A5034047007- COVID-19 Clinical Research Studies
- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Protease and Inhibitor Mechanisms
- COVID-19 and healthcare impacts
- Long-Term Effects of COVID-19
- Atherosclerosis and Cardiovascular Diseases
- Cholesterol and Lipid Metabolism
- Autophagy in Disease and Therapy
- Retinal Imaging and Analysis
- Advanced Glycation End Products research
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Biochemical and Molecular Research
- Nutritional Studies and Diet
- S100 Proteins and Annexins
- Healthcare Systems and Public Health
- Molecular Communication and Nanonetworks
- SARS-CoV-2 and COVID-19 Research
- Virus-based gene therapy research
- Metabolism, Diabetes, and Cancer
- Renal Diseases and Glomerulopathies
- Diabetes Management and Research
- Lipoproteins and Cardiovascular Health
- Neuroscience and Neural Engineering
University of Michigan–Ann Arbor
2016-2024
Michigan Medicine
2018-2024
Orlando Health
2023
Michigan United
2016-2021
W.K. Kellogg Foundation
2017-2021
Visual Sciences (United States)
2017
Abstract Severe coronavirus disease 2019 (COVID‐19) is a hyperinflammatory syndrome. The biomarkers of inflammation best suited to triage patients with COVID‐19 are unknown. We conducted prospective multicenter observational study adult hospitalized specifically for from February 1, 2020 October 19, 2022. Biomarkers measured included soluble urokinase plasminogen activator receptor (suPAR), C‐reactive protein, interleukin‐6, procalcitonin, ferritin, and D‐dimer. In‐hospital outcomes examined...
To evaluate the impact of intubation timing, guided by severity criteria, on mortality in critically ill COVID-19 patients, amidst existing uncertainties regarding optimal practices.
Dry age-related macular degeneration (AMD) is marked by the accumulation of extracellular and intracellular lipid-rich deposits within around retinal pigment epithelium (RPE). Inducing autophagy, a conserved, degradative pathway, potential treatment strategy to prevent disease clearing these deposits. However, mTOR inhibition, major mechanism for inducing disrupts core RPE functions. Here, we screened autophagy inducers that do not directly inhibit their as an AMD therapeutic in primary...
Obesity is a risk factor for coronavirus disease 2019 (COVID-19)-related outcomes; however, the mechanism remains unclear. The objective of this analysis was to determine whether inflammation mediates association between obesity and COVID-19 outcomes. International Study Inflammation in (ISIC): A Prospective Multi-Center Observational Examining Role Biomarkers Predicting Covid-19 Related Outcomes Hospitalized Patients, conducted at 10 hospitals United States Europe. Participants were adults...
Purpose: The accumulation of undigestible autofluorescent material (UAM), termed lipofuscin in vivo, is a hallmark aged RPE. Lipofuscin derives, part, from the incomplete degradation phagocytized photoreceptor outer segments (OS). Whether this accumulated waste toxic unclear. We therefore investigated effects UAM highly differentiated human fetal RPE (hfRPE) cultures. Methods: Unmodified and photo-oxidized OS were fed daily to confluent cultures ARPE-19 or hfRPE. emission spectrum,...
Early-onset severe retinal dystrophy (EOSRD) is a genetically heterogeneous group of diseases resulting in serious visual disability children. A significant number EOSRD cases, often diagnosed as Leber congenital amaurosis (LCA13), are associated with mutations the gene encoding retinol dehydrogenase 12 (RDH12). RDH12 member enzyme family short-chain dehydrogenases/reductases. In retina, plays critical role reducing toxic retinaldehydes generated by cycle activity that required for light...
Elevation in soluble urokinase receptor (suPAR) and proteinuria are common signs patients with moderate to severe coronavirus disease 2019 (COVID-19). Here we characterize a new type of originating as part viral response. Inoculation acute respiratory syndrome 2 (SARS-CoV-2) causes increased suPAR levels glomerulopathy African green monkeys. Using an engineered mouse model high expression, inhaled variants SARS-CoV-2 spike S1 protein elicite that could be blocked by either antibody or...
Chronic inflammation is a hallmark of type 2 diabetes (T2D) and driver its complications. Soluble urokinase plasminogen activator receptor (suPAR) an immune-derived signaling glycoprotein involved in the pathogenesis diabetes-related outcomes, notably atherosclerosis nephropathy. We aimed to determine if optimal medical therapy, insulin sensitization, revascularization strategy impact suPAR levels modulate association with outcomes. leveraged Bypass Angioplasty Revascularization...