A5091742265- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Nitric Oxide and Endothelin Effects
- Cell Adhesion Molecules Research
- Cell death mechanisms and regulation
- Neurological Disorders and Treatments
- Bone health and treatments
- Artificial Intelligence in Healthcare and Education
- Colorectal Cancer Treatments and Studies
- COVID-19 Clinical Research Studies
- Angiogenesis and VEGF in Cancer
- Nutrition and Health in Aging
- Ophthalmology and Eye Disorders
- Medical Imaging and Pathology Studies
- Platelet Disorders and Treatments
- Radiopharmaceutical Chemistry and Applications
- Cancer Treatment and Pharmacology
- Anatomy and Medical Technology
- Long-Term Effects of COVID-19
- Nutritional Studies and Diet
- Surgical Simulation and Training
- CAR-T cell therapy research
- Antifungal resistance and susceptibility
- Cardiovascular Disease and Adiposity
Indiana University – Purdue University Indianapolis
2025
University College London
2015-2023
John Radcliffe Hospital
2023
University of Oxford
2020-2023
Massachusetts Eye and Ear Infirmary
2010-2016
Smith-Kettlewell Eye Research Institute
2011-2016
Duke University
2016
Harvard University
1988-2016
Vanderbilt Health
2006
Vanderbilt University
2006
Objectives To assess the communication potential of three-dimensional (3D) patient-specific models congenital heart defects and their acceptability in clinical practice for cardiology consultations. Design This was a questionnaire-based study which participants were randomised into two groups: ‘model group’ received 3D model cardiac lesion(s) being discussed during appointment, while ‘control had routine visit. Setting Outpatient clinic, follow-up visits. Participants 103 parents children...
Abstract Endomucin is a membrane-bound glycoprotein expressed luminally by endothelial cells that line postcapillary venules, primary site of leukocyte recruitment during inflammation. Here we show endomucin abrogation on quiescent enables neutrophils to adhere firmly, via LFA-1-mediated binding ICAM-1 constitutively cells. Moreover, TNF-α stimulation downregulates cell surface expression concurrent with increased adhesion molecules. Adenovirus-mediated under inflammatory conditions prevents...
Glaucoma, the most frequent optic neuropathy, is a leading cause of blindness worldwide. Death retinal ganglion cells (RGCs) occurs in all forms glaucoma and accounts for loss vision, however molecular mechanisms that RGC remain unclear. The pro-apoptotic molecule, Fas ligand, transmembrane protein can be cleaved from cell surface by metalloproteinases to release soluble with antagonistic activity. Previous studies documented constitutive ocular expression FasL maintained immune privilege...
Primary open angle glaucoma (POAG) is a leading cause of blindness worldwide. The molecular signaling involved in the pathogenesis POAG remains unknown. Here, we report that mice lacking α1 subunit nitric oxide receptor soluble guanylate cyclase represent novel and translatable animal model POAG, characterized by thinning retinal nerve fiber layer loss optic axons context an iridocorneal angle. neuropathy associated with α1–deficiency was accompanied modestly increased intraocular pressure...
Abstract Glaucoma is a multifactorial disease resulting in the death of retinal ganglion cells (RGCs) and irreversible blindness. Glaucoma-associated RGC depends on proapoptotic proinflammatory activity membrane-bound Fas ligand (mFasL). In contrast to mFasL, natural cleavage product, soluble (sFasL) inhibits mFasL-mediated apoptosis inflammation and, therefore, an mFasL antagonist. DBA/2J mice spontaneously develop glaucoma predictably, destruction exacerbated by expression mutated...
ABSTRACT Background Sarcopenia, the systemic loss of skeletal muscle mass and function, is prevalent particularly detrimental to head neck cancer (HNC) patients. Cancer‐associated sarcopenia involves complex mechanisms poor nutrition inflammation, highlighting necessity for preoperative identification these high‐risk Methods A multi‐site retrospective chart review (2016–2021) was performed on HNC patients undergoing total laryngectomy with or without reconstruction. Preoperative lab values...
Glaucoma is an optic neuropathy characterized by retinal ganglion cell degeneration leading to vision loss. Primary open angle glaucoma a subtype of that results in visual field loss due nerve damage caused increase intraocular pressure. Events primary (POAG) pathogenesis has been associated with nitric oxide (NO) which activates the soluble guanylate cyclase (sGC), heterodimeric enzyme consisting α and β subunits c GMP signaling. 1-2 In POAG patients NO metabolites level found be decreased...
Abstract Modifiable risk factors affect SARS-CoV-2 infection and mortality raising the possibility that lifestyle modification could play a role. This has not been studied at global level. We analysed publicly available data from countries reporting COVID-19 cases deaths. Associations of modifiable with total excess deaths were determined without adjustment for confounders. 4,670,832 311,384 reported by 181 18th May 2020. Wealthier had greatest caseload. Obesity was primary factor greater...
Background Greater body mass index is associated with cardiovascular remodeling in adolescents. However, cannot differentiate between adipose and nonadipose tissues. We examined how visceral subcutaneous tissue are linked markers of early remodeling, independently from tissue. Methods Results Whole-body magnetic resonance imaging was done 82 adolescents (39 overweight/obese; 36 female; median age, 16.3 [interquartile range, 14.4-18.1] years) to measure composition markers. Left ventricular...
Background.Candida krusei is the fifth most common Candida species recovered from clinical specimens in United States and worldwide.At Duke University Hospital it was responsible for ∼4 % (96/2560) of blood stream infections between 1992 2013, has increased to 6%-10% over past decade (2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013).C. intrinsically resistant fluconazole, emergence voriconazole resistance following exposure fluconazole a pressing concern.VT-1161...
Leukocyte‐endothelial cell (EC) interactions, including leukocyte rolling, adhesion and transmigration, are central to vascular inflammation. Endomucin‐1 (EMCN‐1) is a transmembrane glycoprotein specifically expressed by venous capillary endothelium. This study was aimed at determining the role of EMCN‐1 in regulating leukocyte‐EC interaction Whereas leukocytes do not adhere surface cultured human umbilical vein endothelial cells (HUVECs), transfection with siRNA against led dramatic...
Background Primary open angle glaucoma (POAG) is a progressive eye disease that leads to blindness due the irreversible loss of retinal ganglion cells and degeneration optic nerve (ON). As yet, there no cure for glaucoma. Although available therapies delay progression, they offer incomplete protection. Elevated intraocular pressure (IOP) an important risk factor POAG. However, exact molecular mechanisms trigger increased IOP glaucomatous neuropathy remain incompletely understood. While few...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)