A5078824760- Drug-Induced Adverse Reactions
- Urticaria and Related Conditions
- Food Allergy and Anaphylaxis Research
- Malaria Research and Control
- Copper-based nanomaterials and applications
- SARS-CoV-2 and COVID-19 Research
- Eosinophilic Disorders and Syndromes
- ZnO doping and properties
- Allergic Rhinitis and Sensitization
- Heparin-Induced Thrombocytopenia and Thrombosis
- Advanced Photocatalysis Techniques
- Evolution and Genetic Dynamics
- Vaccine Coverage and Hesitancy
- Microbial infections and disease research
- Contact Dermatitis and Allergies
- Advanced Nanomaterials in Catalysis
- Asthma and respiratory diseases
- Electronic and Structural Properties of Oxides
- Nanoparticles: synthesis and applications
- Pharmacovigilance and Adverse Drug Reactions
- Natural Fiber Reinforced Composites
- Advanced Cellulose Research Studies
- Genomics and Phylogenetic Studies
- Drug Transport and Resistance Mechanisms
- Graphene and Nanomaterials Applications
Wayamba University of Sri Lanka
2017-2025
Massachusetts General Hospital
2020-2024
Nationwide Children's Hospital
2023
Institute of Policy Studies of Sri Lanka
2023
University of Notre Dame
2011-2016
University of Nebraska–Lincoln
2012
The malaria parasite Plasmodium falciparum has a great capacity for evolutionary adaptation to evade host immunity and develop drug resistance. Current understanding of evolution is impeded by the fact that large fraction genome either highly repetitive or variable thus difficult analyze using short-read sequencing technologies. Here, we describe resource deep data on parents progeny from genetic crosses, which enabled us perform first genome-wide, integrated analysis SNP, indel complex...
BackgroundThe Centers for Disease Control and Prevention state that a severe or immediate allergic reaction to the first dose of an mRNA COVID-19 vaccine is contraindication second dose.ObjectiveTo assess outcomes associated with excipient skin testing after reported vaccine.MethodsWe identified consecutive sample patients reactions who underwent allergy assessment polyethylene glycol (PEG) and, when appropriate, polysorbate 80. Skin results in conjunction clinical phenotyping first-dose...
The release of dyes into normal water reservoirs has become a tremendous environmental problem and the development methods to remove such is essential. A novel photocatalyst was fabricated in which Cu doped TiO2 coupled with g-C3N4 (Cu-TiO2/g-C3N4) different weight percentages as 10, 30 50%, hydrothermally. Pure consisted both Anatase Rutile phases where slight lattice distortions were observed Cu-doped evidenced by XRD Raman analysis. present at 1.7% respective according XRF Spherical...
Introduction This study’s objective was to produce robust, comparable estimates of the prevalence diabetes and pre-diabetes in Sri Lankan adult population, where previous studies suggest highest South Asia. Research design methods We used data on 6661 adults from nationally representative 2018/2019 first wave Lanka Health Ageing Study (SLHAS). classified glycemic status based diagnosis, either fasting plasma glucose (FPG), or FPG 2-hour (2-h PG). estimated crude age-standardized by major...
Silver nanoparticles (AgNPs) are widely recognized as a prominent antimicrobial agent and have found applications in the field of medicine. This study focuses on synthesis AgNPs utilizing natural reducing Ceylon olive (Elaeocarpus serratus), presenting an economically viable ecologically friendly approach. For first time, this research demonstrated using phytochemicals extracted from olive, serving both stabilizing agents. The synthesized were characterized with UV–visible spectroscopy,...
Abstract Photocatalysts of TiO 2 –CuO coupled with 30% graphene oxide (GO) were hydrothermally fabricated, which varied the to CuO weight ratios 1:4, 1:2, 1:1, 2:1 and 4:1 reduced form –CuO/reduced (rGO) photocatalysts. They characterized using XRD, TEM, SEM, XPS, Raman, DRS technologies. composites –CuO/GO degrade methylene blue when persulfate ions are present. Persulfate concentration ranged from 1, 2, 4 8 mmol/dm −3 in highest activity 4.4 × 10 –2 7.35 min −1 was obtained for (1:4)...
The manufacture of composite materials reinforced with bristle fiber that possess distinct properties is highly attractive for novel applications. quality variations in coir fiber-reinforced rubber composites (CFRC) are mainly affected by several factors, including the type matrix used, interfacial adhesion between and matrix, length, loading. objectives this study were to assess characterise fibers extracted from diverse Sri Lankan coconut varieties identify high-quality suitable...
The manufacture of composite materials reinforced with bristle fiber that possess distinct properties is highly attractive for novel applications. quality variations in coir fiber-reinforced rubber composites (CFRC) are mainly affected by several factors, including the type matrix used, interfacial adhesion between and matrix, length, loading. objectives this study were to assess characterise fibers extracted from diverse Sri Lankan coconut varieties identify high-quality suitable...
Background Atherosclerotic cardiovascular diseases (ASCVD), including coronary artery disease (CAD), cerebrovascular (CVD), and peripheral vascular (PVD), remain the leading cause of death globally. South Asians exhibit a higher incidence than other ethnicities, attributed to range genetic, environmental, lifestyle factors. Lipoprotein(a) [Lp(a)] with unique apolipoprotein(a) component, has emerged as marker atherosclerosis ASCVD risk, evidence promote arterial plaque formation...
Plasmodium falciparum, the causative agent of severe human malaria, employs antigenic variation to avoid host immunity. Antigenic is achieved by transcriptional switching amongst polymorphic var genes, enforced epigenetic modification chromatin. The histone-modifying 'sirtuin' enzymes PfSir2a and PfSir2b have been implicated in this process. Disparate patterns expression reported patient isolates as well cultured strains. We examined three commonly used laboratory strains (3D7, NF54 FCR-3)...
<h3>Importance</h3> Allergic history in individuals with confirmed anaphylaxis to a messenger RNA (mRNA) COVID-19 vaccine is common. However, the risk factors for allergy symptoms after receiving are unknown. <h3>Objective</h3> To assess association between self-reported of high-risk and allergic reactions mRNA vaccination health care employees. <h3>Design, Setting, Participants</h3> This cohort study obtained demographic, medical, administration data employees Mass General Brigham from...
ABSTRACT The Cinchona alkaloids are quinoline aminoalcohols that occur as diastereomer pairs, typified by (−)-quinine and (+)-quinidine. potency of (+)-isomers is greater than the (−)-isomers in vitro vivo against Plasmodium falciparum malaria parasites. They may act inhibition heme crystallization within parasite digestive vacuole a manner similar to chloroquine. Earlier studies showed K76I mutation vacuole-associated protein, PfCRT ( P. chloroquine resistance transporter), reversed normal...
Copy number is a major source of genome variation with important evolutionary implications. Consequently, it essential to determine copy variant (CNV) behavior, distributions and frequencies across genomes understand their origins in both generational time frames. We use comparative genomic hybridization (CGH) microarray the resolution provided by segregating population cloned progeny lines malaria parasite, Plasmodium falciparum, identify analyze inheritance 170 genome-wide CNVs.We describe...
Abstract Background Knowledge of the origins, distribution, and inheritance variation in malaria parasite ( Plasmodium falciparum ) genome is crucial for understanding its evolution; however 81% (A+T) poses challenges to high-throughput sequencing technologies. We explore viability Roche 454 Genome Sequencer FLX (GS FLX) high throughput technology both whole fine-resolution characterization genetic exchange parasites. Results present a scheme survey recombination haploid stage genomes two...
The paradigm of resistance evolution to chemotherapeutic agents is that a key coding mutation in specific gene drives particular drug. In the case anti-malarial drug chloroquine (CQ), transporter pfcrt associated with resistance. Here, we apply series analytical steps expression data from our lab and leverage 3 independent datasets identify pfcrt-interacting genes. Resulting networks provide insights into pfcrt's biological functions regulation, as well divergent phenotypic effects its...