A5051357474- Inflammatory Bowel Disease
- Axon Guidance and Neuronal Signaling
- Chromatography in Natural Products
- Clostridium difficile and Clostridium perfringens research
- Blood Coagulation and Thrombosis Mechanisms
- Sphingolipid Metabolism and Signaling
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Adenosine and Purinergic Signaling
- Cystic Fibrosis Research Advances
- Hemophilia Treatment and Research
- Microscopic Colitis
- Inhalation and Respiratory Drug Delivery
- Neonatal Respiratory Health Research
- Macrophage Migration Inhibitory Factor
- Pharmaceutical studies and practices
- Pharmacological Effects of Natural Compounds
- Helicobacter pylori-related gastroenterology studies
- Genetic factors in colorectal cancer
- Digestive system and related health
- Immunotherapy and Immune Responses
- Chemokine receptors and signaling
- Flavonoids in Medical Research
- Gut microbiota and health
University of Parma
2019-2022
Université Toulouse III - Paul Sabatier
2020
Digestive Health Research Institute
2020
École Nationale Vétérinaire de Toulouse
2020
Inserm
2020
Université de Toulouse
2020
Besides their long-known critical role in embryonic growth and cancer development progression, erythropoietin-producing hepatocellular carcinoma type B (EphB) receptor tyrosine kinases ephrin-B ligands are involved the modulation of immune responses remodeling maintaining integrity intestinal epithelial layer. These processes critically pathogenesis inflammatory-based disorders gut, like inflammatory bowel diseases (IBDs). Accordingly, our aim was to investigate EphB/ephrin-B system...
Abstract Background and Aims Thrombin levels in the colon of Crohn’s disease patients have recently been found to be elevated 100-fold compared with healthy controls. Our aim was determine whether how dysregulated thrombin activity could contribute local tissue malfunctions associated disease. Methods studied tissues from Intracolonic administration wild-type or protease-activated receptor-deficient mice used assess effects mechanisms upregulation. Colitis induced rats by intracolonic...
Cystic fibrosis (CF) is a multiorgan disease caused by mutations of the cystic transmembrane conductance regulator (CFTR). In addition to respiratory impairment due mucus accumulation, viruses and bacteria trigger acute pulmonary exacerbations, accelerating progression mortality rate. Treatment complexity increases with patients' age, simplifying therapeutic regimen represents one key priorities in CF. We have recently reported discovery multitarget compounds able "kill two birds stone"...
Mesenteric ischemia/reperfusion (I/R), following the transient deprivation of blood flow to gut, triggers an acute flogistic process involving disruption endothelial and epithelial barriers integrity, activation immune cells, abundant release inflammatory mediators. Among them, lipid mediator sphingosine-1-phosphate (S1P) is involved in maintaining barrier integrity governing migration cells through interaction with S1P1–5 receptors. Therefore, present work aims investigate involvement S1P...
Eph receptors, comprising A and B classes, interact with cell-bound ephrins generating bidirectional signaling. Although mainly related to carcinogenesis organogenesis, the role of Eph/ephrin system in inflammation is growingly acknowledged. Recently, we showed that EphA/ephrin-A proteins can modulate acute inflammatory responses induced by mesenteric ischemia/reperfusion, while beneficial effects were granted EphB4, acting as EphB/ephrin-B antagonist, a murine model Crohn’s disease (CD)....
Alterations of gut microbiota have been implicated in a broad variety intestinal diseases. The mechanisms whereby this may occur remains elusive. Gut mucosal is naturally organized as polymicrobial biofilm, separated from the epithelium by sterile mucus layer. We recently discovered that releases active thrombin, which plays key role segregation biofilms host tissue. Furthermore, we detected an upregulation thrombin inflamed human patients and models colitis. Objectives Our study objective...
Background Current therapies for Inflammatory Bowel Disease (IBD) are unsatisfactory proper tissue healing. Serine proteases belong to locally produced host factors that can fuel inflammatory processes in from IBD patients, part through activation of Protease‐Activated Receptors (PAR). We have recently discovered intestinal epithelium was able produce active thrombin, suggesting mucosa itself could be an important source high thrombin IBD. Objectives first aimed determine whether mucosal...