A5007122786- Platelet Disorders and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Atrial Fibrillation Management and Outcomes
- Blood groups and transfusion
- Venous Thromboembolism Diagnosis and Management
- Diabetes Treatment and Management
- Urinary Bladder and Prostate Research
- Metabolism, Diabetes, and Cancer
- Dermatology and Skin Diseases
- Bladder and Urothelial Cancer Treatments
- Cardiac Arrhythmias and Treatments
- Advanced Causal Inference Techniques
- Psoriasis: Treatment and Pathogenesis
- Spectroscopy and Chemometric Analyses
- Antiplatelet Therapy and Cardiovascular Diseases
- Autoimmune Bullous Skin Diseases
- Asthma and respiratory diseases
- Statistical Methods in Clinical Trials
- Urinary Tract Infections Management
- Urologic and reproductive health conditions
- Chronic Lymphocytic Leukemia Research
- Reproductive System and Pregnancy
- Sexual function and dysfunction studies
- Respiratory viral infections research
- COVID-19 and healthcare impacts
Karolinska Institutet
2016-2025
University of Rochester
2023-2025
Karolinska University Hospital
2014-2024
Community Link
2022
Pharmac
2014
Bürgerhospital Frankfurt am Main
2012
Justus-Liebig-Universität Gießen
2010
Universitäres Zentrum für Zahnmedizin Basel
2008
AstraZeneca (United Kingdom)
2006
Charité - Universitätsmedizin Berlin
2005
BackgroundUlcerative colitis (UC) and Crohn's disease (CD) have been associated with increased risks of adverse birth outcomes. Disease activity drug exposure may contribute to the association.
Background Numerous case reports about drug-induced (DI) subacute cutaneous lupus erythematosus (SCLE) have been published. Various drug types with different latencies has proposed as triggers for this autoimmune skin disease. Objectives To evaluate the association between exposure to certain suspected drugs (previously implicated induce SCLE) and a subsequent diagnosis of SCLE. Methods We performed population-based matched case–control study in which all incident cases SCLE (n = 234) from...
<b>Objective</b> To evaluate the association between pioglitazone use and bladder cancer risk in patients with type 2 diabetes. <b>Design</b> Retrospective cohort study using propensity score matched cohorts. <b>Settings</b> Healthcare databases from Finland, Netherlands, Sweden, United Kingdom. Data comprised country specific datasets of linked records on prescriptions, hospitals, general practitioners, cancer, deaths. <b>Participants</b> Patients diabetes who initiated...
Abstract We consider calibration of hyphenated instruments with particular focus on determination the unknown concentrations new specimens. A instrument generates for each specimen a two‐way array data. These are assumed to depend through bilinear regression model, where constituent is characterized by pair profiles be determined in calibration. discuss problem predicting specimen, after formulate three different predictor construction methods, ‘naive’ method, least squares and refined...
Abstract Purpose To investigate risk factors for severe bleeding during warfarin treatment, including the influence of sex, age, comorbidity and co-medication on risk. Methods Patients initiating treatment between 2007 2011 were identified in nationwide Swedish Prescribed Drug Register, diagnoses retrieved from National Patient Register. Hazard ratios (HR) with 95% confidence intervals (CI) estimated using multiple Cox regression adjusting indications covariates comorbidities co-medications....
Earlier studies, mainly prior to the widespread use of advanced therapy and implementation guidelines for thromboprophylaxis indicate a doubled risk venous thromboembolism (VTE) in patients with inflammatory bowel disease (IBD). Using Swedish healthcare registers, we identified population-based cohort incident IBD 2007-2021. Patients were matched by age, sex, calendar year birth place residence up 10 reference individuals. The primary outcome was VTE, i.e., pulmonary embolism (PE) deep vein...
Objectives Describe and compare the risk of cardiovascular non-cardiovascular mortality in patients whose antidiabetic therapy is modified to include pioglitazone compared with an alternative medication at same stage disease progression. Research design methods This exploratory linked database cohort analysis used pooled health data from three European countries: Finland, Sweden UK. Propensity score together exact matching was match 31 133 type 2 diabetes first prescribed 2000 2011, never...
Highlights•7225 patients from France and 2490 Sweden with primary ITP have similar incidence rates of AT VTE.•Comorbidities present at baseline increase the risk both VTE.•Age, male sex a previous are most important factors for in this patient group.•Age cancer strongest VTE.AbstractBackgroundPrevious studies found that Immune thrombocytopenia (ITP) an increased arterial thrombosis (AT) venous thromboembolism (VTE). However, adults remain unassessed large cohorts.AimTo assess occurrence...
<b><i>Background/Aim:</i></b> High-dose oestrogen treatment has been used to reduce growth in tall adolescent girls. The long-term safety with regard cancer not clarified. Our aim was study if this reduction therapy affects risk later life. <b><i>Methods:</i></b> A cohort of 369 (172 treated, 197 untreated) Swedish women who 1973-1993 were assessed for stature designed. Data collected from university hospital records, patient questionnaires,...
Summary We aimed to assess the risk factors of venous thrombosis (VT) and arterial (AT) in adults with primary immune thrombocytopenia (ITP), particularly relation treatments. The population comprised all incident ITP France between 2009 2017 (FAITH cohort; NCT03429660) built national health database. Outcomes were first hospitalisation for VT AT. Multivariable Cox regression models included baseline factors, time‐varying exposure drugs, splenectomy cardiovascular drugs. cohort 10 039...
Estimate and compare the risk of mortality in patients whose antidiabetic therapy is modified to include pioglitazone compared with an alternative medication at same stage disease progression.Retrospective cohort study.Pooled analysis clinical data collected from primary and/or secondary care settings four European countries: Finland, The Netherlands, Sweden UK .56 337 type 2 diabetes mellitus first prescribed between 2000 2011, 56 never matched by treatment stage, history diabetes,...
Purpose To describe the use of antimuscarinic drugs to treat overactive bladder (OAB) in Denmark, Sweden, and United Kingdom (UK). Methods We identified new users darifenacin, fesoterodine, oxybutynin, solifenacin, tolterodine, trospium aged 18 years or older from Danish National Registers (2004–2012), Swedish (2006–2012), UK Clinical Practice Research Datalink (2004–2012). Users were followed until disenrollment, cancer diagnosis, death, study end. Treatment episodes, by linking consecutive...
Abstract Purpose To assess the impact on exposure time and outcome misclassifications, consequent exposure-outcome associations from treatment episode construction. We investigated dosage assumptions of 1 unit per day, DDD versus actual prescribed under different handling gaps overlaps prescriptions. Methods Data mirtazapine citalopram (years 2006–2014) Swedish Prescribed Drug register were used. Via a within individuals design we compared method A, based dosage, with methods B C drug day...
Background Previous studies have indicated that taller individuals are at greater risk of developing cancer. Death from cancer and other specific causes also been linked to height, but the results inconclusive. We aimed shed further light on associations between incidence mortality. Methods conducted a nationwide, population-based prospective cohort study, including 5.5 million Swedish women men (aged 20–74). They were followed over period up 54 years. Heights retrieved national registers...
The risk of cardiac adverse events following clozapine use is debated and unknown for the chemically related widely used antipsychotics olanzapine quetiapine. National Swedish registers were to identify all patients 16-75 years old with antipsychotic dispensations between 2005 2018. short-term outcome was a diagnosis perimyocarditis (pericarditis and/or myocarditis) within two months first dispensation, long-term heart failure (including cardiomyopathy) three years. Cox regressions time...