A5101742379- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Organ Transplantation Techniques and Outcomes
- Brain Metastases and Treatment
- Pelvic floor disorders treatments
- Prostate Cancer Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- CAR-T cell therapy research
- MRI in cancer diagnosis
- Liver Disease and Transplantation
- Renal Transplantation Outcomes and Treatments
- Lung Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Multiple Sclerosis Research Studies
- Lymphoma Diagnosis and Treatment
- Epilepsy research and treatment
- Pharmaceutical Practices and Patient Outcomes
- Chronic Lymphocytic Leukemia Research
- Brain Tumor Detection and Classification
- Cancer Research and Treatments
- Transplantation: Methods and Outcomes
- Urinary Bladder and Prostate Research
- Aortic Disease and Treatment Approaches
Riverside Community Hospital
2024
University of North Carolina at Chapel Hill
2019-2024
Fred Hutch Cancer Center
2023
University of Michigan–Ann Arbor
1989-2023
Michigan United
2023
Stanford University
2022-2023
National Hemophilia Foundation
2021-2023
University of Hawaii at Hilo
2020-2023
NYU Langone Health
2023
Memorial Sloan Kettering Cancer Center
2023
Abstract Objective To study 5 type I interferon (IFN)–inducible genes (LY6E, OAS1, OASL, MX1, and ISG15) in patients with systemic lupus erythematosus (SLE) to correlate expression levels disease activity and/or clinical manifestations. Methods Peripheral blood cells were obtained from 48 SLE patients, normal controls, 22 rheumatic total RNA was extracted reverse transcribed into complementary DNA. Gene measured by real‐time polymerase chain reaction, standardized a housekeeping gene, summed...
Abstract Can engaging college students in client‐centered projects science, technology, engineering, and mathematics (STEM) coursework increase interest STEM professions? The current study explored the effectiveness of project‐based learning (PjBL) courses on student attitudes, major choice, career aspirations STEM. Framed expectancy‐value social cognitive choice models, we examined effect at least one authentic, course during first four semesters attitudes a quasi‐experimental with sample (...
Disease-modifying therapies (DMTs) for multiple sclerosis (MS) target immunity and have the potential to increase risk of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection alter its clinical course. We assessed these risks in patients with MS (PwMS). The objective this study was describe overall coronavirus disease 2019 (COVID-19) infection, course, population-level predictors COVID-19 PwMS, provide a context using cohort systemic lupus erythematosus (SLE). In addition,...
Differentiating pseudoprogression from true tumor progression has become a significant challenge in follow-up of diffuse infiltrating gliomas, particularly high grade, which leads to potential treatment delay for patients with early glioma recurrence. In this study, we proposed use multiparametric MRI data as sequence input the convolutional neural network recurrent based deep learning structure discriminate between and progression. 43 biopsy-proven patient identified whose disease...
Background The National Hemophilia Foundation (NHF) conducted extensive all-stakeholder inherited bleeding disorder (BD) community consultations to inform a blueprint for future research. Sustaining and expanding the specialized comprehensive Treatment Center care model, better serve all people with BDs (PWIBD), increasing equitable access optimal health emerged as top priorities.Research Design Methods NHF, American Thrombosis Hemostasis Network (ATHN), convened multidisciplinary expert...
ABSTRACT The Candida albicans cell wall participates in both growth and morphological transitions between yeast hyphae. Our studies here focus on Dfg5p Dcw1p, two similar proteins with features of glycosylphosphatidylinositol-linked surface proteins. Mutants lacking are defective alkaline pH-induced hypha formation; mutants Dcw1p have no detected formation defect. Both homozygote-triplication tests conditional expression strategies indicate that dfg5 dcw1 mutations synthetically lethal....
Duchenne muscular dystrophy, the most common form of childhood is caused by X-linked inherited mutations in dystrophin gene. Dystrophin deficiencies result loss dystrophin–glycoprotein complex at plasma membrane, which leads to structural instability and muscle degeneration. Previously, we induced muscle-specific overexpression Akt, a regulator cellular metabolism survival, mdx mice pre-necrotic (<3.5 weeks) ages demonstrated upregulation utrophin–glycoprotein protection against...
A Prospective Clinical Study to Evaluate the Safety and Performance of Wireless Localization Nonpalpable Breast Lesions Using Radiofrequency Identification TechnologyChristine Dauphine1, Joshua J. Reicher2, Murray A. Reicher3, Christina Gondusky1, Iraj Khalkhali4 Michelle Kim1Audio Available | Share
Background: Behavioral pathologies that characterize alcohol use disorder (AUD) are driven by the powerful reinforcing, or rewarding, properties of drug. We have shown glutamate AMPA receptor (AMPAR) activity is both necessary and sufficient for (ethanol) reinforcement. Transmembrane AMPAR regulatory protein (TARP) γ-8 an essential auxiliary regulates expression activity; however, role TARP ɣ-8 in AUD other forms addiction remains largely unexplored. Objectives: This study investigated...
Abstract Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher undertake targeted screening. However, current PRS using European ancestry data sub-optimal performance in non-European populations, limiting their utility among these populations. Towards addressing this deficiency, we expand development for CRC incorporating Asian (21,731 cases; 47,444 controls) into training datasets (78,473 107,143 controls). The...
Chronic seizures in women can have adverse effects on reproductive function, such as polycystic ovarian syndrome, but it has been difficult to dissociate the of epilepsy from role antiepileptic drugs. To distinguish chronic medication, we used laboratory rat, because an epileptic condition be induced without concomitant anticonvulsant drug treatment.Adult female rats were administered chemoconvulsant pilocarpine initiate status epilepticus, which was decreased severity by diazepam. These...
Duchenne muscular dystrophy is caused by dystrophin mutations that lead to structural instability of the sarcolemma membrane, myofiber degeneration/regeneration and progressive muscle wasting. Here we show myogenic Akt signaling in mouse models promotes increased expression utrophin, which replaces function thereby preventing damage In contrast previous suggestions was a secondary consequence pathology, our findings demonstrate pivotal role for this pathway such modulation can significantly...
No AccessJournal of UrologyAdult Urology: Voiding Dysfunction1 Oct 2005HIGH INCIDENCE OF VAGINAL MESH EXTRUSION USING THE INTRAVAGINAL SLINGPLASTY SLING ANDREW L. SIEGEL, MICHELLE KIM, MARTIN GOLDSTEIN, STUART LEVEY, and PEDRAM ILBEIGI SIEGELANDREW SIEGEL , KIMMICHELLE KIM GOLDSTEINMARTIN GOLDSTEIN LEVEYSTUART LEVEY ILBEIGIPEDRAM View All Author Informationhttps://doi.org/10.1097/01.ju.0000173927.74235.e9AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack...
Background: Changes in resident outcomes may be driven by many factors, including changes nursing home care processes. Understanding what processes, if any, lead to successful improvements could create a stronger case for the continued use of these outcome measures report cards. Objective: To test extent which are explained setting where, our knowledge, this link has not been previously studied. Research Design/Measures: We describe facility-level processes and before after were publicly...
Abstract Background For communities of people living with hemophilia and other genetic conditions, gene therapy could represent a paradigm shift in treatment strategies. As investigational therapeutic modalities such as become more widely used discussed, there is critical need for all stakeholders to communicate using lexicon that intelligible, accurate, consistent, representative novel treatments. In doing so, expectations can be carefully managed potential risks, benefits, limitations...