A5043275282- Drug-Induced Adverse Reactions
- Contact Dermatitis and Allergies
- Urticaria and Related Conditions
- Food Allergy and Anaphylaxis Research
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Antibiotic Use and Resistance
- Pharmacovigilance and Adverse Drug Reactions
- Autoimmune Bullous Skin Diseases
- Pregnancy and Medication Impact
- Respiratory and Cough-Related Research
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Pediatric health and respiratory diseases
- Diabetes Treatment and Management
- Eosinophilic Disorders and Syndromes
- Cancer Immunotherapy and Biomarkers
- Inhalation and Respiratory Drug Delivery
- Coronary Artery Anomalies
- Antimicrobial Resistance in Staphylococcus
- Pharmaceutical industry and healthcare
- Respiratory Support and Mechanisms
- Dermatological and COVID-19 studies
- Biosensors and Analytical Detection
Massachusetts General Hospital
2023-2025
Harvard University
2024-2025
Austin Health
2022-2024
University of North Carolina at Chapel Hill
2019-2021
University of North Carolina Health Care
2021
The University of Western Australia
2018
University of Arkansas for Medical Sciences
2017
Ocean NanoTech (United States)
2009
Importance Fewer than 5% of patients labeled with a penicillin allergy are truly allergic. The standard care to remove the label in adults is specialized testing involving prick and intradermal skin followed by an oral challenge penicillin. Skin resource intensive, limits practice specialist-trained physicians, restricts global population who could undergo delabeling. Objective To determine whether direct noninferior low-risk allergy. Design, Setting, Participants This parallel, 2-arm,...
Importance Antibiotic allergy labels (AALs) impact patient health and perioperative outcomes. delabeling could improve antibiotic prescribing infection-related outcomes perioperatively. Objective To assess the feasibility safety of assessment in anesthesiologist-led preoperative clinics expand efforts outside specialist clinics. Design, Setting, Participants This randomized clinical trial was a multicenter, phase 2 conducted between December 14, 2020, October 31, 2023, at outpatient 3...
The authors declare no conflicts of interest. Data sharing is not applicable to this article as new data were created or analyzed in study.
OBJECTIVE: To estimate the feasibility, acceptability, and safety of outpatient penicillin allergy testing among pregnant women. METHODS: We conducted a prospective cohort study at large academic hospital from March 2019 to 2020. recruited women with self-reported who underwent between 14 0/7 36 6/7 weeks gestation. RESULTS: Of 127 eligible women, 74 (58%, 95% CI 4–67%) accepted testing. Fifty completed or intended complete testing, yielding feasibility rate 68% (95% 56–78%). Among 46...
Abstract Inpatient direct oral challenge programs are increasingly deployed as part of antimicrobial stewardship initiatives to reduce the burden and impacts penicillin allergy labels on antibiotic prescribing. Using data from a prospective, multicenter cohort inpatient program, we identify key targets for delabeling aid health service implementation.
This cohort study describes the adaptation of a widely used penicillin allergy clinical decision tool for evaluation trimethoprim-sulfamethoxazole allergy.
Background Insulin growth factor-1 (IGF1) activates cell proliferation pathways and inhibits apoptosis. IGF1 is involved in tumour required for T-cell independent activation of B cells. Activated cells autoantibody production are a hallmark systemic lupus erythematosus (SLE). To investigate the possible role SLE, we studied across clinical characteristics, immunological biomarkers, disease activity organ damage SLE patients. Method In cross-sectional study, collected medication, (SLEDAI-2K)...
Objectives To estimate the prevalence of and identify modifiable risk factors for alternative antibiotics group B Streptococcus (GBS) prophylaxis in penicillin-allergic women. Methods Retrospective cohort study pregnant women within a health care network from January 1, 2014, to December 31, 2017. Included were GBS colonized, delivered at ≥ 37 weeks' gestation, reported penicillin/cephalosporin allergy. The primary outcome was use alternate prophylaxis, defined per Centers Disease Control...
To the editor—Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe cutaneous adverse (SCAR) that can occur medication exposure, including antibiotics [1]. DRESS characterized by diffuse rash, eosinophilia, organ dysfunction. However, clinical presentation be heterogenous [2], making standardized diagnostic criteria proposed RegiSCAR group critical to identification of [3]. Presentation typically delayed traditional teaching, suggesting symptom onset occurs 2–6 weeks...
Quantum dots (QDs) have received considerable attention due to their advantages that are suitable for biological studies, especially multiplexed staining assays and immunological assays. Here we report an application of QDs the detection breast cancer cells. Breast is second most common type fifth cause deaths in US world. The development QD based sensing cells involved three kinds antibodies, first was capture, labeling third imaging capture antibody, anti-Her2/neu, covalently immobilized...
Penicillin-associated exanthems in the setting of infectious mononucleosis caused by Epstein-Barr virus (EBV) are often viewed as a transient event, not true allergy. Recent evidence challenges this and suggests that notable subset patients retain penicillin hypersensitivity.
The purpose of this study was to evaluate the generation Th2 and other pro-asthmatic cytokines (interleukin [IL]-4, IL-13, IL-17 thymic stromal lymphopoietin [TSLP]) in premature infants during rhinovirus (RV) infections.This a retrospective analysis 264 subjects, aged 0 2 years with acute respiratory illness polymerase chain reaction–confirmed RV infection or nondetectable virus (controls). Patients were stratified by gestational age (GA) including severe prematurity (<32 weeks’ GA),...