A5101483042- Alzheimer's disease research and treatments
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Salmonella and Campylobacter epidemiology
- Viral gastroenteritis research and epidemiology
- COVID-19 Clinical Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Parkinson's Disease Mechanisms and Treatments
- Biosensors and Analytical Detection
- Vibrio bacteria research studies
- Biotin and Related Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Bacteriophages and microbial interactions
- Curcumin's Biomedical Applications
- Viral Infections and Immunology Research
- Aldose Reductase and Taurine
- Streptococcal Infections and Treatments
- Protein Degradation and Inhibitors
- Diphtheria, Corynebacterium, and Tetanus
- Nanoplatforms for cancer theranostics
- Cholinesterase and Neurodegenerative Diseases
- Advanced Biosensing Techniques and Applications
- Hepatitis Viruses Studies and Epidemiology
- Neurological disorders and treatments
- Cellular transport and secretion
Shenzhen Center for Disease Control and Prevention
2016-2025
National Institute for Communicable Disease Control and Prevention
2024-2025
Harbin Medical University
2020-2025
New York University
2021-2024
Chinese Center For Disease Control and Prevention
2024
Center for Disease Control
2024
NYU Langone Health
2024
Guangdong Medical College
2022
Managing recovered COVID-19 patients with recurrent-positive SARS-CoV-2 RNA test results is challenging. We performed a population-based observational study to characterize the viral level and serum antibody responses in evaluate their transmission risk. Of 479 patients, 93 (19%) were identified, characterized by younger age, median discharge-to-recurrent-positive length of 8 days. After readmission, exhibited mild (28%) or absent (72%) symptoms, no disease progression. The ranged from 1.8...
Intracellular deposition of α-synuclein and tau are hallmarks synucleinopathies tauopathies, respectively. Recently, several dye-based imaging probes with selectivity for aggregates have been developed, but suitable biomarkers still unavailable. Detection both these early in the disease process may allow prophylactic therapies before functional impairments manifested, highlighting importance developing specific lesions. In contrast to β sheet dyes, single-domain antibodies, found camelids a...
Acute infectious gastroenteritis is one of the most common diseases among all ages, particularly in developing countries. The pathogen spectrum may differ different regions and seasons. To investigate etiology acute diarrhea Shenzhen, a prospective study was conducted from August 2014 to September 2015. Stools 412 patients with (286 whom were adults) including general epidemiological information collected. 19 pathogens detected by conventional culture method or multiplex PCR assay, which...
Stem cells utilized for ischemic stroke treatment often display unstable homing capabilities and diminished activity in vivo, limiting their neuroprotective efficacy. Furthermore, the optimal delivery route stem remains undetermined. While cytokines secreted by show promise modulating post-stroke inflammation, direct application of these supernatants underlying mechanisms are still unclear. Secretory (hMSC-L) cell lysate products (hMSC-M) from primary human umbilical cord mesenchymal...
Highlights•Multiple imports and exports of S. Typhi Paratyphi A strains exist in Shenzhen.•. Genomic clustering reveals silent outbreaks missed by epidemiological surveillance.•Antimicrobial resistance enteric fever pathogens is not severe Shenzhen.AbstractObjectivesOutbreak the spread antimicrobial-resistant Salmonella pose significant public health challenges low- middle-income countries. Understanding transmission dynamics these essential for developing effective control...
Abstract Background SARS-CoV-2 is a newly emerged coronavirus, causing the coronavirus disease 2019 (COVID-19) outbreak in December, 2019. As drugs and vaccines of COVID-19 remain development, accurate virus detection plays crucial role current public health crisis. Quantitative real-time reverse transcriptase-polymerase chain reaction (RT-qPCR) kits have been reliably used for RNA since beginning outbreak, whereas isothermal nucleic acid amplification-based point-of-care automated also...
Cerebral ischemia-reperfusion injury induces a secondary immune inflammatory reaction that exacerbates brain and clinical prognosis. Dendritic cells (DCs) microglia are both important regulators of neuroinflammation. Studies have confirmed large number express the DC surface marker CD11c in ischemic area, some these also microglial markers. However, specific mechanism transformation between DCs their roles process cerebral still not clear. In this study, we established mouse model flow...
<title>Abstract</title> Tauopathies are a group of neurodegenerative diseases characterized by the presence tau inclusions. We have developed over fifty anti-tau single domain antibodies (sdAbs) derived from phage display libraries llama immunized with recombinant and pathological immunogens. examined therapeutic potential four these sdAbs in <italic>Drosophila</italic> tauopathy model following their transgenic expression either all neurons or neuronal subtypes. Three showed various assays,...
To understand the prevalence, genetic characteristics and drug resistance features of Salmonella Kentucky ST314 in Shenzhen.
Background: Enteric fever remains a serious public health problem. S. Typhi and Paratyphi A are the two predominant causes of enteric fever. The spread outbreaks caused by antimicrobial resistant pathogens pose major threat to health. Understanding transmission dynamics these is crucial for design implementation effective control strategies.Methods: In this study, we sequenced 135 isolates 271 in Shenzhen from 2001 2017. Phylogenomic analysis Bayesian were employed investigate combining...
Abstract Tauopathies are a group of neurodegenerative diseases characterized by the presence tau inclusions. We have developed over fifty anti-tau single-domain antibodies (sdAbs) derived from phage display libraries llama immunized with recombinant and pathological immunogens. examined therapeutic potential four these sdAbs in Drosophila tauopathy model following their transgenic expression either all neurons or neuronal subtypes. Three showed various assays, effectively clearing...
Rapid and accurate identification of Salmonella enterica serotypes Typhi Paratyphi (A, B C), the causal agents enteric fever, is critical for timely treatment, case management evaluation health policies in low middle-income countries where disease still remains a serious public problem. The present study describes development multiplex assay (EFMAtyping) simultaneous pathogens causing typhoid paratyphoid fever single reaction by MeltArray approach, which could be finished within 2.5 h. Seven...
Abstract Background Synucleinopathies lack cures. Antibody therapies targeting α‐synuclein aim to inhibit aggregation and enhance degradation, but have limited brain entry because of size (150kDa). Smaller single‐domain antibodies (sdAbs, 15kDa) substantially improved uptake. Previously, we developed sdAb‐based probes (2D10 2D8) enabling specific imaging in mice post i.v. injection, correlating with lesion burden, indicating therapeutic diagnostic potential (Jiang Y et al Sci Adv 2023)....
Summary Background Managing discharged COVID-19 (DC) patients with recurrent positive (RP) SARS-CoV-2 RNA test results is challenging. We aimed to comprehensively characterize the viral level and serum antibody responses in RP-DC evaluate their transmission risk. Methods A population-based observational cohort study was performed on 479 DC from February 1 May 5, 2020 Shenzhen, China. conducted RT-qPCR, assays, neutralisation virus isolation, whole genome sequencing (WGS), epidemiological...
Clostridium botulinum produces neurotoxins (BoNTs), which cause people who ingest them to become seriously ill and sometimes die. In recent years, sporadic food poisoning cases associated with C. have occurred across the world. 2016, two men were admitted our hospital in Shenzhen, China, foodborne botulism. this study, we report on these typical botulinum-related incidents steps taken identify characterize causative pathogen. We characterized bacterial pathogen isolated from first patient...
Abstract Background Synucleinopathies and tauopathies are characterized by progressive deposition of α‐synuclein (α‐syn) tau proteins, respectively. These diseases have been linked to proteins mutations or excess α‐syn gene, indicating prominent roles these in their etiology pathogenesis. Consequently, being able non‐invasively image aggregates would allow early accurate diagnosis facilitate clinical trials on drugs targeting lesions eventually for prophylactic therapies. Recently, several...
Abstract SARS-CoV-2 is a newly emerged coronavirus that was isolated from human infections in recent months. Since drugs and vaccines of Covid-19 are still being developed, accurate pathogen detection plays crucial role the current public health crisis. Quantitative real-time reverse transcriptase-polymerase chain reaction (RT-PCR) assay has been reliably used for confirmation since beginning outbreak, whereas isothermal nucleic acid amplification based point care automated assays also...
Abstract Background: Recently many literature were reported on the re-detectable positive phenomenon of COVID-19 patients during recovery, but there few studies lymphocyte subsets and T-lymphocyte activation indicators between RP (re-detectable positive) NRP (non-re-detectable patients. The aim this study was to analyze immunological characteristics among convalescent from post-discharge Methods: Anticoagulated whole blood samples collected 11HCs (healthy controls) 66 patients, then...
Abstract Background Numerous studies have shown that the extent of pathological tau protein in brain correlates strongly with severity Alzheimer’s dementia at time death, and similar association functional phenotypes been seen other tauopathies. In recent years, several dye‐based imaging probes selectivity for aggregates developed. However, all are β‐sheet binders varying affinity different amyloids, thereby lack specificity lesions. contrast, single domain antibodies (sdAbs) specific their...
Abstract Background: SARS-CoV-2 is a newly emerged coronavirus, causing the coronavirus disease 2019 (COVID-19) outbreak in December, 2019. As drugs and vaccines of COVID-19 remain development, accurate virus detection plays crucial role current public health crisis. Quantitative real-time reverse transcriptase-polymerase chain reaction (RT-qPCR) kits have been reliably used for RNA since beginning outbreak, whereas isothermal nucleic acid amplification-based point-of-care automated also...