A5081995493- Bone health and treatments
- Radiopharmaceutical Chemistry and Applications
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Prostate Cancer Treatment and Research
- Extracellular vesicles in disease
University of Edinburgh
2020-2023
MRC Centre for Reproductive Health
2020-2023
Queen's Medical Centre
2023
Medical Research Council
2020
Metastatic castration-resistant prostate cancer (PC) is the final stage of PC that acquires resistance to androgen deprivation therapies (ADT). Despite progresses in understanding disease mechanisms, specific contribution metastatic microenvironment ADT remains largely unknown. The current study identified macrophage major microenvironmental component bone-metastatic patients. Using a novel vivo model, we demonstrated macrophages were critical for enzalutamide through induction...
Bone metastasis is the major cause of death in breast cancer. The lack effective treatment suggests that disease mechanisms are still largely unknown. As a key component tumor microenvironment, macrophages promote progression and metastasis. In this study, we found abundant human mouse cancer bone metastases. Macrophage ablation significantly inhibited growth. Lineage tracking experiments indicated these derive from Ly6C+CCR2+ inflammatory monocytes. Ablation chemokine receptor, CCR2,...