Alcoholic liver disease has emerged as a leading indication for hepatic transplantation, although it is controversial use of resources. We aimed to examine all aspects transplantation associated with alcohol abuse.Retrospective cohort analysis 123 alcoholic patients median 7 years follow-up at one center.In addition alcohol, 43 (35%) had another possible factor contributing cirrhosis. Actuarial patient and graft survival rates were, respectively, 84% 81% (1 year); 72% 66% (5 years); 63% 59%...

Background: Carbohydrate deficient transferrin (CDT), a biochemical marker of chronic alcohol consumption, is used by researchers and clinicians alike in variety populations. Levels CDT may be affected certain types medical illnesses conditions. Thus the interpretation results need to carefully examined these Because synthesized, glycosylated, secreted liver, use values patients with liver disease has been an area focused interest. Methods: We evaluated 79 abstaining end‐stage disease. These...

Context-Little is known about patients' contribution to health outcomes after liver transplantation.Yet, in other transplant recipients, nonadherent behavior directly related the leading causes of morbidity and mortality recipients.Objective-To examine patient environmental factors relation all aspects adherence posttransplantation regimen first 6 months transplantation.Design-A descriptive analysis individual at transplantation.Participants, Setting-One hundred fifty-two adult recipients...

Calcineurin-inhibiting immunosuppressive medications are the mainstay of posttransplant immunosuppression. Although these highly beneficial drugs critical for survival, significant numbers transplant recipients experience side effects, some requiring a switch to different regimen. Neurotoxicity is one most debilitating effects because its impact on mental status and cognition. As our center uses tacrolimus as initial immunosuppressant all liver (LTX) recipients, we were interested in those...

Posttransplant lymphoproliferative disorder (PTLD) is a well-established complication of immunosuppression. The involvement the gastrointestinal (GI) tract occurs in 25% all cases PTLD. Fortunately, surgical intervention seldom required. We report our experience treatment complicated GI-PTLD after liver transplantation (LTx).A retrospective analysis 5677 adult patients who underwent LTx between 1983 and 2009 was conducted.Thirty-six presented with GI-PTLD. Sixteen complications associated...

Lung transplant candidates face numerous health-related stressors. Although previous work has described the range of coping strategies may use, whether those are related to quality life in physical functioning, emotional, and social domains rarely been examined.Adult lung (N = 128) participated semistructured interviews that included questions regarding global domain-specific a multidimensional assessment with problems. Demographic characteristics, health status, other psychosocial variables...

At our center from August 1989 to December 1992, 834 adults underwent orthotopic liver transplantation (OLT) using tacrolimus as the primary immunosuppressive agent. A total of 183 (22%) had alcohol-related disease. Patients with alcoholic cirrhosis a better though not statistically significant 5-year survival rate compared all other patients. We were interested in specific predictors survival, particularly for cirrhotics who gravely ill at point transplantation.For 78 patients disease...

Background: Methods to improve assessment, selection, and monitoring of patients with alcoholic cirrhosis who pursue liver transplantation are sought continuously. We chose investigate the use High‐Risk Alcohol Relapse (HRAR) scale in our transplant population hope that it would ability identify follow at highest risk for alcohol relapse. Methods: Detailed histories 207 evaluated were collected graded severity by using HRAR. The HRAR provides information on duration (a measure chronicity),...

Transferrin, an iron transport protein found in serum and cerebrospinal fluid, is known to be microheterogeneous with respect its carbohydrate sialic acid content. The forms of transferrin deficient and/or carbohydrate, termed carbohydrate-deficient (CDT), have been clinical interest for almost two decades as a result the initial finding that elevated CDT concentrations are associated chronic, excessive alcohol abuse. We demonstrate utility capillary electrophoresis examining sialoform...

ABSTRACT Objectives Early alcohol use identification can prevent morbidly/mortality for alcohol-associated liver disease (ALD). Innovative wearable biosensors (biosensors) that identify through perspiration are an emerging technology with potential application Patients ALD. Our primary aim was to determine biosensor acceptability and feasibility We describe participant acceptance challenges using in a pilot study of Design Participants had recent diagnosis or hospitalization decompensated...

CONTEXT-Patient characteristics are important in the liver transplant (LTX) population because of proven associations between individual and environmental factors, treatment adherence, health outcomes general medical other (txp) populations. OBJECTIVE-The objective this report is to determine generalizability sample LTX populations establish reliability measures used assess resources.DESIGN-This a cross sectional analysis baseline data longitudinal study adherence outcomes.PARTICIPANTS,...

LaPUMA, J.; STOCKING, C. B. M. D.; SILVERSTEIN, ; DIMARTINI, A.; SIEGLER, Author Information

A. Liver transplantation (LT) patients with alcoholic liver disease (ALD) often have the comorbid psychiatric disorder of alcohol dependence (AD). 1. Not all AD will develop ALD. 2. Most, but not patients, ALD be AD. 3. Approximately 75-80% LT B. Diagnostic criteria use disorders. Alcohol abuse. a. Clinically important impairment or distress repeatedly in one more following items a 12-month period. i. Failure to fulfill major obligations (e.g., absences/suspension from work, neglecting...

Abstract Introduction We aimed to determine acceptability and feasibility of innovative wearable alcohol biosensor monitors (ABM) for patients with alcohol‐related liver disease (ALD) their clinicians. Methods Patients clinicians at a tertiary care centre participated in qualitative interviews on usability, acceptability, feasibility, efficiency/effectiveness, impact device behaviour/clinical practice preferences/barriers. Interviews were audiotaped, transcribed coded using constant...

Alcohol-related liver disease has become one of the most common indications for transplantation. Over past decade, our clinical experience with patients transplanted alcohol-related coupled multidecade studies from general alcoholic population have given direction to research questions this unique patient population. Although concerns over posttransplant alcohol relapse are foremost, few return pathologic drinking that results in morbidity or mortality. Beginning attempts at modeling...

Background: Carbohydrate deficient transferrin (CDT), a biochemical marker of chronic alcohol consumption, is used by researchers and clinicians alike in variety populations. Levels CDT may be affected certain types medical illnesses conditions. Thus the interpretation results need to carefully examined these Because synthesized, glycosylated, secreted liver, use values patients with liver disease has been an area focused interest. Methods: We evaluated 79 abstaining end-stage disease. These...