A5041468264- SARS-CoV-2 and COVID-19 Research
- Cancer Immunotherapy and Biomarkers
- COVID-19 Clinical Research Studies
- Extracellular vesicles in disease
- CRISPR and Genetic Engineering
- Immune cells in cancer
- Cystic Fibrosis Research Advances
- Genetics, Aging, and Longevity in Model Organisms
- Dermatological and COVID-19 studies
- Telomeres, Telomerase, and Senescence
- Long-Term Effects of COVID-19
- Adenosine and Purinergic Signaling
- Inhalation and Respiratory Drug Delivery
- Immune Cell Function and Interaction
- Neonatal Respiratory Health Research
Concept Life Sciences (United Kingdom)
2025
Centre for Inflammation Research
2020-2021
University of Edinburgh
2020-2021
Queen's Medical Centre
2020-2021
Istituto di Genetica Molecolare
2019-2021
Medical Research Council
2020
In life-threatening coronavirus disease (COVID-19), corticosteroids reduce mortality, suggesting that immune responses have a causal role in death. Whether this deleterious inflammation is primarily direct reaction to the presence of severe acute respiratory syndrome 2 (SARS-CoV-2) or an independent immunopathologic process unknown.
Bone metastasis is the major cause of death in breast cancer. The lack effective treatment suggests that disease mechanisms are still largely unknown. As a key component tumor microenvironment, macrophages promote progression and metastasis. In this study, we found abundant human mouse cancer bone metastases. Macrophage ablation significantly inhibited growth. Lineage tracking experiments indicated these derive from Ly6C+CCR2+ inflammatory monocytes. Ablation chemokine receptor, CCR2,...
ABSTRACT Background Tissue inflammation is associated with organ dysfunction and death in Covid-19. The efficacy of dexamethasone preventing mortality critical Covid-19 suggests that has a causal role death. Whether this deleterious direct response to the presence SARS-CoV-2, or an independent immuno-pathologic process, unknown. Methods was acquired from detailed post-mortem examinations conducted on 11 well characterised hospitalised patients fatal SARS-CoV-2 organotropism mapped at level...
The success of immune checkpoint therapy shows tumor-reactive T cells can eliminate cancer but are restrained by immunosuppression within the tumor micro-environment (TME). Cancer associated fibroblasts (CAFs) dominant stromal cell in TME and co-localize with non-small lung cancer. We demonstrate bidirectional nature CAF/T interactions; promote expression co-inhibitory ligands, MHC molecules CD73 on CAFs, increasing their production IL-6 eliciting IL-27. In turn CAFs upregulate receptors...
Abstract Fibroblast activation protein α (FAP) is a post-proline protease and solid-tumor target which Avacta’s pre|CISION® peptide moiety linker selectively uses as differentiated means to the tumor microenvironment (TME). The potential of technology highlighted by promising clinical data from AVA6000, enabled Doxorubicin drug conjugate. FAP expression tightly regulated in normal adult tissues, with low undetectable levels most healthy cells. However, it becomes highly upregulated TME where...
Cystic fibrosis (CF) is a multiorgan disease caused by mutations of the cystic transmembrane conductance regulator (CFTR). In addition to respiratory impairment due mucus accumulation, viruses and bacteria trigger acute pulmonary exacerbations, accelerating progression mortality rate. Treatment complexity increases with patients' age, simplifying therapeutic regimen represents one key priorities in CF. We have recently reported discovery multitarget compounds able "kill two birds stone"...
Telomerase negative cancer cell types use the Alternative Lengthening of Telomeres (ALT) pathway to elongate telomeres ends. Here, we show that silencing human DNA polymerase (Pol λ) in ALT cells represses activity and induces telomeric stress. In addition, replication stress absence Pol λ, strongly affects survival cells. vitro, λ can promote annealing even a single G-rich repeat its complementary strand it prime synthesis. The noncoding containing RNA TERRA protein A negatively regulate...