A5061277872- Laser-Plasma Interactions and Diagnostics
- Radiation Therapy and Dosimetry
- Laser-induced spectroscopy and plasma
- Effects of Radiation Exposure
- High-pressure geophysics and materials
- Nuclear Physics and Applications
- Advanced Optical Sensing Technologies
- Advanced Radiotherapy Techniques
Helmholtz-Zentrum Dresden-Rossendorf
2021-2023
Martin Luther University Halle-Wittenberg
2022
Luther University
2022
Abstract Recent oncological studies identified beneficial properties of radiation applied at ultrahigh dose rates, several orders magnitude higher than the clinical standard order Gy min –1 . Sources capable providing these rates are under investigation. Here we show that a stable, compact laser-driven proton source with energies greater 60 MeV enables radiobiological in vivo studies. We performed pilot irradiation study on human tumours mouse model, showing concerted preparation mice and...
Application experiments with laser plasma-based accelerators (LPA) for protons have to cope the inherent fluctuations of proton source. This creates a demand non-destructive and online spectral characterization pulses, which are application mostly spectrally filtered transported by beamline. Here, we present scintillator-based time-of-flight (ToF) beam monitoring system (BMS) recording single-pulse energy spectra. The setup's capabilities showcased characterizing stability transport LPA two...
Objective.Laser plasma-based accelerators (LPAs) of protons can contribute to research ultra-high dose rate radiobiology as they provide pulse rates unprecedented at medical proton sources. Yet, LPAs pose challenges regarding precise and accurate dosimetry due the high rates, but also sources' lower spectral stability pulsed operation mode. Forin vivomodels, further arise from necessary small field for volumetric distributions. For these novel source parameters intended applications, a...
Abstract Application experiments with laser plasma-based accelerators (LPA) for protons have to cope the inherent fluctuations of proton source. This creates a demand non-destructive and online spectral characterization pulses, which are application mostly spectrally filtered transported by beamline. Here, we present scintillator-based time-of-flight (ToF) beam monitoring system (BMS) recording single-pulse energy spectra. The setup’s capabilities showcased characterizing stability transport...
After the rediscovery of normal tissue sparing effect high dose rate radiation, i.e. so-called FLASH effect, by Favaudon et al. in 2014, research activities on this topic have been revived and are flourishing ever since. Yet, exact biological mechanism as well required boundary conditions radiation qualities to reach said remain mostly unclear. We present a laser-based irradiation platform at Draco PW facility that enables systematic studies into regime using proton peak rates up 10^9 Gy/s....