A5022074459- Hemophilia Treatment and Research
- Platelet Disorders and Treatments
- Uterine Myomas and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Blood groups and transfusion
- Iron Metabolism and Disorders
- Endometriosis Research and Treatment
- Hemoglobinopathies and Related Disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Chronic Myeloid Leukemia Treatments
- Gynecological conditions and treatments
- Cancer-related gene regulation
- Genital Health and Disease
- Blood donation and transfusion practices
- Antiplatelet Therapy and Cardiovascular Diseases
- Venous Thromboembolism Diagnosis and Management
- Diabetes Treatment and Management
- Erythropoietin and Anemia Treatment
- Adolescent and Pediatric Healthcare
- Public Health Policies and Education
- Sexual function and dysfunction studies
- Urologic and reproductive health conditions
- Urological Disorders and Treatments
- Urticaria and Related Conditions
- Maternal and fetal healthcare
National Center on Birth Defects and Developmental Disabilities
2012-2023
Centers for Disease Control and Prevention
2010-2023
Biotherapy of Genetic Diseases, Inflammatory Disorders and Cancers
2011
Institute of Cytology
2011
The optimal management of menorrhagia among women with abnormal laboratory haemostasis is uncertain. In a crossover study, 116 [pictorial blood assessment chart (PBAC) score >100], negative gynaecological evaluation and were randomly assigned to either intranasal desmopressin (IN-DDAVP) or tranexamic acid (TA) therapy for two menstrual cycles. subjects then crossed over the second study drug additional Menstrual loss (MBL) was measured by PBAC scores at baseline after each cycle. Quality...
Background The National Hemophilia Foundation (NHF) conducted extensive all-stakeholder inherited bleeding disorder (BD) community consultations to inform a blueprint for future research. Sustaining and expanding the specialized comprehensive Treatment Center care model, better serve all people with BDs (PWIBD), increasing equitable access optimal health emerged as top priorities.Research Design Methods NHF, American Thrombosis Hemostasis Network (ATHN), convened multidisciplinary expert...
Summary. Inherited bleeding disorders are especially problematic for affected girls and women due to the monthly occurrence of menstrual periods effects on reproductive health. Although heavy (HMB) is most common manifestation, females with inherited (FBD) experience other symptoms throughout lifespan that can lead increased morbidity impairment daily activities. The purpose this article describe utility a female‐focused surveillance effort [female Universal Data Collection (UDC) project] in...
Abstract Introduction Females may have haemophilia with the same factor VIII (FVIII) or IX (FIX) levels as affected males. Characterization of females would be useful for health care planning to meet their unique needs. Federally‐funded treatment centres (HTCs) in United States contribute data on all individuals bleeding disorders receiving Population Profile (HTC PP) component Community Counts Public Health Surveillance Bleeding Disorders project. Aims To estimate number at HTCs and compare...
Summary. While an estimated 13% of women with unexplained menorrhagia have von Willebrand disease (VWD), the frequency other potential bleeding disorders has been uncertain. This study describes relatively wide range laboratory characteristics and presents issues affecting diagnosis in this population. Women pictorial blood assessment chart (PBAC) score >100 were identified at six U.S. sites asked to remain drug free for 10 days prior testing. Blood was collected on one first four...
Introduction Health‐related quality of life ( HRQ oL) is reduced among persons with haemophilia. Little known about how oL varies complications haemophilia such as inhibitors and joint disease. Estimates preference‐based measures are needed to model the cost‐effectiveness prevention strategies. Aim We examined characteristics a national sample severe A for associations two oL. Methods analysed utility weights converted from EuroQol 5 Dimensions EQ ‐5D) Short Form 6 SF ‐6D) scores 1859 males...
In the network of U.S. comprehensive haemophilia treatment centres (HTCs), von Willebrand disease (VWD) is most common bleeding disorder other than haemophilia. Estimates size and characteristics VWD population receiving are useful for healthcare planning.Estimate prevalence incidence among males females care at HTCs (HTC-treated incidence).During period 2012-2019, de-identified surveillance data were collected on all patients who visited an HTC including year birth, sex, race, Hispanic...
Introduction Due to lack of patient/health care provider awareness causing delayed diagnosis, the bleeding phenotype and interventions in adolescents with heavy menstrual ( HMB ) disorders BD may be different when compared adults. Aim The aim this study was compare/characterize postmenarchal < 18 years premenopausal adults ≥ . Methods Patient demographics, , interventions/therapy details for were between both age groups enrolled Centers Disease Control Prevention CDC Female Universal Data...
Although obstetrician/gynecologists (OB/GYNs) play an important role in sickle cell disease (SCD) screening and patient care, there is little information on knowledge of SCD or trait (SCT) related practices this provider group. Our objective was to assess prenatal management among OB/GYNs. Twelve hundred Fellows Junior the American College Obstetricians Gynecologists (the College)a were invited complete a mailed survey, which half (n = 600) belonged Collaborative Ambulatory Research...
Abstract There are limited observational studies among children diagnosed with von Willebrand Disease (VWD). We analyzed differences in bleeding characteristics by sex and type of VWD using the largest reported surveillance database (n = 2712), ages 2 to 12 years old. found that mean first bleed diagnosis were lowest 3 VWD. It was even lower boys than girls all types, statistically significant difference 1 or Children also higher proportions ever having a compared other reporting A similar...
Nonmalignant blood disorders currently affect millions of Americans, and their prevalence is expected to grow over the next several decades. This owing improvements in treatment leading increased life expectancy people with hereditary conditions, like sickle cell disease hemophilia, but also rising occurrence risk factors for venous thromboembolism. The lack adequate surveillance systems monitor these conditions associated health indicators a significant barrier successfully assess, inform,...
A new CDC analysis of data from eight African countries shows the importance screening for bleeding disorders before voluntary medical male circumcision (VMMC), promptly detecting and managing complications, maintaining surveillance systems to monitor adverse events.
Hemophilia is an X-linked genetic disorder that primarily affects males and results in deficiencies blood-clotting proteins. A a deficiency factor VIII, hemophilia B IX. Approximately one 5,000 are born with hemophilia, about four times as common B. Both disorders characterized by spontaneous internal bleeding excessive after injuries or surgery. can lead to repeated into the joints associated chronic joint disease, neurologic damage, damage other organ systems, death. Although no precise...
Menorrhagia, or excessive menstrual bleeding, is a common clinical problem affecting reproductive-age women; however, the cause undetermined in 50% of cases. Von Willebrand disease (VWD) other bleeding disorders may be underlying source heavy bleeding. Women with menorrhagia and/or VWD are at increased risk for several conditions including anemia, during pregnancy, post-partum hemorrhage, and reduced quality life (OOL). Proper diagnosis management can decrease complications unnecessary...
Abstract Data on infants and toddlers (ITs) with von Willebrand disease (VWD) are lacking. We used data collected in the US Hemophilia Treatment Center Network (USHTCN) to describe birth characteristics, bleeding episodes, complications experienced by 105 patients VWD who were &lt;2 years of age. In 68% patients, reason for diagnostic testing was a family history disorder. The mean age at diagnosis 7 months, little variation sex. Patients type 2 diagnosed earlier than those types 1 or 3...
Bleeding and clotting in women is an issue that directly affects the life of every woman, child, family worldwide. This article summarizes recent activities undertaken by Division Blood Disorders (DBD) at Centers for Disease Control Prevention (CDC) to identify risk factors through evidence-based research surveillance prevent complications blood disorders women. Specific focus given our efforts improve early identification diagnosis among women, understanding maternal infant outcomes,...