A5082024795- Microtubule and mitosis dynamics
- Photoreceptor and optogenetics research
- Protein Structure and Dynamics
- Spectroscopy and Quantum Chemical Studies
- Biofield Effects and Biophysics
- Computational Drug Discovery Methods
- Cancer therapeutics and mechanisms
- Theoretical and Computational Physics
- Advanced Thermodynamics and Statistical Mechanics
- Lipid Membrane Structure and Behavior
- Synthesis and biological activity
- Neural dynamics and brain function
- Photosynthetic Processes and Mechanisms
- Nonlinear Photonic Systems
- Nonlinear Dynamics and Pattern Formation
- Quantum Mechanics and Applications
- Bioinformatics and Genomic Networks
- Plant and Biological Electrophysiology Studies
- Gene Regulatory Network Analysis
- Cellular Mechanics and Interactions
- Advanced Chemical Physics Studies
- DNA Repair Mechanisms
- 14-3-3 protein interactions
- Neuroscience and Neural Engineering
- Cancer Treatment and Pharmacology
University of Alberta
2016-2025
Polytechnic University of Turin
2017-2025
Silesian University of Technology
2023-2025
Hospital Sírio-Libanês
2024
March of Dimes
2023
Czech Technical University in Prague
2021
Universitat de València
2021
University College London
2021
King's College London
2018-2021
Imperial College London
2021
Albumin is an appealing carrier in nanomedicine because of its unique features. First, it the most abundant protein plasma, endowing high biocompatibility, biodegradability, nonimmunogenicity, and safety for clinical application. Second, albumin chemical structure conformation allows interaction with many different drugs, potentially protecting them from elimination metabolism vivo, thus improving their pharmacokinetic properties. Finally, can interact receptors overexpressed diseased...
The novel coronavirus whose outbreak took place in December 2019 continues to spread at a rapid rate worldwide. In the absence of an effective vaccine, inhibitor repurposing or de novo drug design may offer longer-term strategy combat this and future infections due similar viruses. Here, we report on detailed classical mixed-solvent molecular dynamics simulations main protease (Mpro) enriched by evolutionary stability analysis protein. results were compared with those for highly severe acute...
The Penrose-Hameroff orchestrated objective reduction (orch. OR) model assigns a cognitive role to quantum computations in microtubules within the neurons of brain. Despite an apparently ``warm, wet, and noisy'' intracellular milieu, proposal suggests that avoid environmental decoherence long enough reach threshold for ``self-collapse'' (objective reduction) by gravity mechanism put forth Penrose. has been criticized as regards issue decoherence, recent report Tegmark finds can maintain...
We present the three-dimensional molecular theory of solvation (also known as 3D-RISM) coupled with dynamics (MD) simulation by contracting solvent degrees freedom, accelerated extrapolating solvent-induced forces and applying them in large multiple time steps (up to 20 fs) enable biomolecules. The method has been implemented Amber modeling package is illustrated here on alanine-dipeptide protein-G.
A model is presented that intended to provide a realistic physical picture of the energy-transfer mechanism in cell microtubules. classical ${\mathrm{\ensuremath{\varphi}}}^{4}$ presence constant electric field used as conceptual basis. It demonstrated kinklike excitations arise result guanosine 5'-triphosphate (GTP) hydrolysis and an intrinsic electrical force may cause them propagate along microtubule. discussion given on possible effects these dynamics
Alzheimer's disease (AD) is the most common form of dementia in elderly. Hallmark AD neuropathology includes extracellular amyloid plaques composed largely amyloid-β protein (Aβ), intracellular neurofibrillary tangles (NFTs) hyper-phosphorylated microtubule-associated tau (MAP-tau), and microtubule destabilization. Early-onset autosomal dominant genes are associated with excessive Aβ accumulation, however cognitive impairment best correlates NFTs disrupted microtubules. The mechanisms...
Memory is attributed to strengthened synaptic connections among particular brain neurons, yet membrane components are transient, whereas memories can endure. This suggests information encoded and 'hard-wired' elsewhere, e.g. at molecular levels within the post-synaptic neuron. In long-term potentiation (LTP), a cellular model for memory, calcium ion (Ca2+) flux activates hexagonal Ca2+-calmodulin dependent kinase II (CaMKII), dodacameric holoenzyme containing 2 sets of 6 domains. Each domain...
Breast cancer is one of the most prevalent types today in women. The main avenue diagnosis through manual examination histopathology tissue slides. Such a process often subjective and error-ridden, suffering from both inter- intraobserver variability. Our objective to develop an automatic algorithm for analysing slides free human subjectivity. Here, we calculate fractal dimension images numerous breast slides, at magnifications 40×, 100×, 200× 400×. Using machine learning, specifically,...
The 5-y survival for cancer patients after diagnosis and treatment is strongly dependent on tumor type. Prostate have a >99% chance of past 5 y diagnosis, pancreatic <6% y. Because each type has its own molecular signaling network, we asked if there are “signatures” embedded in these networks that inform us as to the survival. In other words, statistical metrics network correlate with survival? Furthermore, are, can such signatures provide clues selecting new therapeutic targets? From...
Abstract Given that many fundamental questions in neuroscience are still open, it seems pertinent to explore whether the brain might use other physical modalities than ones have been discovered so far. In particular is well established neurons can emit photons, which prompts question these biophotons could serve as signals between neurons, addition well-known electro-chemical signals. For such communication be targeted, photons would need travel waveguides. Here we show, based on detailed...
Genome sequencing of basidiomycetes, a group fungi capable degrading/mineralizing plant material, revealed the presence numerous cytochrome P450 monooxygenases (P450s) in their genomes, with some exceptions. Considering large repertoire P450s found fungi, it is difficult to identify that play an important role fungal metabolism and adaptation diverse ecological niches. In this study, we followed Sir Charles Darwin's theory natural selection such model basidiomycete showing preference for...
The repeating arrangement of tubulin dimers confers great mechanical strength to microtubules, which are used as scaffolds for intracellular macromolecular transport in cells and exploited biohybrid devices. crystalline order a microtubule, with lattice constants short enough allow energy transfer between amino acid chromophores, is similar synthetic structures designed light harvesting. After photoexcitation, can these chromophores excitation along the microtubule like natural or artificial...
This search for magnetic monopoles (MMs) and high electric charge objects (HECOs) with spins 0, 1/2, 1, uses the first time full MoEDAL detector, exposed to 6.46 fb^{-1} proton-proton collisions at 13 TeV. The results are interpreted in terms of Drell-Yan photon-fusion pair production. Mass limits on direct production MMs up 10 Dirac charges HECOs range 10e 400e, were achieved. placed MM HECO currently strongest world. is only LHC experiment capable being directly calibrated highly ionizing...