A5025497942- Anesthesia and Sedative Agents
- Anesthesia and Neurotoxicity Research
- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Pain Management
- Membrane Separation Technologies
- Airway Management and Intubation Techniques
- Aortic Disease and Treatment Approaches
- Adsorption and biosorption for pollutant removal
- Nanopore and Nanochannel Transport Studies
- Nausea and vomiting management
- Membrane Separation and Gas Transport
- Spine and Intervertebral Disc Pathology
- Music Therapy and Health
- Hemodynamic Monitoring and Therapy
- Carbohydrate Chemistry and Synthesis
- Meta-analysis and systematic reviews
- MXene and MAX Phase Materials
- Total Knee Arthroplasty Outcomes
- Advanced Photocatalysis Techniques
- Bee Products Chemical Analysis
- Peptidase Inhibition and Analysis
- Glycosylation and Glycoproteins Research
- Aortic aneurysm repair treatments
- Mineral Processing and Grinding
North Sichuan Medical University
2014-2025
Nanchong Central Hospital
2014-2025
Capital Medical University
2025
Chengdu Medical College
2023-2025
Southern Medical University
2024
Guangxi University
2022-2024
Henan Institute of Geological Survey
2023-2024
Second Military Medical University
2022-2024
Peking University International Hospital
2023
Affiliated Hospital of North Sichuan Medical College
2023
Propofol is the most widely used intravenous general anesthetic; however, neuronal circuits that mediate its anesthetic effects are still poorly understood. Glutamatergic neurons in lateral hypothalamus have been reported to be involved maintenance of arousal and consciousness. Using Vglut2-Cre transgenic mice, we recorded this group cells specifically found propofol can directly inhibit glutamatergic neurons, enhance inhibitory synaptic inputs on these cells, thereby reducing excitability....
Background: Acute kidney injury (AKI) is a common complication of cardiac surgery, which could lead to increased morbidity and mortality. type A aortic dissection (AAAD) life-threatening disease can be closely related post-operative AKI. However, data on the incidence AKI defined by newest Kidney Disease: Improving Global Outcomes (KDIGO) criteria in-hospital mortality homogeneous population who underwent AAAD are limited. We aimed investigate KDIGO risk factors associated with outcomes...
In spite of effective antiosteoporosis potency, teriparatide, a bone-building agent approved by the FDA (Food and Drug Administration), was proven to exhibit various side effects. our previous work, we developed universal strategy for synthesizing arginine N-glycosylated peptides termed silver-promoted solid-phase glycosylation (SSG) strategy. However, it is unknown whether SSG can be applied in peptide drug design. Herein, first reported optimization teriparatide via Using Arg20 and/or...
Melittin is a natural antimicrobial peptide isolated from bee venom, and the non-specific cytotoxicity hemolytic activity severely limit its clinical application. Glycosylation of proteins very common in physiological biochemical processes can modulate interaction with their target. In this study, eight glycosyl groups were used to modify arginine melittin at sites 22 and/or 24, single double N-glycosylated peptides designed synthesized. Among acquired 24 glycopeptides, MLT-1c, MLT-3c,...
To determine the median effective dose (ED50) and 95% (ED95) of ciprofol combined with sufentanil for inhibiting tracheal intubation response in female patients to evaluate hemodynamic stability adverse events associated this drug combination. This was a prospective dose-finding study using an up-and-down sequential allocation method. A total 30 undergoing general anesthesia surgeries between November 2024 December were enrolled. Patients administered induction, initial 0.4 mg/kg subsequent...
Abstract Objective: Remimazolam is a novel benzodiazepine sedative that provides effective sedation, stable haemodynamics, and minimal adverse effects during intravenous general anaesthesia. The aim of this study was to determine the 50% dose (ED50) remimazolam combined with different doses esketamine for painless gastroscopy evaluate efficacy safety combination. Methods: This randomised, double-blind, up-and-down sequential allocation study. Patients undergoing who met all inclusion...
Spiro[indoline-3,4'-piperidine] is a significant structural scaffold in numerous polycyclic indole alkaloids with variety of bioactivities. In this study, synthetic strategy was developed to access spiro[indoline-3,4'-pyridin]-2-yl carbamate via an AgOTf/PPh3-catalyzed tandem cyclization tryptamine-ynesulfonamides. The unique feature the efficient intermolecular capturing situ generated spiroindoleninium intermediates carbamates, leading diastereoselective syntheses derivatives. A broad...
The influence of different electric fields on the electronic structure and optical properties β-Ga2O3 was studied by GGA+U method. results show that appropriate field intensity can regulate band gap more effectively to improve photoelectric characteristics. value intrinsic is 4.865 eV, decreases from 4.732 2.757 eV with increase 0.05 0.20 Å-1. length O-Ga bond along increases fastest intensity, distance between O Ga reaches 2.52 Å when A new peak appears in real imaginary parts dielectric...
Lots of research on thermoelectric materials (TEs) has focused improving their (TE) properties to achieve efficient energy conversion. However, the mechanical are also object concern in practical applications. Nowadays, field electronic devices is obviously developing direction flexible electronics, so TEs should consider plasticity. Since 2018, it been discovered that inorganic semiconductor have ability plastic deformation, giving new possibilities for development with This paper focuses...