl aerosol be generated via hand-held drug-device delivery system, providing rapid, consistent multi-dose administration. inhalant was explored alternative treatment patients...