A5056157307- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Liver Disease Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- COVID-19 and healthcare impacts
- Sepsis Diagnosis and Treatment
- Cancer Cells and Metastasis
- Respiratory Support and Mechanisms
- Signaling Pathways in Disease
- COVID-19 Impact on Reproduction
- Liver physiology and pathology
- Diabetes and associated disorders
- Cardiac Arrest and Resuscitation
- Ovarian cancer diagnosis and treatment
- Microtubule and mitosis dynamics
- Acute Kidney Injury Research
- Heat shock proteins research
- Inflammatory mediators and NSAID effects
- Retinal Development and Disorders
- Cancer, Stress, Anesthesia, and Immune Response
- Muscle and Compartmental Disorders
- Glutathione Transferases and Polymorphisms
- Intensive Care Unit Cognitive Disorders
- Venous Thromboembolism Diagnosis and Management
- Diverse Scientific Research Studies
University of Michigan–Ann Arbor
2016-2024
University of Thessaly
2020-2022
Heinrich Heine University Düsseldorf
2020-2022
Düsseldorf University Hospital
2020-2022
University General Hospital Attikon
2020-2022
Rush University
2022
Hvidovre Hospital
2022
Charité - Universitätsmedizin Berlin
2022
Copenhagen University Hospital
2022
Michigan Medicine
2019
Abstract Objectives To estimate the incidence, risk factors, and outcomes associated with in-hospital cardiac arrest cardiopulmonary resuscitation in critically ill adults coronavirus disease 2019 (covid-19). Design Multicenter cohort study. Setting Intensive care units at 68 geographically diverse hospitals across United States. Participants Critically (age ≥18 years) laboratory confirmed covid-19. Main outcome measures In-hospital within 14 days of admission to an intensive unit mortality....
Intense light exposure causes photoreceptor apoptosis in dark-adapted adult albino zebrafish ( Danio rerio ). Subsequently, Müller glia increase expression of the Achaete-scute complex-like 1a (Ascl1a) and Signal transducer activator transcription 3 (Stat3) factors re-enter cell cycle to yield undifferentiated neuronal progenitors that continue proliferate, migrate outer nuclear layer, differentiate into photoreceptors. A proteomic analysis light-damaged retinal homogenates, which induced...
Significance Statement Nearly half of hospitalized patients with coronavirus disease 2019 (COVID-19) develop AKI, 20% requiring dialysis. High levels soluble urokinase plasminogen activator receptor (suPAR)—an immune mediator kidney injury—predispose to AKI in various clinical scenarios, including critical illness. suPAR modulate mitochondrial respiration and induce the generation reactive oxygen species proximal tubular cells, sensitizing them additional insults. In a multicenter...
OBJECTIVE Diabetes mellitus (DM) is a major risk factor for severe coronavirus disease 2019 (COVID-19) reasons that are unclear. RESEARCH DESIGN AND METHODS We leveraged the International Study of Inflammation in COVID-19 (ISIC), multicenter observational study 2,044 patients hospitalized with COVID-19, to characterize impact DM on in-hospital outcomes and assess contribution inflammation hyperglycemia attributed DM. measured biomarkers collected at hospital admission glucose levels insulin...
Abstract Severe coronavirus disease 2019 (COVID‐19) is a hyperinflammatory syndrome. The biomarkers of inflammation best suited to triage patients with COVID‐19 are unknown. We conducted prospective multicenter observational study adult hospitalized specifically for from February 1, 2020 October 19, 2022. Biomarkers measured included soluble urokinase plasminogen activator receptor (suPAR), C‐reactive protein, interleukin‐6, procalcitonin, ferritin, and D‐dimer. In‐hospital outcomes examined...
Little is known about the factors that regulate asymmetric division of cancer stem-like cells (CSC). Here, we demonstrate EGFL6, a stem cell regulatory factor expressed in ovarian tumor and vasculature, regulates ALDH+ CSC. EGFL6 signaled at least part via oncoprotein SHP2 with concomitant activation ERK. signaling promoted migration As such, increased not only growth but also metastasis. Silencing or limited numbers reduced growth, supporting critical role for EGFL6/SHP2 maintenance....
// Mangala Iyengar 1, 2, * , Patrick O’Hayer Alex Cole 4 Tara Sebastian 3 Kun Yang Lan Coffman 4, # and Ronald J. Buckanovich 5, 1 University of Michigan, Department Cellular Molecular Biology, Ann Arbor, MI 48109, USA 2 Medical Scientist Training Program, School Literature, Science the Arts, Division Hematology Oncology, Internal Medicine, 5 Magee Women’s Research Institute, Pittsburgh, PA 15213, Co-first authors Co-senior Correspondence to: Buckanovich, email:...
Development of chemotherapy resistance is a major problem in ovarian cancer. One understudied mechanism chemoresistance the induction quiescence, reversible nonproliferative state. Unfortunately, little known about regulators quiescence. Here, we identify master transcription factor nuclear activated T cells cytoplasmic 4 (NFATC4) as regulator quiescence NFATC4 enriched cancer stem-like and correlates with decreased proliferation poor prognosis. Treatment cisplatin resulted translocation...
Background: Preexisting cardiovascular disease (CVD) is perceived as a risk factor for poor outcomes in patients with COVID-19. We sought to determine whether CVD associated in-hospital death and events critically ill Methods: This study used data from multicenter cohort of adults laboratory-confirmed COVID-19 admitted intensive care units at 68 centers across the United States March 1 July 1, 2020. The primary exposure was CVD, defined preexisting coronary artery disease, congestive heart...
Background Use of angiotensin‐converting enzyme inhibitors and angiotensin receptor blockers (ACEi/ARB) is thought to affect COVID‐19 through modulating levels 2, the cell entry for SARS‐CoV2. We sought assess association between ACEi/ARB, biomarkers inflammation, outcomes in patients hospitalized COVID‐19. Methods Results leveraged ISIC (International Study Inflammation COVID‐19), identified admitted symptomatic February 1, 2020 June 2021 COVID‐19, examined in‐hospital ACEi/ARB use...
Background Venous thromboembolism (VTE) contributes significantly to COVID-19 morbidity and mortality. The urokinase receptor system is involved in the regulation of coagulation. Levels soluble plasminogen activator (suPAR) reflect hyperinflammation are strongly predictive outcomes COVID-19. Whether suPAR levels identify patients with at risk for VTE unclear. Methods Results We leveraged a multinational observational study hospitalized D-dimer measured on admission. In 1960 (mean age, 58...
// Alexander T. Pearson 1 , Patrick Ingram 2 Shoumei Bai 3 O'Hayer 4 Jaehoon Chung 5 Euisik Yoon 6 Trachette Jackson 7, * and Ronald J. Buckanovich 3, Section of Hematology/Oncology, Department Medicine, University Chicago, IL, USA Biomedical Engineering, Wisconsin, Madison, WI, Magee-Womens Research Institute, Pittsburgh, PA, Michigan School Ann Arbor, Michigan, MI, Institute Microelectronics, Science Engineering Council the Agency for Science, Technology Research, Singapore Electrical...
<b>Objective: </b>Diabetes mellitus (DM) is a major risk factor for severe coronavirus disease 2019 (COVID-19) reasons that are unclear. <p><b>Research Design and Methods: </b>We leveraged The International Study of Inflammation in COVID-19, multicenter observational study 2,044 patients hospitalized with to characterize the impact DM on in-hospital outcomes assess contribution inflammation hyperglycemia attributed DM. We measured biomarkers collected at...
Abstract Development of chemotherapy resistance is a major problem in ovarian cancer. One understudied mechanism chemoresistance the induction quiescence, reversible non-proliferative state. Unfortunately, little known about regulators quiescence. Here we identify master transcription factor NFATC4 as regulator quiescence enriched cancer stem-like cells (CSC) and correlates with decreased proliferation poor prognosis. Treatment cisplatin results nuclear translocation activation pathway,...
Background: Secondary infections occur in 10-15% of critically ill sepsis patients. Anecdotal reports suggest secondary are common coronavirus disease 2019 (COVID-19), however data lacking. We examine the rate hospitalized patients with COVID-19 and its impact on cytokine surge in-hospital outcomes. Methods: The Michigan Medicine Covid-19 Cohort (M2C2) is an ongoing prospective observational study which detailed clinical, laboratory outcome were collected from chart review consecutive adult...
Introduction: The COVID-19 pandemic has spread across the globe and claimed many lives. Initial studies suggest that there are gender-based differences in severity of disease mortality, with male patients having worse outcomes. We sought to further characterize gender infection. Hypothesis: Male have a higher illness from COVID-19. Methods: Michigan Medicine Cohort (M2C2) is an ongoing prospective observational study which detailed clinical, laboratory outcomes data were collected chart...
<div>Abstract<p>Little is known about the factors that regulate asymmetric division of cancer stem–like cells (CSC). Here, we demonstrate EGFL6, a stem cell regulatory factor expressed in ovarian tumor and vasculature, regulates ALDH<sup>+</sup> CSC. EGFL6 signaled at least part via oncoprotein SHP2 with concomitant activation ERK. signaling promoted migration As such, increased not only growth but also metastasis. Silencing or limited numbers reduced growth,...