A5061978120- Drug-Induced Adverse Reactions
- SARS-CoV-2 and COVID-19 Research
- Contact Dermatitis and Allergies
- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Pharmacovigilance and Adverse Drug Reactions
- Pharmaceutical studies and practices
- Immunodeficiency and Autoimmune Disorders
- Cell death mechanisms and regulation
- Asthma and respiratory diseases
- Urticaria and Related Conditions
- COVID-19 Clinical Research Studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Immunotherapy and Immune Responses
- Ocular Diseases and Behçet’s Syndrome
- COVID-19 and healthcare impacts
- Phagocytosis and Immune Regulation
- Social Media in Health Education
- Blood groups and transfusion
- Glaucoma and retinal disorders
- RNA Interference and Gene Delivery
- Respiratory and Cough-Related Research
- Infection Control and Ventilation
- T-cell and B-cell Immunology
- Cancer Immunotherapy and Biomarkers
Harvard University
2011-2025
Massachusetts General Hospital
2014-2025
Boston University
2002-2007
BackgroundThe Centers for Disease Control and Prevention state that a severe or immediate allergic reaction to the first dose of an mRNA COVID-19 vaccine is contraindication second dose.ObjectiveTo assess outcomes associated with excipient skin testing after reported vaccine.MethodsWe identified consecutive sample patients reactions who underwent allergy assessment polyethylene glycol (PEG) and, when appropriate, polysorbate 80. Skin results in conjunction clinical phenotyping first-dose...
The immunogenicity and reactogenicity of SARS-CoV-2 vaccines in patients with cancer are poorly understood.We performed a prospective cohort study adults solid-organ or hematologic cancers to evaluate anti-SARS-CoV-2 immunoglobulin A/M/G spike antibodies, neutralization, ≥ 7 days following two doses mRNA-1273, BNT162b2, one dose Ad26.COV2.S. We analyzed responses by multivariate regression included data from 1,638 healthy controls, previously reported, for comparison.Between April July 2021,...
Glaucoma, the most frequent optic neuropathy, is a leading cause of blindness worldwide. Death retinal ganglion cells (RGCs) occurs in all forms glaucoma and accounts for loss vision, however molecular mechanisms that RGC remain unclear. The pro-apoptotic molecule, Fas ligand, transmembrane protein can be cleaved from cell surface by metalloproteinases to release soluble with antagonistic activity. Previous studies documented constitutive ocular expression FasL maintained immune privilege...
Large clinical trials have demonstrated the overall safety of vaccines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, reports emerged autoimmune phenomena, including vaccine-associated myocarditis, immune thrombocytopenia, and thrombotic thrombocytopenia.Here we present a novel case young woman who developed life-threatening hemolytic anemia (AIHA) after her first dose SARS-CoV-2 mRNA vaccine. Notably, initial direct antiglobulin testing was negative using...
The authors declare no conflicts of interest. Data sharing is not applicable to this article as new data were created or analyzed in study.
Abstract It has been proposed that the constitutive expression of Fas ligand (FasL) in eye maintains immune privilege, part through inducing apoptosis infiltrating Fas+ T cells. However, role FasL privilege remains controversial due to studies indicate is both pro- and anti-inflammatory. To elucidate mechanism(s) by which regulates we used an ocular tumor model examined individual roles membrane-bound soluble form regulating inflammation. Following injection into privileged eye, tumors...
Abstract A number of studies have documented a critical role for tumor-specific CD4+ cells in the augmentation immunotherapeutic effector mechanisms. However, context an extensive tumor burden, chronic stimulation such T often leads to up-regulation both Fas and ligand, coexpression these molecules can potentially result activation-induced cell death subsequent loss activity. To evaluate importance persistence experimental model immunotherapy, we used DO11 Th1 from wild-type, Fas-deficient,...
Abstract Fas ligand (FasL) can be either membrane bound, or cleaved by metalloproteinases (MMP) to produce a soluble protein. The two different forms of FasL are reported have opposite functions—membrane-bound (mFasL) is proinflammatory and (sFasL) antiinflammatory. We previously showed that, within the immune-privileged eye, tumors expressing high levels mFasL overcame suppressive ocular environment, triggered an inflammatory response, were subsequently rejected. By contrast, eye low grew...