A5041525318- Drug-Induced Adverse Reactions
- Contact Dermatitis and Allergies
- Urticaria and Related Conditions
- Food Allergy and Anaphylaxis Research
- Pharmacovigilance and Adverse Drug Reactions
- COVID-19 Clinical Research Studies
- COVID-19 diagnosis using AI
- SARS-CoV-2 and COVID-19 Research
- Asthma and respiratory diseases
- Telemedicine and Telehealth Implementation
- Long-Term Effects of COVID-19
- Mycobacterium research and diagnosis
- Pneumonia and Respiratory Infections
- Allergic Rhinitis and Sensitization
- Pneumocystis jirovecii pneumonia detection and treatment
- Respiratory and Cough-Related Research
- Tuberculosis Research and Epidemiology
- Autoimmune Bullous Skin Diseases
- Mast cells and histamine
- COVID-19 and healthcare impacts
Austin Health
2019-2025
Peter MacCallum Cancer Centre
2020-2025
Peter Doherty Institute
2024-2025
The University of Melbourne
2020-2024
Austin Hospital
2021-2023
National Cancer Centre Japan
2023
Monash Health
2023
Antibiotic Research UK
2022
Alfred Health
2017
Importance Fewer than 5% of patients labeled with a penicillin allergy are truly allergic. The standard care to remove the label in adults is specialized testing involving prick and intradermal skin followed by an oral challenge penicillin. Skin resource intensive, limits practice specialist-trained physicians, restricts global population who could undergo delabeling. Objective To determine whether direct noninferior low-risk allergy. Design, Setting, Participants This parallel, 2-arm,...
Accurate diagnosis and subsequent treatment of latent tuberculosis infection (LTBI) is essential for TB elimination. However, the absence a gold standard test diagnosing LTBI makes assessment true prevalence accuracy diagnostic tests challenging. Bayesian class models can be used to make inferences about disease sensitivity specificity using data on concordance between tests. We performed largest meta-analysis date aiming evaluate performance tuberculin skin (TST) interferon-gamma release...
Critically ill patients are vulnerable to penicillin allergy labels that may be incorrect. The validity of skin testing in intensive care units (ICUs) is uncertain. Many low risk, and validated tools exist identify those amenable direct oral challenge. This pilot randomised controlled trial explored the feasibility, safety, enteral challenge for low-risk critical illness. Consenting with a label (PAL) (PEN-FAST risk assessment score < 3) four ICUs (Melbourne, Australia) were 1:1 (250 mg...
Introduction Penicillin allergy labels (PALs) are reported in 1 10 hospitalised patients globally and associated with inferior patient, hospital microbiological outcomes; however, the majority incorrect should be removed. Direct oral penicillin challenge has been demonstrated to a safe effective method for removal of PALs. However, question whether single dose is sufficient ascertain true status remains unanswered, some studies suggesting that extended challenges 3 or more days superior...
Introduction Penicillin allergies are highly prevalent in the healthcare setting and associated with prescription of second-line inferior antibiotics. More than 85% all penicillin allergy labels can be removed by skin testing 96%–99% low-risk direct oral challenge. An internally externally validated clinical assessment tool for allergy, PEN-FAST, identify a without need testing; score less 3 has negative predictive value 96.3% (95% CI, 94.1 to 97.8) presence allergy. It is hypothesised that...
Objectives We report on the key clinical predictors of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and present a decision rule that can risk stratify patients for COVID-19. Design, participants setting A prospective cohort assessed COVID-19 at screening clinic in Melbourne, Australia. The primary outcome was positive test from nasopharyngeal swab. backwards stepwise logistic regression used to derive model variables predictive test. Internal validation final...
Abstract Due to the ongoing COVID-19 pandemic and increased pressure on testing resources, understanding clinical epidemiological features closely associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is vital at point of care enable risk stratification. We demonstrate that an internally derived validated decision rule, COVID-MATCH65, has a high sensitivity (92.6%) NPV (99.5%) for SARS-CoV-2 could be used aid risk-assessment resource allocation diagnostics.
Self-reported penicillin allergies are highly prevalent in hospitalised patients and associated with poor health service outcomes. Critically ill have historically been underrepresented prospective delabelling studies part due to concerns around clinical stability reliability of skin testing. Allergy assessment tools exist identify low-risk allergy phenotypes facilitate direct oral challenge delabelling. PEN-FAST is a decision rule that has validated predict true cohort non-critically...
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Abstract We describe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–specific immune responses in a patient with lymphoma and recent programmed death 1 (PD-1) inhibitor therapy late onset of disease 2019 prolonged SARS-CoV-2 replication, comparison to age-matched immunocompromised controls. High levels HLA-DR+/CD38+ activation, interleukin 6, 18 the absence B cells PD-1 expression was observed. SARS-CoV-2–specific antibody were absent T minimally detected. This case highlights...
Patient reported antibiotic allergies, so-called allergy labels (AAL) are highly prevalent amongst hospitalized patients globally1 . The highest prevalence of AALs has been found to be in immunocompromised patients, particular transplant with a large U.S. study reporting 29% solid organ and stem cell recipients2 Whilst studies have demonstrated that associated the use broad-spectrum antibiotics2 , impact testing (AAT) on this patient cohort remains ill defined.
The coronavirus-2019 (COVID-19) pandemic and restrictions placed on movement to prevent its transmission have led a surge in demand for remote medical care. We investigated whether COVID-Care, patient-reported, telehealth, symptom monitoring system, was successful at delivering safe care these patients leading decreased hospital presentations.We performed single centre, prospective, interventional cohort study with symptomatic outpatients who presented COVID-19 screening Austin Health,...
Abstract Background: Self-reported penicillin allergies are highly prevalent in hospitalised patients and associated with poor health service outcomes. Critically ill have historically been underrepresented prospective delabelling studies part due to concerns around clinical stability reliability of skin testing. Allergy assessment tools exist identify low-risk allergy phenotypes facilitate direct oral challenge delabelling. PEN-FAST is a decision rule that has validated predict true cohort...
Introduction: The COVID-19 pandemic and restrictions placed on movement to prevent its transmission has led a surge in demand for remote medical care. We investigated whether COVID-Care, patient-reported telehealth symptom monitoring system, was successful at delivering safe care these patients leading decreased hospital presentations.Methods: performed single centre, prospective, interventional cohort study with symptomatic outpatients who presented screening Austin Health, Australia....