A5101498753- COVID-19 Clinical Research Studies
- Protease and Inhibitor Mechanisms
- COVID-19 and healthcare impacts
- Cancer Immunotherapy and Biomarkers
- Transplantation: Methods and Outcomes
- Atherosclerosis and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- SARS-CoV-2 and COVID-19 Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Ultrasound in Clinical Applications
- Galectins and Cancer Biology
- Chemotherapy-induced cardiotoxicity and mitigation
- Metabolism, Diabetes, and Cancer
- Long-Term Effects of COVID-19
- S100 Proteins and Annexins
- Diabetic Foot Ulcer Assessment and Management
- Cardiovascular Disease and Adiposity
- Cardiac Fibrosis and Remodeling
- Nitric Oxide and Endothelin Effects
- Sepsis Diagnosis and Treatment
- Receptor Mechanisms and Signaling
- Complement system in diseases
- Healthcare Systems and Public Health
- Intensive Care Unit Cognitive Disorders
- Renal Transplantation Outcomes and Treatments
The University of Texas Medical Branch at Galveston
2024-2025
University of Michigan
2022-2024
Michigan United
2024
Michigan Medicine
2023-2024
Orlando Health
2023
Saint Joseph University
2021-2022
Abstract Severe coronavirus disease 2019 (COVID‐19) is a hyperinflammatory syndrome. The biomarkers of inflammation best suited to triage patients with COVID‐19 are unknown. We conducted prospective multicenter observational study adult hospitalized specifically for from February 1, 2020 October 19, 2022. Biomarkers measured included soluble urokinase plasminogen activator receptor (suPAR), C‐reactive protein, interleukin‐6, procalcitonin, ferritin, and D‐dimer. In‐hospital outcomes examined...
To evaluate the impact of intubation timing, guided by severity criteria, on mortality in critically ill COVID-19 patients, amidst existing uncertainties regarding optimal practices.
Obesity is a risk factor for coronavirus disease 2019 (COVID-19)-related outcomes; however, the mechanism remains unclear. The objective of this analysis was to determine whether inflammation mediates association between obesity and COVID-19 outcomes. International Study Inflammation in (ISIC): A Prospective Multi-Center Observational Examining Role Biomarkers Predicting Covid-19 Related Outcomes Hospitalized Patients, conducted at 10 hospitals United States Europe. Participants were adults...
Elevation in soluble urokinase receptor (suPAR) and proteinuria are common signs patients with moderate to severe coronavirus disease 2019 (COVID-19). Here we characterize a new type of originating as part viral response. Inoculation acute respiratory syndrome 2 (SARS-CoV-2) causes increased suPAR levels glomerulopathy African green monkeys. Using an engineered mouse model high expression, inhaled variants SARS-CoV-2 spike S1 protein elicite that could be blocked by either antibody or...
Background: Use of hematopoietic stem cell transplantation (HSCT) continues to rise in the United States, particularly older age groups; however, HSCT is associated with various cardiovascular complications including heart failure (HF). We sought examine whether prolonged QTc prior was risk HF post-HSCT. Methods: used data from Cardiovascular Registry Bone Marrow Transplantation (CARE-BMT) study, a multicenter observational study adult patients (aged ≥18 years) who underwent...
Introduction: Hematopoietic stem cell transplantation (HSCT) is associated with adverse cardiovascular (CV) events including the development of heart failure (HF) and arrythmias. While transthoracic echocardiogram (TTE) routinely obtained prior to HSCT, its role in predicting incidence HSCT related CV poorly understood. Methods: We used data from Cardiovascular Registry Bone Marrow Transplantation (CARE-BMT) study, a multicenter observational study adult patients (aged ≥18 years) who...
Introduction: Statins are lipid-lowering agents with anti-inflammatory effects. Data surrounding the benefits of statins in patients coronavirus disease 2019 (Covid-19) conflicting. We sought to better understand impact context Covid-19-related inflammation. Methods: leveraged International Study Inflammation Covid-19, a prospective multicenter cohort study hospitalized specifically for Covid-19 between February 1, 2020 and October 30, 2022. Participants underwent systematic assessment...
Cardiac aging is characterized by progressive fibrosis. Epidemiological studies have found that advanced paternal age associated with an increased risk of heart failure in the next generation. This study aimed at evaluating effect age, young male rat progeny, on cardiac phenotype under circulatory stress conditions. Offspring rats were obtained mating old males (24 months old) females (two and same females. Hypertension was induced father offspring (OFO) (YFO) using L-NAME...
Abstract In patients with moderate to severe coronavirus disease 2019 (COVID-19), both proteinuria and high plasma levels of soluble urokinase receptor (suPAR) are commonly observed. Here we show a new type originating as part viral response. Inoculation acute respiratory syndrome 2 (SARS-CoV-2) caused increased suPAR glomerulopathy in African Green Monkeys. We developed unique mouse model whereby inhaled variants the SARS-CoV-2 spike S1 protein elicited suPAR. This proteinuric response was...
Chronic inflammation is a hallmark of type 2 diabetes (T2D) and driver its complications. Soluble urokinase plasminogen activator receptor (suPAR) an immune-derived signaling glycoprotein involved in the pathogenesis diabetes-related outcomes, notably atherosclerosis nephropathy. We aimed to determine if optimal medical therapy, insulin sensitization, revascularization strategy impact suPAR levels modulate association with outcomes. leveraged Bypass Angioplasty Revascularization...
<b>Introduction:</b> Non-contrast non-gated computed tomography (NCCT) is routinely performed in hospitalized Covid-19 patients to assess lung involvement. Assessment of pulmonary artery diameter (PAD) can be easily obtained from NCCT. We hypothesized that baseline PAD measurement, reflecting right ventricular strain, could related outcomes. <b>Methods:</b> From the authors' institutional Hotel Dieu de France university hospital (Beirut, Lebanon) database, was measured on Various outcomes...