A5039265393- Psoriasis: Treatment and Pathogenesis
- Tryptophan and brain disorders
- Health Systems, Economic Evaluations, Quality of Life
- Dermatology and Skin Diseases
- Treatment of Major Depression
- Multiple Sclerosis Research Studies
- Complementary and Alternative Medicine Studies
- Spondyloarthritis Studies and Treatments
- Pregnancy and Medication Impact
- Immunotherapy and Immune Responses
- COVID-19 Impact on Reproduction
- Lymphoma Diagnosis and Treatment
- Bipolar Disorder and Treatment
- Skin and Cellular Biology Research
- Interprofessional Education and Collaboration
- Blood Pressure and Hypertension Studies
- Assembly Line Balancing Optimization
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Internet Traffic Analysis and Secure E-voting
- Microscopic Colitis
- Pharmacogenetics and Drug Metabolism
- Risk and Portfolio Optimization
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- dental development and anomalies
Karolinska University Hospital
2018-2024
Karolinska Institutet
2018-2024
Umeå University
2013-2017
Beth Israel Deaconess Medical Center
1998-2005
Harvard University
1998-2005
Objectives Moderate to severe psoriasis, once regarded as merely a skin disease, is today seen an inflammatory systemic disease. The sex ratio of the prevalence psoriasis balanced. In recent years several reports have documented that men receive more or UV treatment than women, and different hypotheses were made. PsoReg, national registry for in Sweden, we have, like other European registries, observed predominance (59%), especially treated with biologics (63%). Biologics are relatively new...
We aimed to describe patterns of use and characteristics 10 commonly used antidepressants for the period 2009–2014 in Denmark, Germany, Spain, Sweden. Adult initiators from 2009 2014 each study antidepressant were identified four countries using five data sources: Danish National registers, GePaRD (Germany), EpiChron (Aragon, Spain), SIDIAP (Catalonia, Swedish Registers. The included antidepressants: citalopram, escitalopram, fluoxetine, paroxetine, sertraline, duloxetine, venlafaxine,...
Following the establishment of National Quality Registry for systemic psoriasis treatment (PsoReg), two outcome measurements, Psoriasis Area and Severity Index (PASI) Dermatology Life (DLQI), are now integrated in clinical practice Sweden. According to current guidelines, initiation a biological should depend on combination physician's patients' assessment disease impact health-related quality life measure (DLQI).To evaluate if either measures, PASI or DLQI, is more strongly associated with...
Aim: To estimate the prevalence of medication use in non-hospitalized pregnant women with COVID-19 Methods: A prospective two-stage individual patient meta-analysis across 10 data sources Europe and North America studied among between January 2020 to December 2022. Comparisons were made within 30 days pre- post-COVID-19 diagnosis this cohort two comparator groups: without COVID-19, non-pregnant COVID-19. Prevalence estimates pooled using a random-effects model stratified by trimester....
Agomelatine is a melatonin receptor agonist and serotonin 5-HT2C antagonist indicated for depression in adults. Hepatotoxic reactions like acute liver injury (ALI) are an identified risk the European management plan agomelatine. have been reported other antidepressants, but population studies quantifying these risks scarce. Antidepressants widely prescribed, users often factors ALI (e.g. metabolic syndrome). The goal was to estimate of associated with agomelatine antidepressants (fluoxetine,...
Background Several definitions of treatment-resistant depression (TRD) are used for clinical research, but no verified model use in register data exists. We aimed to compare a novel created data—the Karolinska Institutet Model (KIM)–to the regarding proportion patients identified with TRD, their characteristics and outcomes. Methods All Sweden initiating antidepressant treatment diagnosis specialized healthcare 2006–2014 were followed national registers. In KIM, who initiated third...
Abstract Background It has been repeatedly shown that men infected by SARS-CoV-2 face a twofold higher likelihood of dying, being hospitalized or admitted to the intensive care unit compared women, despite taking into account relevant confounders. hypothesized these discrepancies are related sex steroid hormone differences with estrogens negatively correlated disease severity. The objective this study was therefore evaluate COVID-19-related mortality and morbidity among peri- postmenopausal...
Psoriasis is an immune-mediated chronic inflammatory disease having a significant negative health impact. has societal impact; loss of productivity been estimated at approximately 10% and it may influence the patient's financial status. Relationships between quality life, severity, cost care need exploration. Understanding burden important for policy research allocation. Few studies address gaps in socioeconomics, comorbidity, medication use.Observing differences education, income,...
To investigate whether the association between depression and inflammatory joint disease (IJD; rheumatoid arthritis [RA], psoriatic [PsA], ankylosing spondylitis/spondyloarthropathies [AS], juvenile idiopathic [JIA]) is affected by severity or treatment-resistance of depression. Parallel cohort studies case-control among 600,404 patients with a depressive episode identified in Swedish nationwide administrative registers. Prospective retrospective risk for IJD was compared to matched...
Background: Association between psoriasis severity and cerebro- cardiovascular comorbidities has rarely been investigated. Aim: We aimed to investigate differences in by severity. Materials methods: Using Swedish nationwide health-care registers, new adult users of anti-psoriatic drugs (2007–2013) with a recorded diagnosis psoriasis/psoriatic arthritis or filled prescription for calcipotriol were included. Psoriasis was based on the type treatment (topical/mild, non-biologic...
Mutations in the EDAR-gene cause hypohidrotic ectodermal dysplasia with defects appendage development including teeth, skin, exocrine glands and hair. Hair are sparsely described genetically defined samples. The aim of this study was to investigate hair structures three families a heterozygous c.1072C > T mutation EDAR gene using scanning electron microscopy.Three Swedish families, where some members had known an autosomal dominant inheritance (AD) were included (n = 37) which 17 carried 20...
To assess the relative risk of metabolic factors in patients stratified by psoriasis severity compared with population controls.A retrospective cohort study was conducted using national Swedish registers. Adult were selected if they had a dispensing anti-psoriasis prescription (2007-2013) and at least one diagnosis within five years before date. The matched 1:10 to controls from general on birth year, sex, county. further divided into three disease groups (mild, moderate, or severe) based...
To investigate the health care utilisation (HCU) among patients with treatment-resistant depression (TRD) compared to not meeting TRD criteria.Nationwide Swedish registers were used identify 18-69 years old incident and antidepressant treatment. Patients followed prospectively defined as having at start of third distinct consecutive treatment episode. Each 16,329 identified matched five comparators criteria for TRD. Main outcome measure was total number inpatient days outpatient visits,...
This study aimed to estimate risks of cardiovascular and cerebrovascular events in patients treated with lisdexamfetamine dimesylate (LDX) compared previously other attention-deficit/hyperactivity disorder (ADHD) medications (amphetamine, dexamphetamine, methylphenidate or atomoxetine).This population-based cohort used data from Danish Swedish medical administrative national registers. The LDX included adult initiating at least 12 months' preceding first dispensing (index date). A random...
Introduction Safe and effective pharmacological treatment is of paramount importance for treating severe psoriasis. Brodalumab, a monoclonal antibody against interleukin (IL) 17 receptor A, was granted marketing authorisation in the EU 2017. The European Medicines Agency requested postauthorisation safety study brodalumab to address potential issues raised during drug development regarding major adverse cardiovascular events, suicidal conduct, cancer serious infections. Methods analysis...
Objective: To investigate whether the association between depression and inflammatory joint disease (IJD; rheumatoid arthritis [RA], psoriatic [PsA], ankylosing spondylitis/spondyloarthropathies [AS], juvenile idiopathic [JIA]) is affected by severity or treatment-resistance of depression.Method: Parallel cohort studies case-control among 600,404 patients with a depressive episode identified in Swedish nationwide administrative registers. Prospective retrospective risk for IJD was compared...