A5100763424- Drug-Induced Adverse Reactions
- Inflammatory mediators and NSAID effects
- Animal Nutrition and Physiology
- Opioid Use Disorder Treatment
- Pharmacovigilance and Adverse Drug Reactions
- Pregnancy and Medication Impact
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Urticaria and Related Conditions
- Allergic Rhinitis and Sensitization
- Moringa oleifera research and applications
- Asthma and respiratory diseases
- SARS-CoV-2 and COVID-19 Research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Viral gastroenteritis research and epidemiology
- Contact Dermatitis and Allergies
- Cancer-related Molecular Pathways
- Chronic Lymphocytic Leukemia Research
- Advanced Breast Cancer Therapies
- Livestock and Poultry Management
- Trace Elements in Health
- Pain Management and Opioid Use
- Food Allergy and Anaphylaxis Research
- Cancer Treatment and Pharmacology
- Respiratory viral infections research
- Plant Pathogenic Bacteria Studies
Brigham and Women's Hospital
2019-2024
University of Washington
2024
Harvard University
2014-2023
KalVista Pharmaceuticals (United States)
2019-2022
BASF (United States)
2020
Eli Lilly (United States)
2011-2014
Harvard Pilgrim Health Care
2014
Cleveland Clinic Lerner College of Medicine
2012
Case Western Reserve University
2012
BackgroundThe Centers for Disease Control and Prevention state that a severe or immediate allergic reaction to the first dose of an mRNA COVID-19 vaccine is contraindication second dose.ObjectiveTo assess outcomes associated with excipient skin testing after reported vaccine.MethodsWe identified consecutive sample patients reactions who underwent allergy assessment polyethylene glycol (PEG) and, when appropriate, polysorbate 80. Skin results in conjunction clinical phenotyping first-dose...
Summary Beyond their essential function as the building blocks of proteins, amino acids contribute to many aspects plant biochemistry and physiology. Despite this, there are relatively large gaps in our understanding biochemical pathways regulation acid synthesis plants. A rapid (1.5 min versus 20–90 for standard methods) HPLC‐MS/MS assay separating 19 was developed quantifying levels free tissue. This used determine content seeds 10,000 randomly mutagenized Arabidopsis lines, 322 lines with...
The coloring efficiency and physiological function of astaxanthin in fish vary with its regions. aim this study was to compare the retention rates dietary from different sources effects on growth, pigmentation, Oncorhynchus mykiss. Fish were fed astaxanthin-supplemented diets (LP: 0.1% Lucantin® Pink CWD; CP: Carophyll® Pink; EP: Essention® PR: 1% Phaffia rhodozyma; HP: Haematococcus pluvialis), or a diet without supplementation, for 56 days. Dietary enhanced pigmentation as well growth...
Abstract LY2835219 is a novel cell cycle inhibitor selective for the cyclin-dependent kinases CDK4 and CDK6 (CDK4/6), which act in protein complex with D-type cyclins to enable G1 S progression. Preclinical models indicate this plays critical role breast cancer. We conducted phase I study expansion cohorts evaluate safety, pharmacokinetics, antitumor activity of 5 different tumor types: glioblastoma; melanoma; cancers lung, colon/rectum breast. In cohorts, was administered continuously at...
Background Patients with opioid use disorder (OUD) who are hospitalized for serious infections requiring prolonged intravenous antibiotics may face barriers to discharge, which could prolong hospital length of stay (LOS) and increase financial burden. We investigated differences in LOS, discharge disposition, charges between hospitalizations patients without OUD. Methods findings utilized the 2016 National Inpatient Sample—a nationally representative database all discharges from US acute...
<h3>Importance</h3> Allergic history in individuals with confirmed anaphylaxis to a messenger RNA (mRNA) COVID-19 vaccine is common. However, the risk factors for allergy symptoms after receiving are unknown. <h3>Objective</h3> To assess association between self-reported of high-risk and allergic reactions mRNA vaccination health care employees. <h3>Design, Setting, Participants</h3> This cohort study obtained demographic, medical, administration data employees Mass General Brigham from...
Hereditary angioedema (HAE) is a rare genetic disease that leads to recurrent episodes of swelling and pain caused by uncontrolled plasma kallikrein (PKa) activity. Current guidelines recommend ready availability on-demand HAE treatments can be administered early upon attack onset. This report describes the pharmacological pharmacodynamic properties novel oral small-molecule PKa inhibitor KVD900 as potential treatment for HAE.
Attacks of hereditary angioedema are attributed to excessive plasma kallikrein (PKa) activity, which cleaves high-molecular-weight kininogen generate the proinflammatory hormone bradykinin.We evaluated safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) KVD900, an orally administered inhibitor PKa in healthy adults.KVD900 was 2 clinical studies. In first study, adult men received single ascending doses (5-600 mg) KVD900 capsule or placebo, 100 mg tablet (crossover), 600 (6...
This study was conducted to investigate the effects of replacing inorganic trace minerals (ITM) with organic (OTM; complexed glycinates) on reproductive performance, blood profiles, and antioxidant status in broiler breeders. A total 648, 23-week-old healthy breeders (ZhenNing), similar body weight (1.40 ± 0.002 kg), were randomly divided into 4 groups 6 replicates each group (27 hens/replicate) fed respective experimental diets for 14 wk (including 2 adaptation). The treatments consisted...
Objectives Documentation of allergies in a coded, non–free-text format the electronic health record (EHR) triggers clinical decision support to prevent adverse events. Health system-wide patient safety initiatives improve EHR allergy documentation by specifically decreasing free-text entries have not been reported. The goal this initiative was systematically reduce allergen module. Methods We assessed commercial used at multihospital integrated care system greater Boston area. Using both...
The present study characterised the types and amounts of non-starch polysaccharides (NSP) remaining undigested along gastrointestinal tract (GIT) broiler chickens offered a typical wheat- or maize-based diet. One-day old Cobb 500 mixed-sex chicks were assigned to 24 pens, with 10 birds/pen 12 pens/treatment. Birds experimental diets in 3 phases (starter, day 0 10; grower, 11 finisher, 25 35). Excreta digesta samples from crop, gizzard, duodenum, jejunum, ileum caeca collected at 35 days age,...
The objective of this study was to evaluate the effect 2 different doses a partially buffered formic acid product (Amasil NA; 61% acid, 20.5% sodium formate), and monoglyceride blend short- medium-chain fatty acids (BalanGut LS P) on necrotic enteritis (NE) infected broilers in terms performance, intestinal microbial population short-chain concentrations gastrointestinal tract. A total 528-day-old as hatched Ross 308 were allocated 48 pens with 11 birds each pen. Six dietary treatments...
We compared the impact of 3 confounding adjustment procedures—covariate-adjusted regression, propensity score and high-dimensional regression—to assess effects selected asthma controller medication use (leukotriene antagonists inhaled corticosteroids) on following 4 asthma-related adverse outcomes: emergency department visits, hospitalizations, oral corticosteroid use, composite outcome these. examined a cohort 24,680 new users who were 4–17 years age at incident dispensing from...
This study evaluated the potential of monoglyceride blend (MG) and buffered formic acid (FA) as alternatives to antibiotics in performance intestinal health broilers under clinical necrotic enteritis (NE) challenge. A total 544 as-hatched Ross 308 broiler chicks were randomly distributed 32-floor pens housing 17 birds per pen. The four treatments were: NC-non-additive control; ZBS-antibiotic group supplemented with zinc bacitracin salinomycin; MG-additive MG supplementation starter phase...
This study was to characterise the undigested nutrients present along gastrointestinal tract of birds offered common wheat- or maize-based diets, with goal optimising utilisation enzymes enhance digestive efficiency. Wheat- and diets were 240 mixed-sex broilers (10 birds/pen; n = 12) from 1 35 d post-hatch. Digestibility dry matter, starch, crude protein non-starch polysaccharides (NSP) measured in crop, gizzard, duodenum, jejunum, ileum, caeca excreta at 12 Analysis nutrient levels...